ENSG00000113649

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296702 ENSG00000113649 HEK293_OSMI2_2hA HEK293_TMG_2hB TCERG1 protein_coding protein_coding 45.28259 27.10032 63.96368 0.4928895 3.106769 1.238636 4.1487427 2.95101374 6.380667 0.82471746 0.4071042 1.109875 0.09268750 0.108133333 0.10040000 -0.007733333 1.000000e+00 3.108175e-46 FALSE TRUE
ENST00000394421 ENSG00000113649 HEK293_OSMI2_2hA HEK293_TMG_2hB TCERG1 protein_coding protein_coding 45.28259 27.10032 63.96368 0.4928895 3.106769 1.238636 20.2261428 8.84262349 30.298327 2.62001898 1.8613484 1.775537 0.41160000 0.324266667 0.47416667 0.149900000 4.669323e-01 3.108175e-46 FALSE TRUE
ENST00000505285 ENSG00000113649 HEK293_OSMI2_2hA HEK293_TMG_2hB TCERG1 protein_coding retained_intron 45.28259 27.10032 63.96368 0.4928895 3.106769 1.238636 4.1496222 0.07512432 7.836940 0.07512432 2.0494744 6.526415 0.06149167 0.002833333 0.12010000 0.117266667 5.399323e-04 3.108175e-46 FALSE FALSE
ENST00000515203 ENSG00000113649 HEK293_OSMI2_2hA HEK293_TMG_2hB TCERG1 protein_coding processed_transcript 45.28259 27.10032 63.96368 0.4928895 3.106769 1.238636 2.3751609 0.00000000 5.252381 0.00000000 0.7506210 9.039572 0.03716667 0.000000000 0.08156667 0.081566667 8.886625e-24 3.108175e-46 FALSE FALSE
MSTRG.27114.12 ENSG00000113649 HEK293_OSMI2_2hA HEK293_TMG_2hB TCERG1 protein_coding   45.28259 27.10032 63.96368 0.4928895 3.106769 1.238636 0.2959419 1.43809219 0.000000 1.43809219 0.0000000 -7.178010 0.01390000 0.053666667 0.00000000 -0.053666667 7.186962e-01 3.108175e-46 FALSE TRUE
MSTRG.27114.16 ENSG00000113649 HEK293_OSMI2_2hA HEK293_TMG_2hB TCERG1 protein_coding   45.28259 27.10032 63.96368 0.4928895 3.106769 1.238636 2.7060476 7.31736436 0.000000 0.81380583 0.0000000 -9.517151 0.10308333 0.270366667 0.00000000 -0.270366667 3.108175e-46 3.108175e-46 FALSE TRUE
MSTRG.27114.5 ENSG00000113649 HEK293_OSMI2_2hA HEK293_TMG_2hB TCERG1 protein_coding   45.28259 27.10032 63.96368 0.4928895 3.106769 1.238636 0.9878101 2.21518527 0.000000 1.34834589 0.0000000 -7.797782 0.03405000 0.082300000 0.00000000 -0.082300000 1.006354e-01 3.108175e-46 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113649 E001 2.0057266 0.0103265708 2.288068e-02 5.749441e-02 5 146447217 146447310 94 + 0.569 0.167 -2.525
ENSG00000113649 E002 1.3403442 0.0298029401 1.254832e-02 3.484824e-02 5 146447311 146447311 1 + 0.481 0.000 -12.262
ENSG00000113649 E003 3.8910716 0.0045971298 7.069780e-03 2.140731e-02 5 146447312 146447325 14 + 0.791 0.382 -1.881
ENSG00000113649 E004 6.6233886 0.0096413137 4.523785e-02 1.006264e-01 5 146447326 146447330 5 + 0.949 0.717 -0.905
ENSG00000113649 E005 8.9744011 0.0019033220 6.500709e-03 1.992493e-02 5 146447331 146447332 2 + 1.073 0.790 -1.067
ENSG00000113649 E006 32.7294006 0.0006922925 3.318346e-07 3.042104e-06 5 146447333 146447345 13 + 1.602 1.296 -1.054
ENSG00000113649 E007 91.6030800 0.0054194445 2.854362e-04 1.320610e-03 5 146447346 146447408 63 + 1.998 1.852 -0.490
ENSG00000113649 E008 232.3141500 0.0060900687 1.090964e-05 7.185365e-05 5 146455056 146455281 226 + 2.399 2.250 -0.497
ENSG00000113649 E009 206.4167146 0.0020103612 9.279706e-15 3.066479e-13 5 146457183 146457335 153 + 2.367 2.144 -0.743
