ENSG00000113645

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393895 ENSG00000113645 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC1 protein_coding protein_coding 14.56173 15.42378 15.24637 0.4344017 0.6089113 -0.01667899 1.0920438 2.124286 0.000000 0.53708864 0.0000000 -7.7376094 0.07610000 0.13913333 0.00000000 -0.13913333 2.748348e-12 2.748348e-12 FALSE TRUE
ENST00000517646 ENSG00000113645 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC1 protein_coding processed_transcript 14.56173 15.42378 15.24637 0.4344017 0.6089113 -0.01667899 0.4776221 0.000000 1.231708 0.00000000 0.6960003 6.9561826 0.03226667 0.00000000 0.07773333 0.07773333 1.828817e-01 2.748348e-12 FALSE FALSE
ENST00000521089 ENSG00000113645 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC1 protein_coding protein_coding 14.56173 15.42378 15.24637 0.4344017 0.6089113 -0.01667899 1.3994219 2.873165 1.292458 0.05548245 0.1032468 -1.1464169 0.09477083 0.18673333 0.08556667 -0.10116667 1.214817e-04 2.748348e-12 FALSE TRUE
ENST00000522140 ENSG00000113645 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC1 protein_coding processed_transcript 14.56173 15.42378 15.24637 0.4344017 0.6089113 -0.01667899 4.4117678 4.937805 4.006857 0.06644529 0.1221898 -0.3007215 0.30363750 0.32060000 0.26386667 -0.05673333 2.474394e-01 2.748348e-12 FALSE TRUE
MSTRG.27272.1 ENSG00000113645 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC1 protein_coding   14.56173 15.42378 15.24637 0.4344017 0.6089113 -0.01667899 1.8737214 1.295525 2.660044 0.49624404 0.1537443 1.0322340 0.12700000 0.08256667 0.17453333 0.09196667 2.628733e-01 2.748348e-12 FALSE TRUE
MSTRG.27272.5 ENSG00000113645 HEK293_OSMI2_2hA HEK293_TMG_2hB WWC1 protein_coding   14.56173 15.42378 15.24637 0.4344017 0.6089113 -0.01667899 4.1314565 3.007166 5.362582 0.36243529 0.1149873 0.8324216 0.28907500 0.19396667 0.35350000 0.15953333 5.905858e-04 2.748348e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113645 E001 8.8194521 0.0831627532 3.135283e-01 4.561456e-01 5 168291613 168291644 32 + 1.069 0.906 -0.602
ENSG00000113645 E002 15.1250161 0.0670195436 6.494684e-02 1.349461e-01 5 168291645 168291682 38 + 1.328 1.075 -0.900
ENSG00000113645 E003 35.2517986 0.0742467470 3.579193e-03 1.195275e-02 5 168291683 168292149 467 + 1.744 1.352 -1.342
ENSG00000113645 E004 36.6571849 0.0006065665 8.330070e-08 8.592545e-07 5 168292150 168292245 96 + 1.725 1.422 -1.035
ENSG00000113645 E005 33.1583587 0.0006431197 9.593166e-06 6.404696e-05 5 168292246 168292271 26 + 1.665 1.404 -0.894
ENSG00000113645 E006 0.2998086 0.0294968880 8.050187e-01   5 168316620 168316804 185 + 0.141 0.106 -0.474
ENSG00000113645 E007 0.1472490 0.0435437896 3.582965e-01   5 168371421 168371423 3 + 0.141 0.000 -11.610
ENSG00000113645 E008 58.4048895 0.0004279171 1.024997e-08 1.261172e-07 5 168371424 168371533 110 + 1.903 1.645 -0.872
ENSG00000113645 E009 102.7964967 0.0003017203 6.403072e-06 4.449084e-05 5 168385211 168385414 204 + 2.093 1.941 -0.512
ENSG00000113645 E010 78.4770219 0.0003591518 5.673733e-03 1.775005e-02 5 168397724 168397800 77 + 1.952 1.846 -0.357
ENSG00000113645 E011 77.0583842 0.0013054413 1.101799e-02 3.120346e-02 5 168399488 168399567 80 + 1.944 1.840 -0.351
ENSG00000113645 E012 65.6037156 0.0026004489 5.063789e-02 1.102933e-01 5 168406198 168406257 60 + 1.866 1.773 -0.313
ENSG00000113645 E013 55.6992819 0.0010708938 7.460359e-02 1.509008e-01 5 168406258 168406272 15 + 1.789 1.706 -0.282
ENSG00000113645 E014 53.2637152 0.0023602758 1.062720e-01 2.000369e-01 5 168406273 168406278 6 + 1.767 1.684 -0.279
ENSG00000113645 E015 75.4134247 0.0003826827 3.565336e-01 5.009138e-01 5 168406279 168406327 49 + 1.890 1.856 -0.115
ENSG00000113645 E016 81.5850458 0.0003696116 1.201475e-02 3.356719e-02 5 168408507 168408584 78 + 1.959 1.864 -0.319
