ENSG00000113810

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357388 ENSG00000113810 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC4 protein_coding protein_coding 68.07437 17.48888 104.2789 3.891027 2.998991 2.57525 24.5335485 0.000000 51.20068083 0.0000000 2.40175269 12.3222290 0.24127500 0.00000000 0.49056667 0.49056667 6.211566e-94 6.211566e-94 FALSE TRUE
ENST00000486711 ENSG00000113810 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC4 protein_coding retained_intron 68.07437 17.48888 104.2789 3.891027 2.998991 2.57525 4.2893713 2.149540 0.76227956 2.1495395 0.76227956 -1.4835286 0.07844583 0.08533333 0.00710000 -0.07823333 8.244952e-01 6.211566e-94   FALSE
MSTRG.24015.1 ENSG00000113810 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC4 protein_coding   68.07437 17.48888 104.2789 3.891027 2.998991 2.57525 1.3385393 3.323834 0.05272096 0.3352017 0.05272096 -5.7320906 0.07164583 0.20640000 0.00050000 -0.20590000 9.896904e-10 6.211566e-94 FALSE TRUE
MSTRG.24015.15 ENSG00000113810 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC4 protein_coding   68.07437 17.48888 104.2789 3.891027 2.998991 2.57525 3.4857638 3.539538 2.31942831 2.1959355 0.82054421 -0.6076555 0.05592083 0.16983333 0.02256667 -0.14726667 6.465687e-01 6.211566e-94 FALSE TRUE
MSTRG.24015.16 ENSG00000113810 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC4 protein_coding   68.07437 17.48888 104.2789 3.891027 2.998991 2.57525 8.1963047 5.036738 6.26352752 1.2905178 1.74949395 0.3139256 0.23212500 0.34226667 0.06003333 -0.28223333 4.447030e-02 6.211566e-94 FALSE TRUE
MSTRG.24015.18 ENSG00000113810 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC4 protein_coding   68.07437 17.48888 104.2789 3.891027 2.998991 2.57525 0.6492638 1.133594 0.75784949 0.5800198 0.37941662 -0.5746798 0.01791667 0.05930000 0.00740000 -0.05190000 6.676713e-01 6.211566e-94 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113810 E001 0.0000000       3 160399274 160399277 4 +      
ENSG00000113810 E002 2.0723229 0.0193307785 1.074265e-01 2.017490e-01 3 160399278 160399352 75 + 0.411 0.000 -11.836
ENSG00000113810 E003 3.7677706 0.0108442923 4.736734e-01 6.126120e-01 3 160399638 160399638 1 + 0.555 0.459 -0.463
ENSG00000113810 E004 3.9192860 0.0156786115 4.384911e-01 5.803751e-01 3 160399639 160399642 4 + 0.569 0.459 -0.525
ENSG00000113810 E005 3.7720370 0.0543524211 5.186718e-01 6.528958e-01 3 160399643 160399644 2 + 0.556 0.460 -0.463
ENSG00000113810 E006 4.6535686 0.0172137428 2.820679e-01 4.220267e-01 3 160399645 160399649 5 + 0.630 0.459 -0.798
ENSG00000113810 E007 4.8050840 0.0214271077 2.623652e-01 4.001538e-01 3 160399650 160399650 1 + 0.642 0.459 -0.847
ENSG00000113810 E008 5.2898192 0.0808828475 5.398368e-01 6.710616e-01 3 160399651 160399651 1 + 0.664 0.583 -0.353
ENSG00000113810 E009 23.0925666 0.0008906970 4.401333e-05 2.513700e-04 3 160399652 160399665 14 + 1.253 0.756 -1.847
ENSG00000113810 E010 28.8448350 0.0006707943 6.258517e-07 5.431029e-06 3 160399666 160399666 1 + 1.348 0.756 -2.180
ENSG00000113810 E011 55.3781788 0.0005364967 4.864333e-09 6.361544e-08 3 160399667 160399667 1 + 1.615 1.151 -1.612