ENSG00000113649 E010 150.1365112 0.0139532908 1.983594e-04 9.568312e-04 5 146458884 146458991 108 + 2.223 2.031 -0.644
ENSG00000113649 E011 86.0007650 0.0084477899 2.599819e-04 1.216749e-03 5 146458992 146459051 60 + 1.977 1.801 -0.594
ENSG00000113649 E012 38.9858748 0.0333072991 8.196414e-04 3.329587e-03 5 146459052 146459063 12 + 1.673 1.357 -1.085
ENSG00000113649 E013 39.8096478 0.0122318282 3.749595e-03 1.243805e-02 5 146459064 146459075 12 + 1.650 1.463 -0.641
ENSG00000113649 E014 39.6322244 0.0046844829 2.177564e-04 1.039886e-03 5 146459076 146459081 6 + 1.655 1.445 -0.717
ENSG00000113649 E015 73.0753917 0.0083456694 1.591077e-03 5.930523e-03 5 146459082 146459135 54 + 1.901 1.748 -0.515
ENSG00000113649 E016 71.4043565 0.0034387280 2.669585e-03 9.280916e-03 5 146459136 146459153 18 + 1.878 1.767 -0.375
ENSG00000113649 E017 106.0161131 0.0011196650 1.314232e-05 8.490276e-05 5 146459154 146459214 61 + 2.054 1.928 -0.424
ENSG00000113649 E018 184.1284133 0.0009544849 1.194236e-09 1.743830e-08 5 146459215 146459337 123 + 2.297 2.153 -0.483
ENSG00000113649 E019 6.0729489 0.0088498832 2.450767e-02 6.086819e-02 5 146462018 146462056 39 + 0.915 0.633 -1.133
ENSG00000113649 E020 5.1045383 0.0112239295 6.524295e-04 2.724345e-03 5 146462057 146462096 40 + 0.903 0.382 -2.311
ENSG00000113649 E021 307.5121159 0.0025300539 1.753774e-07 1.699822e-06 5 146463551 146463793 243 + 2.512 2.392 -0.400
ENSG00000113649 E022 23.7419260 0.0068969172 2.824147e-01 4.224279e-01 5 146468341 146468403 63 + 1.388 1.346 -0.146
ENSG00000113649 E023 247.0408219 0.0001911693 1.517233e-03 5.691898e-03 5 146469544 146469744 201 + 2.386 2.358 -0.095
ENSG00000113649 E024 0.0000000       5 146469745 146469809 65 +      
ENSG00000113649 E025 86.9749195 0.0003613912 7.150377e-01 8.110802e-01 5 146470636 146470640 5 + 1.903 1.965 0.208
ENSG00000113649 E026 181.8629733 0.0006971924 5.391821e-02 1.161177e-01 5 146470641 146470748 108 + 2.249 2.239 -0.032
ENSG00000113649 E027 180.1865732 0.0012554635 2.943405e-02 7.084299e-02 5 146471488 146471576 89 + 2.249 2.227 -0.073
ENSG00000113649 E028 0.8888167 0.0641294205 4.957209e-01 6.324736e-01 5 146478418 146478492 75 + 0.224 0.379 1.043
ENSG00000113649 E029 145.1191650 0.0008099698 3.965671e-02 9.039019e-02 5 146478493 146478524 32 + 2.155 2.135 -0.067
ENSG00000113649 E030 265.2962391 0.0002395226 3.510925e-04 1.584529e-03 5 146478525 146478653 129 + 2.421 2.386 -0.120
ENSG00000113649 E031 220.2179426 0.0001854637 7.561437e-05 4.071776e-04 5 146479855 146479911 57 + 2.346 2.293 -0.177
ENSG00000113649 E032 227.4499417 0.0023352863 1.928901e-01 3.174004e-01 5 146480028 146480094 67 + 2.341 2.345 0.014
ENSG00000113649 E033 16.6616387 0.0010653968 1.412912e-13 3.929554e-12 5 146480095 146480518 424 + 1.392 0.582 -3.070
ENSG00000113649 E034 15.9650013 0.0011099094 7.963334e-01 8.700004e-01 5 146481150 146481175 26 + 1.207 1.230 0.080
ENSG00000113649 E035 17.0921885 0.0010138694 9.441288e-01 9.689816e-01 5 146481176 146481200 25 + 1.225 1.264 0.139
ENSG00000113649 E036 31.1997440 0.0023016603 1.403645e-17 6.762879e-16 5 146481201 146482591 1391 + 1.640 0.954 -2.415
