ENSG00000113716

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000502717 ENSG00000113716 HEK293_OSMI2_2hA HEK293_TMG_2hB HMGXB3 protein_coding protein_coding 38.42002 55.17669 28.23209 2.521774 0.2741333 -0.9664733 17.907488 21.879520 16.597251 2.97719028 0.28412113 -0.3984270 0.49380000 0.39436667 0.5879000 0.19353333 5.653719e-03 8.797195e-10 FALSE TRUE
ENST00000513318 ENSG00000113716 HEK293_OSMI2_2hA HEK293_TMG_2hB HMGXB3 protein_coding retained_intron 38.42002 55.17669 28.23209 2.521774 0.2741333 -0.9664733 2.447670 1.951542 2.535592 0.05429733 0.08874243 0.3760133 0.06958333 0.03543333 0.0899000 0.05446667 8.797195e-10 8.797195e-10   FALSE
ENST00000613459 ENSG00000113716 HEK293_OSMI2_2hA HEK293_TMG_2hB HMGXB3 protein_coding protein_coding 38.42002 55.17669 28.23209 2.521774 0.2741333 -0.9664733 3.065572 2.740688 3.219329 0.58473826 0.22401066 0.2314418 0.08624167 0.04906667 0.1139000 0.06483333 3.522224e-03 8.797195e-10 FALSE TRUE
MSTRG.27159.5 ENSG00000113716 HEK293_OSMI2_2hA HEK293_TMG_2hB HMGXB3 protein_coding   38.42002 55.17669 28.23209 2.521774 0.2741333 -0.9664733 13.864387 27.253907 4.835672 2.35126252 0.22231039 -2.4922237 0.32075000 0.49726667 0.1714667 -0.32580000 7.905888e-07 8.797195e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113716 E001 0.000000       5 150000046 150000055 10 +      
ENSG00000113716 E002 0.000000       5 150000321 150000453 133 +      
ENSG00000113716 E003 25.436519 0.0037455125 1.110336e-04 5.725361e-04 5 150000454 150000738 285 + 1.542 1.287 -0.883
ENSG00000113716 E004 123.975075 0.0119804282 5.358909e-03 1.690696e-02 5 150000739 150000931 193 + 2.148 2.014 -0.448
ENSG00000113716 E005 123.825782 0.0086710201 2.132193e-04 1.020637e-03 5 150000932 150001179 248 + 2.168 2.000 -0.562
ENSG00000113716 E006 131.101834 0.0051915374 1.061947e-04 5.504918e-04 5 150004851 150004989 139 + 2.179 2.032 -0.493
ENSG00000113716 E007 93.009134 0.0077832663 6.325215e-02 1.321270e-01 5 150006473 150006518 46 + 1.985 1.913 -0.243
ENSG00000113716 E008 170.525423 0.0025379923 2.718768e-03 9.429062e-03 5 150006519 150006647 129 + 2.250 2.171 -0.263
ENSG00000113716 E009 425.018166 0.0041322860 1.160413e-06 9.505630e-06 5 150010111 150010608 498 + 2.681 2.547 -0.444
ENSG00000113716 E010 180.902588 0.0033596435 6.646150e-06 4.601108e-05 5 150012255 150012353 99 + 2.315 2.174 -0.470
ENSG00000113716 E011 217.593388 0.0038536845 2.384170e-05 1.453168e-04 5 150018566 150018697 132 + 2.388 2.259 -0.430
ENSG00000113716 E012 4.533079 0.0036288000 1.065116e-02 3.033555e-02 5 150021782 150021972 191 + 0.910 0.586 -1.321
ENSG00000113716 E013 249.612498 0.0034281543 3.337470e-05 1.961938e-04 5 150024262 150024408 147 + 2.439 2.323 -0.388
ENSG00000113716 E014 235.085546 0.0033743796 1.680467e-04 8.268004e-04 5 150024409 150024504 96 + 2.404 2.300 -0.346
ENSG00000113716 E015 325.928589 0.0012704592 2.340566e-08 2.692143e-07 5 150024505 150024680 176 + 2.552 2.439 -0.376
ENSG00000113716 E016 270.983570 0.0013805808 1.296805e-03 4.965757e-03 5 150026706 150026881 176 + 2.435 2.376 -0.197
ENSG00000113716 E017 141.914175 0.0014567614 2.185826e-02 5.538366e-02 5 150027020 150027062 43 + 2.149 2.098 -0.170
ENSG00000113716 E018 166.142441 0.0014940794 5.291932e-02 1.143346e-01 5 150027063 150027117 55 + 2.207 2.173 -0.114
ENSG00000113716 E019 35.764515 0.0005689069 3.721016e-06 2.729345e-05 5 150030317 150030740 424 + 1.683 1.441 -0.827
ENSG00000113716 E020 244.732311 0.0002097308 9.686601e-03 2.799111e-02 5 150030741 150030839 99 + 2.373 2.341 -0.107
ENSG00000113716 E021 328.507838 0.0004827869 2.069933e-02 5.295504e-02 5 150032454 150032603 150 + 2.494 2.472 -0.071
ENSG00000113716 E022 461.200066 0.0016549529 7.668227e-01 8.492127e-01 5 150036636 150036937 302 + 2.608 2.634 0.088
ENSG00000113716 E023 280.006503 0.0013821920 6.620819e-01 7.704392e-01 5 150037400 150037527 128 + 2.380 2.425 0.151
ENSG00000113716 E024 331.136288 0.0001718693 6.310982e-01 7.461939e-01 5 150040748 150040879 132 + 2.469 2.490 0.070
ENSG00000113716 E025 435.154076 0.0001323383 9.279285e-01 9.586388e-01 5 150041785 150041969 185 + 2.579 2.612 0.109
ENSG00000113716 E026 509.897700 0.0001653726 4.575403e-02 1.015864e-01 5 150045466 150045685 220 + 2.624 2.690 0.221
ENSG00000113716 E027 4.338586 0.0038082587 1.778088e-01 2.983776e-01 5 150047485 150047623 139 + 0.803 0.636 -0.683
ENSG00000113716 E028 344.446549 0.0013472901 9.566431e-06 6.387522e-05 5 150047624 150047757 134 + 2.390 2.544 0.513
ENSG00000113716 E029 316.848827 0.0001868394 1.977772e-04 9.543144e-04 5 150048569 150048685 117 + 2.382 2.497 0.383
ENSG00000113716 E030 434.770675 0.0003535784 1.032272e-04 5.369897e-04 5 150050252 150050461 210 + 2.522 2.632 0.369
ENSG00000113716 E031 2153.424904 0.0056905927 5.100724e-10 7.970281e-09 5 150051725 150053142 1418 + 3.131 3.355 0.746