ENSG00000113812

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335754 ENSG00000113812 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR8 protein_coding protein_coding 26.36309 20.04554 34.94001 1.796596 1.183093 0.8012917 5.9516859 3.518541 8.436511 0.2725629 0.51620095 1.2592839 0.21695833 0.17603333 0.2428667 0.06683333 1.310048e-01 2.542239e-06 FALSE  
ENST00000486794 ENSG00000113812 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR8 protein_coding protein_coding 26.36309 20.04554 34.94001 1.796596 1.183093 0.8012917 0.7766085 1.412577 0.498272 0.2376579 0.08079454 -1.4848345 0.03178750 0.07110000 0.0142000 -0.05690000 2.542239e-06 2.542239e-06 FALSE  
ENST00000488802 ENSG00000113812 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR8 protein_coding processed_transcript 26.36309 20.04554 34.94001 1.796596 1.183093 0.8012917 2.2773377 1.810890 2.054823 0.7809471 0.18584897 0.1813747 0.09211667 0.08433333 0.0589000 -0.02543333 9.142371e-01 2.542239e-06 FALSE  
ENST00000495993 ENSG00000113812 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR8 protein_coding retained_intron 26.36309 20.04554 34.94001 1.796596 1.183093 0.8012917 3.3840976 2.361355 4.644442 0.5422404 1.18941658 0.9728968 0.13007083 0.12113333 0.1316667 0.01053333 9.367485e-01 2.542239e-06 FALSE  
MSTRG.23114.1 ENSG00000113812 HEK293_OSMI2_2hA HEK293_TMG_2hB ACTR8 protein_coding   26.36309 20.04554 34.94001 1.796596 1.183093 0.8012917 13.8017806 10.805464 18.994372 0.9635189 0.89523215 0.8132358 0.52193750 0.53960000 0.5433000 0.00370000 9.803477e-01 2.542239e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113812 E001 52.962475 0.0005981530 5.200163e-06 3.685992e-05 3 53864902 53865019 118 - 1.815 1.578 -0.804
ENSG00000113812 E002 218.595549 0.0025436904 5.673031e-05 3.152373e-04 3 53867066 53868495 1430 - 2.396 2.256 -0.469
ENSG00000113812 E003 23.559819 0.0008001071 1.209865e-01 2.213432e-01 3 53868496 53868501 6 - 1.434 1.319 -0.399
ENSG00000113812 E004 58.064141 0.0014454975 3.947128e-01 5.385463e-01 3 53868502 53868652 151 - 1.792 1.748 -0.150
ENSG00000113812 E005 36.716381 0.0184206885 1.517911e-01 2.641035e-01 3 53868653 53868673 21 - 1.521 1.643 0.417
ENSG00000113812 E006 204.419436 0.0002252808 3.029007e-05 1.800609e-04 3 53868674 53868862 189 - 2.268 2.368 0.334
ENSG00000113812 E007 237.478400 0.0003588243 5.942537e-04 2.512320e-03 3 53869982 53870145 164 - 2.344 2.423 0.261
ENSG00000113812 E008 6.487095 0.0024724167 6.494916e-01 7.607553e-01 3 53870146 53870297 152 - 0.907 0.849 -0.219
ENSG00000113812 E009 7.247868 0.0026234670 1.300587e-01 2.342422e-01 3 53871158 53871231 74 - 0.984 0.797 -0.714
ENSG00000113812 E010 305.968426 0.0021562331 2.519999e-01 3.883183e-01 3 53871232 53871496 265 - 2.475 2.499 0.081
ENSG00000113812 E011 230.799799 0.0034848411 4.006659e-01 5.443321e-01 3 53872384 53872524 141 - 2.354 2.374 0.067
ENSG00000113812 E012 173.680330 0.0003695061 3.510555e-01 4.952558e-01 3 53873032 53873127 96 - 2.232 2.255 0.075
ENSG00000113812 E013 4.823283 0.0151791333 5.337006e-01 6.658499e-01 3 53873128 53873146 19 - 0.715 0.798 0.336
ENSG00000113812 E014 191.293548 0.0002059797 2.570076e-02 6.331922e-02 3 53874211 53874364 154 - 2.260 2.314 0.180
ENSG00000113812 E015 161.525338 0.0002315921 4.684266e-02 1.035496e-01 3 53875948 53876080 133 - 2.189 2.242 0.176
ENSG00000113812 E016 116.254169 0.0018754096 3.814994e-02 8.763875e-02 3 53876620 53876713 94 - 2.035 2.112 0.257
ENSG00000113812 E017 91.035998 0.0004563835 1.311100e-02 3.616593e-02 3 53877214 53877258 45 - 1.923 2.013 0.302
ENSG00000113812 E018 144.614152 0.0003033325 1.007761e-01 1.916398e-01 3 53877259 53877387 129 - 2.143 2.188 0.153
ENSG00000113812 E019 160.555958 0.0002132619 9.209091e-02 1.783820e-01 3 53877647 53877751 105 - 2.231 2.181 -0.166
ENSG00000113812 E020 179.542636 0.0042104578 1.706357e-02 4.507749e-02 3 53878357 53878467 111 - 2.297 2.200 -0.324
ENSG00000113812 E021 168.544858 0.0003720521 9.106620e-06 6.109575e-05 3 53879939 53880072 134 - 2.281 2.153 -0.431
ENSG00000113812 E022 80.802623 0.0003525065 3.258773e-03 1.102831e-02 3 53880073 53880109 37 - 1.960 1.839 -0.409
ENSG00000113812 E023 2.703260 0.0655912123 1.072663e-01 2.014901e-01 3 53881666 53881978 313 - 0.669 0.348 -1.580
ENSG00000113812 E024 98.709152 0.0050609138 7.581013e-02 1.527938e-01 3 53881979 53882165 187 - 2.037 1.947 -0.304