ENSG00000113845

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000466984 ENSG00000113845 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMMDC1 protein_coding protein_coding 48.47237 40.59183 65.48167 5.029692 1.08348 0.6897667 2.995127 3.722212 4.892212 0.8676026 1.1955748 0.3934019 0.06427917 0.09870000 0.07416667 -0.02453333 8.516585e-01 2.045211e-07 FALSE FALSE
ENST00000469324 ENSG00000113845 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMMDC1 protein_coding retained_intron 48.47237 40.59183 65.48167 5.029692 1.08348 0.6897667 3.794606 2.407828 5.581757 0.2327434 0.4874301 1.2095900 0.07816250 0.06006667 0.08503333 0.02496667 1.354739e-01 2.045211e-07   FALSE
ENST00000486418 ENSG00000113845 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMMDC1 protein_coding nonsense_mediated_decay 48.47237 40.59183 65.48167 5.029692 1.08348 0.6897667 10.825528 4.227934 17.265291 1.4606642 0.9426306 2.0272770 0.21040417 0.09876667 0.26416667 0.16540000 1.060135e-03 2.045211e-07   FALSE
ENST00000494664 ENSG00000113845 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMMDC1 protein_coding protein_coding 48.47237 40.59183 65.48167 5.029692 1.08348 0.6897667 29.166968 28.762424 35.949112 4.0116991 0.5402209 0.3216706 0.61170417 0.70606667 0.54936667 -0.15670000 2.045211e-07 2.045211e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113845 E001 3.123366 0.0082800379 2.468667e-05 1.499845e-04 3 119498539 119498546 8 + 0.849 0.130 -4.116
ENSG00000113845 E002 4.969898 0.0146692168 4.303881e-03 1.399539e-02 3 119498547 119498551 5 + 0.949 0.536 -1.695
ENSG00000113845 E003 35.751634 0.0098570428 2.052768e-03 7.389989e-03 3 119498552 119498566 15 + 1.673 1.437 -0.806
ENSG00000113845 E004 52.535952 0.0081125974 3.391174e-02 7.957487e-02 3 119498567 119498574 8 + 1.799 1.657 -0.480
ENSG00000113845 E005 125.093030 0.0033379191 5.967456e-05 3.298178e-04 3 119498575 119498580 6 + 2.182 2.015 -0.559
ENSG00000113845 E006 131.706659 0.0032416718 6.738903e-05 3.675125e-04 3 119498581 119498582 2 + 2.202 2.040 -0.542
ENSG00000113845 E007 535.808286 0.0001279479 5.033013e-07 4.449735e-06 3 119498583 119498816 234 + 2.771 2.698 -0.245
ENSG00000113845 E008 493.965107 0.0008858706 5.669852e-03 1.773937e-02 3 119498817 119498927 111 + 2.727 2.670 -0.190
ENSG00000113845 E009 12.147100 0.0182052884 4.505212e-02 1.002913e-01 3 119498928 119498933 6 + 1.224 0.989 -0.850
ENSG00000113845 E010 11.936252 0.0333349873 2.406354e-02 5.994590e-02 3 119498934 119498942 9 + 1.240 0.940 -1.087
ENSG00000113845 E011 34.443344 0.0087609168 1.191491e-03 4.612267e-03 3 119500374 119500694 321 + 1.659 1.411 -0.849
ENSG00000113845 E012 566.002838 0.0001988440 5.386839e-02 1.160210e-01 3 119500695 119500860 166 + 2.773 2.746 -0.091
ENSG00000113845 E013 424.138537 0.0001236752 2.120434e-02 5.402356e-02 3 119503532 119503620 89 + 2.613 2.655 0.139
ENSG00000113845 E014 422.009509 0.0001454586 3.270223e-02 7.720435e-02 3 119503954 119504021 68 + 2.611 2.650 0.130
ENSG00000113845 E015 501.289886 0.0001121658 5.406031e-01 6.717277e-01 3 119513641 119513719 79 + 2.701 2.713 0.041
ENSG00000113845 E016 590.368449 0.0001552082 4.892987e-04 2.119351e-03 3 119517205 119517315 111 + 2.750 2.803 0.176
ENSG00000113845 E017 894.402390 0.0006496319 8.277070e-13 2.059992e-11 3 119523606 119525090 1485 + 2.899 3.006 0.355