ENSG00000113649 E037 287.8080628 0.0007991197 2.166515e-01 3.463540e-01 5 146482592 146482727 136 + 2.438 2.455 0.057
ENSG00000113649 E038 14.4721228 0.0021871368 2.320640e-03 8.215543e-03 5 146482728 146482808 81 + 1.253 0.997 -0.923
ENSG00000113649 E039 255.7392079 0.0030283323 8.103747e-01 8.796622e-01 5 146483540 146483629 90 + 2.376 2.416 0.135
ENSG00000113649 E040 0.7782011 0.0158523058 8.153703e-01 8.830989e-01 5 146492869 146492919 51 + 0.224 0.288 0.473
ENSG00000113649 E041 287.7633486 0.0002028362 8.544399e-01 9.099453e-01 5 146492920 146493038 119 + 2.425 2.469 0.147
ENSG00000113649 E042 335.0221720 0.0001595930 4.586512e-02 1.017889e-01 5 146498536 146498686 151 + 2.505 2.512 0.024
ENSG00000113649 E043 6.3141033 0.0026712029 3.943060e-03 1.298252e-02 5 146499573 146499971 399 + 0.949 0.582 -1.485
ENSG00000113649 E044 5.8400023 0.0027379927 2.670507e-02 6.537865e-02 5 146503032 146503374 343 + 0.903 0.632 -1.088
ENSG00000113649 E045 215.6974553 0.0009466242 5.757553e-02 1.224600e-01 5 146503375 146503418 44 + 2.320 2.313 -0.022
ENSG00000113649 E046 263.8465955 0.0011158443 7.133067e-01 8.098391e-01 5 146503419 146503470 52 + 2.390 2.428 0.128
ENSG00000113649 E047 302.7481574 0.0003924712 8.187784e-02 1.625069e-01 5 146503471 146503539 69 + 2.460 2.469 0.028
ENSG00000113649 E048 171.5276579 0.0002505090 4.612287e-01 6.012146e-01 5 146503824 146503827 4 + 2.208 2.235 0.090
ENSG00000113649 E049 416.3012055 0.0009104442 4.763155e-01 6.149459e-01 5 146503828 146504006 179 + 2.578 2.643 0.217
ENSG00000113649 E050 1.2618645 0.3809528335 8.542018e-01 9.098094e-01 5 146504007 146504202 196 + 0.280 0.398 0.729
ENSG00000113649 E051 2.9130789 0.0051963842 1.925045e-01 3.169021e-01 5 146504364 146504494 131 + 0.642 0.459 -0.848
ENSG00000113649 E052 0.7469680 0.0171808690 7.748181e-02 1.554189e-01 5 146505505 146505621 117 + 0.328 0.000 -11.413
ENSG00000113649 E053 410.4955419 0.0002323535 5.584038e-03 1.751050e-02 5 146507028 146507207 180 + 2.558 2.658 0.334
ENSG00000113649 E054 2.2875642 0.0450470809 2.525126e-01 3.888680e-01 5 146507208 146507348 141 + 0.569 0.381 -0.943
ENSG00000113649 E055 9.7867108 0.0247251956 4.008046e-04 1.777583e-03 5 146507371 146507744 374 + 1.142 0.676 -1.782
ENSG00000113649 E056 6.0008556 0.0133943672 2.096022e-02 5.350718e-02 5 146507745 146507778 34 + 0.926 0.631 -1.184
ENSG00000113649 E057 2.5978551 0.0068548140 3.160117e-01 4.587799e-01 5 146507779 146507872 94 + 0.595 0.459 -0.643
ENSG00000113649 E058 288.5616902 0.0002069724 6.849187e-04 2.844025e-03 5 146507873 146507956 84 + 2.395 2.518 0.408
ENSG00000113649 E059 292.6573397 0.0007376751 1.156469e-09 1.693904e-08 5 146509145 146509245 101 + 2.368 2.564 0.654
ENSG00000113649 E060 6.9868951 0.0023713697 4.569530e-01 5.973075e-01 5 146510067 146510115 49 + 0.903 0.852 -0.195
ENSG00000113649 E061 8.9128943 0.0020607476 8.244533e-01 8.894103e-01 5 146510116 146510160 45 + 0.949 1.017 0.252
ENSG00000113649 E062 1.1049644 0.1192403582 6.938846e-01 7.948379e-01 5 146510161 146510271 111 + 0.279 0.381 0.638
ENSG00000113649 E063 1467.7603341 0.0057106918 6.254093e-20 3.928445e-18 5 146510441 146511961 1521 + 2.990 3.337 1.155