ENSG00000113648

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000511689 ENSG00000113648 HEK293_OSMI2_2hA HEK293_TMG_2hB MACROH2A1 protein_coding protein_coding 182.2438 213.4916 178.8726 26.79699 3.155313 -0.2552335 72.00807 96.41319 59.81572 9.952039 2.539164 -0.68861427 0.3902417 0.4540667 0.3345 -0.1195667 0.0001070145 0.0001070145 FALSE TRUE
MSTRG.26971.9 ENSG00000113648 HEK293_OSMI2_2hA HEK293_TMG_2hB MACROH2A1 protein_coding   182.2438 213.4916 178.8726 26.79699 3.155313 -0.2552335 76.31929 84.64801 83.04017 11.713292 1.980152 -0.02766345 0.4208375 0.3951000 0.4642 0.0691000 0.0032481760 0.0001070145 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113648 E001 15.3013257 3.928006e-02 2.017347e-01 3.283450e-01 5 135334381 135334382 2 - 1.097 1.257 0.567
ENSG00000113648 E002 108.8746951 2.581650e-04 3.758786e-14 1.135349e-12 5 135334383 135334399 17 - 1.839 2.111 0.915
ENSG00000113648 E003 113.3612964 2.487842e-04 1.686704e-14 5.380386e-13 5 135334400 135334405 6 - 1.858 2.129 0.908
ENSG00000113648 E004 142.6037748 2.303297e-04 1.626536e-09 2.319126e-08 5 135334406 135334409 4 - 2.024 2.206 0.610
ENSG00000113648 E005 209.9217179 2.218170e-04 3.153082e-21 2.319774e-19 5 135334410 135334416 7 - 2.144 2.390 0.822
ENSG00000113648 E006 241.8128669 1.964193e-04 1.361622e-23 1.287844e-21 5 135334417 135334434 18 - 2.207 2.450 0.810
ENSG00000113648 E007 295.1603981 3.080712e-04 3.233521e-24 3.284616e-22 5 135334435 135334472 38 - 2.304 2.533 0.764
ENSG00000113648 E008 2596.7504304 6.614215e-04 2.062446e-18 1.092324e-16 5 135334473 135334855 383 - 3.333 3.432 0.331
ENSG00000113648 E009 1220.1463616 3.800248e-04 3.354375e-11 6.406658e-10 5 135334856 135334912 57 - 3.024 3.101 0.257
ENSG00000113648 E010 2053.0940390 1.034138e-04 4.649697e-18 2.363486e-16 5 135334913 135335100 188 - 3.259 3.324 0.217
ENSG00000113648 E011 1065.0340899 7.684281e-05 3.828990e-04 1.708490e-03 5 135335101 135335141 41 - 2.998 3.028 0.098
ENSG00000113648 E012 14.6898131 7.199933e-03 1.758205e-01 2.957458e-01 5 135339428 135339575 148 - 1.098 1.216 0.422
ENSG00000113648 E013 2.6227441 6.147747e-03 2.206589e-01 3.512074e-01 5 135342663 135342741 79 - 0.661 0.457 -0.940
ENSG00000113648 E014 1909.3401217 6.970929e-05 5.229788e-04 2.245620e-03 5 135343260 135343434 175 - 3.259 3.276 0.060
ENSG00000113648 E015 116.9922127 3.677136e-03 1.512791e-16 6.368748e-15 5 135343435 135345689 2255 - 2.261 1.880 -1.276
ENSG00000113648 E016 20.4893024 9.210117e-04 1.269695e-03 4.876140e-03 5 135345690 135345967 278 - 1.466 1.216 -0.871
ENSG00000113648 E017 1631.5165815 5.936857e-05 3.761253e-01 5.204991e-01 5 135345968 135346057 90 - 3.205 3.201 -0.012
ENSG00000113648 E018 100.0608299 1.169833e-02 1.179262e-01 2.169597e-01 5 135346058 135347606 1549 - 2.063 1.940 -0.412
ENSG00000113648 E019 4.8531526 4.333164e-02 6.986952e-04 2.894378e-03 5 135350814 135350822 9 - 1.023 0.458 -2.354
ENSG00000113648 E020 59.5333777 1.349606e-02 4.941716e-01 6.311471e-01 5 135350823 135350826 4 - 1.808 1.746 -0.209
