ENSG00000113966

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335979 ENSG00000113966 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL6 protein_coding protein_coding 6.813106 1.573897 10.1138 0.2741094 0.5471458 2.6762 0.5069879 0.02663078 1.17277695 0.02663078 0.09350212 5.0129778 0.05951250 0.01406667 0.1167667 0.10270000 0.00395663 0.00395663 FALSE TRUE
ENST00000463745 ENSG00000113966 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL6 protein_coding protein_coding 6.813106 1.573897 10.1138 0.2741094 0.5471458 2.6762 1.9717885 0.79793338 3.16761128 0.05607266 0.16560551 1.9756344 0.33383750 0.53350000 0.3143000 -0.21920000 0.04815361 0.00395663 FALSE TRUE
ENST00000496713 ENSG00000113966 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL6 protein_coding processed_transcript 6.813106 1.573897 10.1138 0.2741094 0.5471458 2.6762 1.1492316 0.43456805 1.81022856 0.23503240 0.21278085 2.0336434 0.19053750 0.23686667 0.1782000 -0.05866667 0.98400655 0.00395663 FALSE TRUE
MSTRG.23327.1 ENSG00000113966 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL6 protein_coding   6.813106 1.573897 10.1138 0.2741094 0.5471458 2.6762 0.1047369 0.12794757 0.07532967 0.12794757 0.07532967 -0.6930006 0.02169583 0.06756667 0.0078000 -0.05976667 0.70332950 0.00395663 TRUE TRUE
MSTRG.23327.6 ENSG00000113966 HEK293_OSMI2_2hA HEK293_TMG_2hB ARL6 protein_coding   6.813106 1.573897 10.1138 0.2741094 0.5471458 2.6762 2.3745533 0.10658625 3.45302948 0.10658625 0.30577930 4.8925651 0.27554167 0.10366667 0.3428667 0.23920000 0.16773145 0.00395663 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113966 E001 0.1472490 0.0454192177 1.0000000000   3 97764191 97764520 330 + 0.062 0.000 -7.961
ENSG00000113966 E002 0.1472490 0.0454192177 1.0000000000   3 97764521 97764532 12 + 0.062 0.000 -9.921
ENSG00000113966 E003 3.6232997 0.0135619126 0.7950898643 0.869111138 3 97764533 97764631 99 + 0.594 0.646 0.227
ENSG00000113966 E004 9.4411297 0.0045874641 0.2188671305 0.349046177 3 97764632 97764757 126 + 0.977 0.812 -0.626
ENSG00000113966 E005 7.3189374 0.0022209000 0.2355379435 0.369002681 3 97764758 97764766 9 + 0.882 0.709 -0.686
ENSG00000113966 E006 46.8545427 0.0008764793 0.2117406108 0.340537574 3 97764767 97764977 211 + 1.614 1.540 -0.252
ENSG00000113966 E007 3.2643980 0.0958603615 0.5783481969 0.703466606 3 97765991 97766089 99 + 0.595 0.481 -0.531
ENSG00000113966 E008 0.8084787 0.0889864603 0.9247506323 0.956618213 3 97766632 97766690 59 + 0.208 0.228 0.167
ENSG00000113966 E009 49.6458333 0.0005420018 0.2251538010 0.356608550 3 97768081 97768230 150 + 1.634 1.565 -0.236
ENSG00000113966 E010 24.8586873 0.0007735095 0.3902708335 0.534259505 3 97780159 97780173 15 + 1.345 1.276 -0.241
ENSG00000113966 E011 31.5028753 0.0006587906 0.3653892759 0.509700404 3 97780174 97780220 47 + 1.440 1.374 -0.225
ENSG00000113966 E012 35.2056698 0.0006181470 0.4479009620 0.589252188 3 97780615 97780683 69 + 1.483 1.433 -0.173
ENSG00000113966 E013 34.2144981 0.0006878426 0.2040616831 0.331258611 3 97784955 97785016 62 + 1.440 1.531 0.315
ENSG00000113966 E014 28.2617919 0.0008187381 0.3835774222 0.527785305 3 97785017 97785049 33 + 1.363 1.433 0.245
ENSG00000113966 E015 44.5071025 0.0004942129 0.4536216024 0.594371835 3 97787990 97788119 130 + 1.583 1.540 -0.148
ENSG00000113966 E016 3.9179246 0.0040855252 0.9257201499 0.957244800 3 97791214 97791347 134 + 0.627 0.647 0.085
ENSG00000113966 E017 30.8936606 0.0016026536 0.1041139943 0.196762705 3 97791771 97791826 56 + 1.447 1.320 -0.438
ENSG00000113966 E018 0.5932625 0.1986884445 0.5479714725 0.677899890 3 97791953 97791965 13 + 0.209 0.000 -11.325
ENSG00000113966 E019 0.4439371 0.0216241445 0.7149915441 0.811047261 3 97793372 97793402 31 + 0.165 0.000 -11.588
ENSG00000113966 E020 44.8635078 0.0005536394 0.4662268429 0.605789198 3 97798024 97798203 180 + 1.569 1.618 0.168
ENSG00000113966 E021 163.9789228 0.0008090892 0.9460704998 0.970143970 3 97798204 97800702 2499 + 2.131 2.137 0.020
ENSG00000113966 E022 11.5361319 0.0018171581 0.0002918797 0.001346706 3 97800703 97800765 63 + 0.916 1.291 1.356
ENSG00000113966 E023 24.1404753 0.0216847857 0.0043521741 0.014128420 3 97800766 97801229 464 + 1.239 1.548 1.071
ENSG00000113966 E024 0.4396707 0.0332355290 0.7168354570 0.812383922 3 97812463 97812575 113 + 0.165 0.000 -11.512