ENSG00000113645 E017 62.5145634 0.0004339467 6.090390e-04 2.566067e-03 5 168408585 168408623 39 + 1.877 1.728 -0.501
ENSG00000113645 E018 55.6408819 0.0004825575 1.003371e-02 2.884455e-02 5 168408624 168408653 30 + 1.813 1.696 -0.396
ENSG00000113645 E019 71.6866962 0.0003410644 5.259556e-05 2.947316e-04 5 168409922 168409995 74 + 1.944 1.781 -0.550
ENSG00000113645 E020 0.0000000       5 168409996 168410180 185 +      
ENSG00000113645 E021 0.0000000       5 168411629 168411686 58 +      
ENSG00000113645 E022 0.2955422 0.0295690126 8.049274e-01   5 168412005 168412129 125 + 0.141 0.106 -0.473
ENSG00000113645 E023 0.2214452 0.0415835427 6.510143e-01   5 168414072 168414129 58 + 0.000 0.106 10.178
ENSG00000113645 E024 0.0000000       5 168414130 168414347 218 +      
ENSG00000113645 E025 107.4190704 0.0002718495 6.003281e-02 1.266612e-01 5 168414348 168414590 243 + 2.057 1.996 -0.204
ENSG00000113645 E026 0.5212538 0.0205375315 7.750838e-01 8.550774e-01 5 168414591 168416522 1932 + 0.141 0.191 0.529
ENSG00000113645 E027 57.9398925 0.0004317205 1.948776e-01 3.198469e-01 5 168422008 168422097 90 + 1.716 1.781 0.222
ENSG00000113645 E028 174.4292939 0.0014093215 8.555391e-01 9.106757e-01 5 168423533 168424068 536 + 2.229 2.227 -0.008
ENSG00000113645 E029 80.8457475 0.0005154953 3.125444e-01 4.550741e-01 5 168428033 168428141 109 + 1.919 1.882 -0.124
ENSG00000113645 E030 0.1817044 0.0401069696 6.522057e-01   5 168428705 168428706 2 + 0.000 0.106 10.191
ENSG00000113645 E031 78.3795293 0.0003733712 3.691309e-01 5.135697e-01 5 168428707 168428787 81 + 1.905 1.872 -0.109
ENSG00000113645 E032 54.7647637 0.0004075127 5.091902e-01 6.445236e-01 5 168430137 168430158 22 + 1.749 1.722 -0.094
ENSG00000113645 E033 67.4556343 0.0010729232 3.131391e-01 4.556703e-01 5 168430159 168430206 48 + 1.845 1.803 -0.142
ENSG00000113645 E034 65.2911468 0.0005335138 5.408740e-01 6.719483e-01 5 168430207 168430223 17 + 1.820 1.797 -0.079
ENSG00000113645 E035 115.5983078 0.0002924846 6.173977e-01 7.352166e-01 5 168431252 168431363 112 + 2.058 2.046 -0.043
ENSG00000113645 E036 108.8989377 0.0004975669 6.794079e-01 7.836045e-01 5 168431364 168431444 81 + 2.014 2.032 0.062
ENSG00000113645 E037 136.6816887 0.0012758286 3.328340e-04 1.511625e-03 5 168441682 168441834 153 + 2.040 2.171 0.436
ENSG00000113645 E038 3.4371585 0.0501461184 1.518752e-01 2.642271e-01 5 168441835 168441849 15 + 0.465 0.730 1.187
ENSG00000113645 E039 59.0330790 0.0004184348 5.460630e-04 2.332161e-03 5 168444494 168444520 27 + 1.650 1.821 0.579
ENSG00000113645 E040 84.1673427 0.0003221008 1.989429e-03 7.193955e-03 5 168444521 168444585 65 + 1.833 1.961 0.431
ENSG00000113645 E041 101.8093666 0.0003587336 1.126857e-02 3.180471e-02 5 168453968 168454100 133 + 1.937 2.033 0.324
ENSG00000113645 E042 107.7720556 0.0003911819 1.464560e-01 2.568657e-01 5 168455356 168455520 165 + 1.986 2.041 0.186
ENSG00000113645 E043 110.2924344 0.0004044671 1.093199e-01 2.045627e-01 5 168460650 168460742 93 + 1.991 2.051 0.202
ENSG00000113645 E044 46.7372218 0.0005043561 3.313120e-01 4.749103e-01 5 168464711 168464728 18 + 1.631 1.686 0.187
ENSG00000113645 E045 169.2467931 0.0002733519 2.161885e-02 5.488424e-02 5 168464729 168464927 199 + 2.175 2.244 0.230
ENSG00000113645 E046 83.3193695 0.0011624842 6.842814e-03 2.081722e-02 5 168464928 168464962 35 + 1.838 1.957 0.403
ENSG00000113645 E047 0.3299976 0.0274424043 3.063903e-01   5 168467693 168467839 147 + 0.000 0.191 11.323
ENSG00000113645 E048 38.4717965 0.0006839197 3.906789e-02 8.932397e-02 5 168467840 168467842 3 + 1.506 1.631 0.427
ENSG00000113645 E049 138.3913716 0.0002796025 9.751380e-07 8.107833e-06 5 168467843 168467964 122 + 2.025 2.185 0.534
ENSG00000113645 E050 414.0006324 0.0019358989 1.898461e-09 2.669867e-08 5 168468951 168472074 3124 + 2.497 2.658 0.536
ENSG00000113645 E051 4.4597337 0.0039022507 2.035566e-01 3.306626e-01 5 168472075 168472303 229 + 0.609 0.796 0.776