ENSG00000114023

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000477892 ENSG00000114023 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM162A protein_coding protein_coding 21.23983 21.13348 22.60652 3.047475 0.4176206 0.09716449 19.32884 20.08523 20.27907 2.806554 0.5578456 0.01384981 0.9108542 0.9515 0.8968 -0.0547 0.003807775 0.0001183056 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000114023 E001 3.043777 0.0203159491 5.415796e-01 6.725485e-01 3 122384161 122384175 15 + 0.660 0.564 -0.421
ENSG00000114023 E002 4.777719 0.0385956587 1.866181e-01 3.094940e-01 3 122384176 122384181 6 + 0.871 0.658 -0.856
ENSG00000114023 E003 23.955282 0.0010571841 1.075990e-02 3.059007e-02 3 122384182 122384197 16 + 1.486 1.308 -0.617
ENSG00000114023 E004 77.946319 0.0004608069 7.843466e-05 4.205953e-04 3 122384198 122384229 32 + 1.978 1.821 -0.528
ENSG00000114023 E005 95.292281 0.0014428897 1.274620e-03 4.892770e-03 3 122384230 122384237 8 + 2.050 1.921 -0.433
ENSG00000114023 E006 358.570795 0.0006534902 6.163482e-01 7.344192e-01 3 122384238 122384299 62 + 2.547 2.556 0.028
ENSG00000114023 E007 1.210482 0.0142821025 8.900221e-01 9.337297e-01 3 122384300 122384325 26 + 0.316 0.340 0.153
ENSG00000114023 E008 1.042510 0.0120572208 2.779395e-02 6.760757e-02 3 122387464 122387515 52 + 0.497 0.113 -2.851
ENSG00000114023 E009 7.469518 0.0021522378 4.591551e-07 4.090551e-06 3 122393433 122394724 1292 + 1.173 0.565 -2.379
ENSG00000114023 E010 0.554665 0.0221859079 6.750276e-01 7.804239e-01 3 122400865 122401375 511 + 0.132 0.203 0.738
ENSG00000114023 E011 14.363225 0.0017498655 4.959893e-01 6.327289e-01 3 122401376 122401535 160 + 1.223 1.166 -0.202
ENSG00000114023 E012 1.834991 0.1110446712 9.597803e-01 9.787090e-01 3 122401536 122402759 1224 + 0.444 0.446 0.007
ENSG00000114023 E013 311.779745 0.0008422588 8.349396e-02 1.650219e-01 3 122402760 122402763 4 + 2.469 2.506 0.126
ENSG00000114023 E014 368.334995 0.0004076301 3.413374e-01 4.852460e-01 3 122402764 122402789 26 + 2.554 2.572 0.061
ENSG00000114023 E015 666.726084 0.0002225045 1.899145e-01 3.136523e-01 3 122402790 122402882 93 + 2.812 2.831 0.063
ENSG00000114023 E016 877.329670 0.0001412560 6.797366e-01 7.838359e-01 3 122404258 122404363 106 + 2.940 2.946 0.022
ENSG00000114023 E017 1.913341 0.0077233151 7.474198e-01 8.349339e-01 3 122404364 122404504 141 + 0.497 0.444 -0.265
ENSG00000114023 E018 7.223592 0.0109371342 5.233179e-02 1.133118e-01 3 122404505 122407280 2776 + 1.041 0.802 -0.905
ENSG00000114023 E019 896.792647 0.0001319539 1.417100e-01 2.503781e-01 3 122407281 122407389 109 + 2.942 2.961 0.062
ENSG00000114023 E020 19.212148 0.0053259481 2.287218e-07 2.168593e-06 3 122407390 122409738 2349 + 1.506 1.067 -1.540
ENSG00000114023 E021 846.891959 0.0012934170 5.785418e-01 7.036163e-01 3 122409739 122412334 2596 + 2.931 2.920 -0.036