ENSG00000113648 E021 91.4929380 6.139820e-03 9.875903e-01 9.963151e-01 5 135350827 135350913 87 - 1.960 1.948 -0.041
ENSG00000113648 E022 30.8050376 6.296019e-03 1.737276e-02 4.576156e-02 5 135350914 135351544 631 - 1.598 1.410 -0.643
ENSG00000113648 E023 1350.6963993 5.696483e-04 4.346802e-03 1.411364e-02 5 135352946 135353045 100 - 3.154 3.096 -0.194
ENSG00000113648 E024 243.8621768 1.407557e-02 9.377950e-13 2.312711e-11 5 135353046 135359396 6351 - 2.616 2.132 -1.616
ENSG00000113648 E025 15.3345603 3.378640e-02 5.188621e-02 1.125206e-01 5 135359397 135359628 232 - 1.344 1.078 -0.943
ENSG00000113648 E026 6.6912511 3.443903e-03 9.566593e-04 3.810366e-03 5 135359629 135359721 93 - 1.084 0.675 -1.578
ENSG00000113648 E027 21.2364379 2.606306e-02 5.940350e-01 7.163304e-01 5 135359722 135359942 221 - 1.382 1.298 -0.293
ENSG00000113648 E028 18.9610419 8.657837e-02 1.018984e-03 4.024255e-03 5 135359943 135360415 473 - 1.558 0.977 -2.048
ENSG00000113648 E029 7.1478658 2.752812e-03 5.007656e-09 6.534546e-08 5 135360416 135360496 81 - 1.218 0.496 -2.864
ENSG00000113648 E030 837.5425878 3.896088e-04 1.996699e-04 9.623447e-04 5 135360497 135360518 22 - 2.956 2.886 -0.233
ENSG00000113648 E031 1283.7275278 7.698129e-04 4.263824e-04 1.875667e-03 5 135360519 135360604 86 - 3.141 3.068 -0.243
ENSG00000113648 E032 279.4167275 1.552269e-04 1.722566e-01 2.911417e-01 5 135360605 135360607 3 - 2.464 2.423 -0.136
ENSG00000113648 E033 2.2939070 7.541301e-02 8.741436e-03 2.563924e-02 5 135360608 135360780 173 - 0.762 0.255 -2.583
ENSG00000113648 E034 5.6380577 6.369218e-03 1.771661e-02 4.652370e-02 5 135360781 135362901 2121 - 0.989 0.674 -1.232
ENSG00000113648 E035 0.5943067 2.144616e-02 1.703388e-01 2.886084e-01 5 135369368 135369405 38 - 0.341 0.102 -2.165
ENSG00000113648 E036 1238.4657437 5.499670e-04 9.830799e-06 6.547657e-05 5 135369406 135369480 75 - 3.130 3.050 -0.265
ENSG00000113648 E037 1409.5191697 1.779631e-04 1.397929e-11 2.842190e-10 5 135369481 135369603 123 - 3.192 3.104 -0.293
ENSG00000113648 E038 1318.0085474 7.308272e-04 1.856013e-08 2.177729e-07 5 135370036 135370142 107 - 3.172 3.062 -0.365
ENSG00000113648 E039 3.8717301 2.107022e-02 8.688317e-02 1.704064e-01 5 135370143 135370146 4 - 0.475 0.744 1.191
ENSG00000113648 E040 0.5891098 1.828889e-02 1.540197e-02 4.140331e-02 5 135388917 135388921 5 - 0.413 0.000 -11.596
ENSG00000113648 E041 1556.1780198 2.480515e-03 1.062692e-03 4.175975e-03 5 135388922 135389126 205 - 3.241 3.133 -0.360
ENSG00000113648 E042 2.7239070 5.938367e-03 7.894666e-01 8.652559e-01 5 135389127 135389296 170 - 0.530 0.564 0.160
ENSG00000113648 E043 626.6961052 8.003618e-03 9.760526e-02 1.868327e-01 5 135399062 135399238 177 - 2.845 2.738 -0.356
ENSG00000113648 E044 6.9674399 9.562468e-03 6.365427e-05 3.493470e-04 5 135399749 135399785 37 - 1.150 0.648 -1.927
ENSG00000113648 E045 20.0972046 7.702793e-03 6.865182e-05 3.736356e-04 5 135399786 135399804 19 - 1.505 1.154 -1.226
ENSG00000113648 E046 24.3000561 1.434879e-03 1.886092e-05 1.176770e-04 5 135399805 135399914 110 - 1.566 1.256 -1.072