ENSG00000113761

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358149 ENSG00000113761 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF346 protein_coding protein_coding 28.40155 32.63633 25.42737 1.66896 0.2188259 -0.3599712 6.274891 8.3236939 4.673884 0.7197681 0.4206506 -0.8312508 0.21875417 0.25590000 0.18410000 -0.07180000 2.092711e-01 1.498365e-05 FALSE  
ENST00000503425 ENSG00000113761 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF346 protein_coding protein_coding 28.40155 32.63633 25.42737 1.66896 0.2188259 -0.3599712 5.805490 7.6137379 4.282131 0.8030836 0.7445936 -0.8288042 0.20301250 0.23516667 0.16843333 -0.06673333 4.841548e-01 1.498365e-05 FALSE  
ENST00000504600 ENSG00000113761 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF346 protein_coding retained_intron 28.40155 32.63633 25.42737 1.66896 0.2188259 -0.3599712 1.002135 0.0000000 1.291244 0.0000000 0.7279603 7.0237478 0.03594167 0.00000000 0.05080000 0.05080000 1.498365e-05 1.498365e-05 FALSE  
ENST00000511834 ENSG00000113761 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF346 protein_coding protein_coding 28.40155 32.63633 25.42737 1.66896 0.2188259 -0.3599712 2.770268 3.8992213 2.021434 0.2846764 0.4691869 -0.9443826 0.09670000 0.12016667 0.07946667 -0.04070000 4.039502e-01 1.498365e-05 FALSE  
ENST00000513587 ENSG00000113761 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF346 protein_coding nonsense_mediated_decay 28.40155 32.63633 25.42737 1.66896 0.2188259 -0.3599712 4.604959 5.7350702 3.165759 0.6726455 0.5736919 -0.8552230 0.16009167 0.17526667 0.12410000 -0.05116667 3.700407e-01 1.498365e-05 TRUE  
MSTRG.27372.16 ENSG00000113761 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF346 protein_coding   28.40155 32.63633 25.42737 1.66896 0.2188259 -0.3599712 2.762008 2.7433282 2.542211 0.6109161 0.8111136 -0.1094290 0.09730833 0.08326667 0.10026667 0.01700000 9.314009e-01 1.498365e-05 FALSE  
MSTRG.27372.2 ENSG00000113761 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF346 protein_coding   28.40155 32.63633 25.42737 1.66896 0.2188259 -0.3599712 1.167914 0.3460087 2.575352 0.3460087 0.2459530 2.8603760 0.04327917 0.00980000 0.10140000 0.09160000 4.123072e-02 1.498365e-05 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113761 E001 1.986406 0.0161049681 4.930542e-01 6.301181e-01 5 177022108 177022289 182 + 0.543 0.444 -0.484
ENSG00000113761 E002 1.297265 0.0102685136 4.519015e-01 5.928151e-01 5 177022696 177022703 8 + 0.425 0.306 -0.701
ENSG00000113761 E003 8.430814 0.0028477778 6.822308e-04 2.834231e-03 5 177022704 177022715 12 + 1.154 0.803 -1.308
ENSG00000113761 E004 29.533063 0.0021332930 6.739270e-04 2.803361e-03 5 177022716 177022731 16 + 1.584 1.380 -0.699
ENSG00000113761 E005 35.976254 0.0048608365 1.255844e-02 3.487072e-02 5 177022732 177022734 3 + 1.632 1.487 -0.497
ENSG00000113761 E006 139.649559 0.0026396724 2.735594e-02 6.671860e-02 5 177022735 177022903 169 + 2.165 2.101 -0.215
ENSG00000113761 E007 100.085313 0.0064383840 8.863122e-01 9.312974e-01 5 177022904 177022913 10 + 1.971 1.983 0.040
ENSG00000113761 E008 2.030412 0.0071365933 8.046706e-01 8.757106e-01 5 177023127 177023132 6 + 0.425 0.483 0.300
ENSG00000113761 E009 2.205774 0.0072438620 6.518075e-01 7.626124e-01 5 177023133 177023159 27 + 0.425 0.518 0.470
ENSG00000113761 E010 9.581593 0.0017575603 2.574491e-01 3.945681e-01 5 177023160 177023234 75 + 1.071 0.974 -0.357
ENSG00000113761 E011 192.588694 0.0007029075 6.584604e-03 2.014622e-02 5 177041126 177041229 104 + 2.298 2.245 -0.177
ENSG00000113761 E012 184.721262 0.0006888320 1.394426e-02 3.809500e-02 5 177041778 177041870 93 + 2.276 2.230 -0.156
ENSG00000113761 E013 3.555177 0.0565854691 3.991110e-02 9.087046e-02 5 177041871 177042249 379 + 0.832 0.485 -1.495
ENSG00000113761 E014 1.887419 0.0076745678 1.354216e-01 2.416998e-01 5 177044327 177044388 62 + 0.591 0.357 -1.187
ENSG00000113761 E015 48.947702 0.0127567314 4.446139e-01 5.861694e-01 5 177044389 177044391 3 + 1.695 1.659 -0.121
ENSG00000113761 E016 195.561716 0.0025600937 1.407812e-01 2.490855e-01 5 177044392 177044533 142 + 2.289 2.260 -0.096
ENSG00000113761 E017 27.132865 0.0072949405 2.566953e-01 3.936613e-01 5 177050703 177050750 48 + 1.345 1.457 0.388
ENSG00000113761 E018 241.303152 0.0002494362 5.263387e-01 6.595841e-01 5 177050751 177050936 186 + 2.357 2.366 0.029
ENSG00000113761 E019 216.320838 0.0003507554 1.322743e-01 2.372762e-01 5 177062058 177062151 94 + 2.275 2.338 0.210
ENSG00000113761 E020 245.994886 0.0007904558 2.481449e-02 6.149399e-02 5 177064512 177064601 90 + 2.315 2.398 0.275
ENSG00000113761 E021 528.390721 0.0009771085 3.687189e-09 4.918583e-08 5 177064602 177065100 499 + 2.602 2.743 0.470
ENSG00000113761 E022 810.080396 0.0034755179 2.082286e-03 7.479364e-03 5 177065101 177067985 2885 + 2.817 2.917 0.334
ENSG00000113761 E023 31.975573 0.0006271209 1.407056e-18 7.605209e-17 5 177079382 177079648 267 + 1.765 1.252 -1.765
ENSG00000113761 E024 101.701728 0.0004248288 1.768611e-31 3.284883e-29 5 177079649 177081189 1541 + 2.207 1.823 -1.289
ENSG00000113761 E025 1.434120 0.0114487920 1.372611e-02 3.760043e-02 5 177086156 177086245 90 + 0.591 0.179 -2.506