ENSG00000113739

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265087 ENSG00000113739 HEK293_OSMI2_2hA HEK293_TMG_2hB STC2 protein_coding protein_coding 32.83549 23.40111 23.43806 0.6869984 0.2978793 0.00227499 24.978788 21.5097190 16.959338 0.4236566 0.1910084 -0.3427289 0.77870417 0.92076667 0.72356667 -0.1972000 0.00696379 0.00696379 FALSE TRUE
ENST00000519511 ENSG00000113739 HEK293_OSMI2_2hA HEK293_TMG_2hB STC2 protein_coding retained_intron 32.83549 23.40111 23.43806 0.6869984 0.2978793 0.00227499 5.556312 0.6794908 4.656144 0.6794908 0.4073112 2.7586275 0.15152083 0.02796667 0.19883333 0.1708667 0.06132779 0.00696379 FALSE FALSE
ENST00000520648 ENSG00000113739 HEK293_OSMI2_2hA HEK293_TMG_2hB STC2 protein_coding protein_coding 32.83549 23.40111 23.43806 0.6869984 0.2978793 0.00227499 1.839837 0.8400494 1.621815 0.1558910 0.5126279 0.9408585 0.05446667 0.03556667 0.06886667 0.0333000 0.54569562 0.00696379 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113739 E001 1857.8429091 0.003415567 0.0161098307 0.0429814205 5 173314723 173318177 3455 - 3.223 3.278 0.182
ENSG00000113739 E002 154.7191376 0.002501893 0.6416469532 0.7546301617 5 173318178 173318249 72 - 2.155 2.201 0.154
ENSG00000113739 E003 12.5297877 0.001395262 0.0001227846 0.0006265974 5 173322969 173323218 250 - 1.295 0.964 -1.189
ENSG00000113739 E004 149.5500721 0.000299365 0.4190730887 0.5623276138 5 173323219 173323309 91 - 2.163 2.167 0.013
ENSG00000113739 E005 169.4870450 0.001905308 0.4231004153 0.5662162506 5 173323310 173323430 121 - 2.217 2.217 0.000
ENSG00000113739 E006 1.7263515 0.008710971 0.7902626172 0.8658378127 5 173324005 173324286 282 - 0.458 0.431 -0.142
ENSG00000113739 E007 1.1823829 0.035072564 0.4283309817 0.5711330984 5 173325834 173325867 34 - 0.397 0.268 -0.814
ENSG00000113739 E008 200.7885559 0.005030487 0.1685519682 0.2862773753 5 173325868 173326010 143 - 2.308 2.280 -0.095
ENSG00000113739 E009 0.6966155 0.016778814 0.4963114543 0.6330053527 5 173326589 173326797 209 - 0.138 0.267 1.183
ENSG00000113739 E010 266.4059222 0.002707796 0.0007381036 0.0030361195 5 173328043 173328447 405 - 2.460 2.382 -0.260