ENSG00000113638

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337702 ENSG00000113638 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC33 protein_coding protein_coding 8.214358 1.153933 14.61348 0.1896129 0.4777471 3.651207 2.2214505 0.53273694 4.186847 0.07056006 0.1706278 2.950981 0.4144167 0.4679667 0.2866000 -0.1813667 0.02513891 0.02513891 FALSE TRUE
ENST00000503936 ENSG00000113638 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC33 protein_coding processed_transcript 8.214358 1.153933 14.61348 0.1896129 0.4777471 3.651207 0.9655478 0.29605171 2.377919 0.05671434 0.3152118 2.963906 0.1611458 0.2776667 0.1623667 -0.1153000 0.48841439 0.02513891 FALSE FALSE
ENST00000504251 ENSG00000113638 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC33 protein_coding processed_transcript 8.214358 1.153933 14.61348 0.1896129 0.4777471 3.651207 2.7260435 0.08641626 4.774360 0.08641626 0.7320339 5.632906 0.2254750 0.0864000 0.3241000 0.2377000 0.17215230 0.02513891 FALSE TRUE
ENST00000511730 ENSG00000113638 HEK293_OSMI2_2hA HEK293_TMG_2hB TTC33 protein_coding processed_transcript 8.214358 1.153933 14.61348 0.1896129 0.4777471 3.651207 2.1809883 0.16244154 3.130167 0.16244154 0.6115351 4.186662 0.1684750 0.1061000 0.2172000 0.1111000 0.46181320 0.02513891 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113638 E001 0.9222279 0.0132844738 2.028018e-02 0.0520711730 5 40512333 40513069 737 - 0.130 0.571 2.959
ENSG00000113638 E002 0.1451727 0.0431850422 7.047667e-01   5 40568105 40569581 1477 - 0.048 0.001 -5.946
ENSG00000113638 E003 0.2955422 0.0282241746 1.371072e-01   5 40603932 40604036 105 - 0.048 0.280 2.958
ENSG00000113638 E004 3.0677268 0.0060625981 6.022342e-03 0.0186713789 5 40611492 40613381 1890 - 0.401 0.866 2.066
ENSG00000113638 E005 165.5891230 0.0002369492 2.589533e-05 0.0001564497 5 40711576 40715135 3560 - 2.039 2.173 0.449
ENSG00000113638 E006 90.1232068 0.0003860017 4.209975e-02 0.0949089035 5 40715136 40715943 808 - 1.781 1.878 0.327
ENSG00000113638 E007 44.6733679 0.0279856312 5.845000e-01 0.7084022990 5 40715944 40716144 201 - 1.505 1.427 -0.268
ENSG00000113638 E008 94.1556492 0.0003816592 1.220339e-02 0.0340194802 5 40716145 40716498 354 - 1.831 1.691 -0.474
ENSG00000113638 E009 56.5253525 0.0004339881 1.340608e-01 0.2397928692 5 40728345 40728476 132 - 1.612 1.503 -0.370
ENSG00000113638 E010 47.7361373 0.0044431003 1.987853e-01 0.3246769348 5 40730262 40730343 82 - 1.542 1.436 -0.364
ENSG00000113638 E011 72.7957817 0.0004266931 8.141586e-02 0.1617741236 5 40746798 40747019 222 - 1.722 1.612 -0.372
ENSG00000113638 E012 36.3289408 0.0005772476 9.745157e-03 0.0281362902 5 40755824 40755963 140 - 1.441 1.191 -0.873