ENSG00000113810 E012 69.6812257 0.0029617167 8.580933e-09 1.071115e-07 3 160399668 160399668 1 + 1.710 1.297 -1.418
ENSG00000113810 E013 96.4303775 0.0069462472 2.418259e-09 3.338180e-08 3 160399669 160399683 15 + 1.848 1.437 -1.399
ENSG00000113810 E014 99.3123251 0.0066900900 6.327796e-10 9.746987e-09 3 160399684 160399697 14 + 1.861 1.438 -1.441
ENSG00000113810 E015 126.5305535 0.0054981889 5.257950e-15 1.802575e-13 3 160399698 160399749 52 + 1.970 1.452 -1.758
ENSG00000113810 E016 77.0920771 0.0003339379 7.152570e-02 1.458750e-01 3 160399750 160400481 732 + 1.722 1.690 -0.110
ENSG00000113810 E017 29.6750550 0.0006932432 8.494403e-02 1.673206e-01 3 160400482 160400599 118 + 1.326 1.230 -0.336
ENSG00000113810 E018 33.4476106 0.0005888591 3.369044e-04 1.527986e-03 3 160400600 160400627 28 + 1.394 1.089 -1.076
ENSG00000113810 E019 52.0473598 0.0007286655 5.084921e-07 4.492902e-06 3 160400628 160400821 194 + 1.585 1.205 -1.315
ENSG00000113810 E020 182.7361821 0.0135759560 3.221687e-12 7.276335e-11 3 160400822 160400965 144 + 2.127 1.639 -1.644
ENSG00000113810 E021 96.3533124 0.0602238607 7.953075e-05 4.256657e-04 3 160401915 160401923 9 + 1.851 1.378 -1.612
ENSG00000113810 E022 156.6060004 0.0061633487 4.651522e-13 1.204013e-11 3 160401924 160401989 66 + 2.057 1.638 -1.413
ENSG00000113810 E023 214.2239307 0.0044217960 5.714666e-15 1.949304e-13 3 160401990 160402093 104 + 2.189 1.821 -1.235
ENSG00000113810 E024 241.0604607 0.0001901252 1.402404e-21 1.068709e-19 3 160402676 160402808 133 + 2.236 1.918 -1.066
ENSG00000113810 E025 162.4794889 0.0037425915 5.433716e-08 5.810573e-07 3 160402809 160402867 59 + 2.059 1.827 -0.781
ENSG00000113810 E026 0.1515154 0.0427713443 7.926299e-01   3 160403991 160404071 81 + 0.046 0.000 -7.988
ENSG00000113810 E027 163.5225972 0.0024648083 2.084599e-08 2.422086e-07 3 160404328 160404377 50 + 2.061 1.839 -0.746
ENSG00000113810 E028 297.5102539 0.0009824560 3.589800e-17 1.629707e-15 3 160404378 160404498 121 + 2.321 2.071 -0.835
ENSG00000113810 E029 164.5849365 0.0003399728 4.258500e-11 7.995640e-10 3 160404499 160404504 6 + 2.065 1.825 -0.806
ENSG00000113810 E030 3.9892158 0.0067887699 8.745213e-01 9.233173e-01 3 160411758 160411919 162 + 0.555 0.582 0.122
ENSG00000113810 E031 279.8490010 0.0069134776 9.281644e-09 1.151526e-07 3 160411920 160411977 58 + 2.294 2.060 -0.783
ENSG00000113810 E032 266.7550654 0.0129032059 1.359440e-07 1.346413e-06 3 160411978 160412021 44 + 2.276 2.006 -0.903
ENSG00000113810 E033 277.2303419 0.0001917321 2.681048e-16 1.095829e-14 3 160412022 160412084 63 + 2.289 2.067 -0.742
ENSG00000113810 E034 192.1281246 0.0002062422 1.386212e-11 2.821679e-10 3 160412326 160412334 9 + 2.130 1.913 -0.729
ENSG00000113810 E035 287.2283212 0.0003405631 7.422892e-10 1.128426e-08 3 160412335 160412453 119 + 2.297 2.161 -0.454
ENSG00000113810 E036 2.0777472 0.0081419881 5.150441e-01 6.497583e-01 3 160412454 160412529 76 + 0.392 0.288 -0.642
ENSG00000113810 E037 9.4920856 0.0062010324 7.591123e-01 8.435350e-01 3 160412530 160412849 320 + 0.857 0.880 0.086
ENSG00000113810 E038 0.1472490 0.0438385246 7.936390e-01   3 160412850 160412852 3 + 0.046 0.000 -7.987
ENSG00000113810 E039 256.4887735 0.0047368744 2.152388e-02 5.469077e-02 3 160413473 160413613 141 + 2.238 2.205 -0.112
ENSG00000113810 E040 10.0797594 0.0017045587 3.740028e-01 5.184177e-01 3 160413614 160413754 141 + 0.890 0.822 -0.262
ENSG00000113810 E041 21.5211064 0.0063950803 7.406768e-02 1.500353e-01 3 160414023 160414366 344 + 1.201 1.055 -0.524
ENSG00000113810 E042 188.8798844 0.0031613510 5.152888e-02 1.118699e-01 3 160414367 160414437 71 + 2.104 2.088 -0.055
ENSG00000113810 E043 202.2753967 0.0089767277 3.147468e-01 4.574862e-01 3 160414438 160414517 80 + 2.129 2.145 0.052
ENSG00000113810 E044 311.4728337 0.0095462168 4.349795e-02 9.746601e-02 3 160416251 160416415 165 + 2.321 2.288 -0.112
ENSG00000113810 E045 7.4331056 0.0022045870 3.691653e-02 8.529974e-02 3 160416416 160416627 212 + 0.807 0.459 -1.525
ENSG00000113810 E046 6.8877886 0.0086341665 6.035478e-02 1.272133e-01 3 160417624 160417722 99 + 0.775 0.459 -1.400
ENSG00000113810 E047 479.6636794 0.0018716334 1.628600e-07 1.588659e-06 3 160417723 160417956 234 + 2.514 2.422 -0.306
ENSG00000113810 E048 417.3482851 0.0002725618 1.570355e-05 9.975918e-05 3 160419358 160419543 186 + 2.448 2.408 -0.131
ENSG00000113810 E049 3.8159305 0.0043758848 4.660938e-01 6.056594e-01 3 160420582 160420739 158 + 0.555 0.459 -0.463
ENSG00000113810 E050 418.5922588 0.0001861837 7.169883e-06 4.924278e-05 3 160420740 160420901 162 + 2.449 2.406 -0.141
ENSG00000113810 E051 547.9601779 0.0007228684 1.310355e-05 8.467251e-05 3 160423425 160423650 226 + 2.564 2.531 -0.109
ENSG00000113810 E052 344.7844948 0.0001774259 5.707835e-04 2.424512e-03 3 160423761 160423840 80 + 2.363 2.341 -0.073
ENSG00000113810 E053 441.2608396 0.0001372568 1.268531e-01 2.297662e-01 3 160424867 160425019 153 + 2.461 2.502 0.138
ENSG00000113810 E054 385.8379483 0.0001447752 4.492732e-01 5.904670e-01 3 160426074 160426200 127 + 2.394 2.493 0.330
ENSG00000113810 E055 232.4396838 0.0004130826 7.794649e-01 8.581914e-01 3 160428753 160428795 43 + 2.180 2.250 0.233
ENSG00000113810 E056 408.4582063 0.0010255313 5.588205e-01 6.870085e-01 3 160428796 160428942 147 + 2.425 2.489 0.213
ENSG00000113810 E057 356.6644482 0.0010184084 1.220092e-01 2.227968e-01 3 160430599 160430743 145 + 2.356 2.484 0.426
ENSG00000113810 E058 6.1080617 0.0263449189 3.122305e-01 4.547603e-01 3 160430744 160430928 185 + 0.722 0.582 -0.603
ENSG00000113810 E059 2.2683972 0.3641432359 6.577769e-01 7.670764e-01 3 160430929 160431031 103 + 0.409 0.293 -0.702
ENSG00000113810 E060 365.4391824 0.0021115101 6.617411e-06 4.582887e-05 3 160431032 160431205 174 + 2.346 2.580 0.779
ENSG00000113810 E061 523.0426606 0.0006077935 2.258676e-21 1.690285e-19 3 160431643 160431825 183 + 2.488 2.784 0.985
ENSG00000113810 E062 594.2561769 0.0015718810 1.317572e-33 2.905820e-31 3 160432283 160432515 233 + 2.523 2.910 1.290
ENSG00000113810 E063 453.0822445 0.0019474445 2.985440e-38 9.211443e-36 3 160433026 160433209 184 + 2.389 2.836 1.492
ENSG00000113810 E064 1278.2387756 0.0212451587 9.454958e-11 1.675127e-09 3 160433657 160435011 1355 + 2.825 3.325 1.665