ENSG00000113595

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000231524 ENSG00000113595 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM23 protein_coding protein_coding 5.80129 0.8584756 10.02079 0.1030136 0.3175475 3.529807 3.537832 0.8416745 5.720039 0.1010125 0.3769778 2.750171 0.7723708 0.9813333 0.5708667 -0.4104667 2.185919e-08 2.185919e-08 FALSE TRUE
MSTRG.26284.1 ENSG00000113595 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM23 protein_coding   5.80129 0.8584756 10.02079 0.1030136 0.3175475 3.529807 1.873916 0.0000000 3.801574 0.0000000 0.3763507 8.574243 0.1747833 0.0000000 0.3815000 0.3815000 3.193093e-08 2.185919e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113595 E001 1.1823723 0.0113114081 4.823487e-01 6.204981e-01 5 65587332 65587385 54 - 0.263 0.001 -8.813
ENSG00000113595 E002 32.3164329 0.0007230639 3.954648e-08 4.353514e-07 5 65589690 65590129 440 - 1.254 1.689 1.498
ENSG00000113595 E003 17.6676629 0.0012355889 1.181084e-06 9.660760e-06 5 65590130 65590175 46 - 0.993 1.485 1.741
ENSG00000113595 E004 26.0060979 0.0229103595 1.436145e-07 1.415574e-06 5 65590176 65590302 127 - 1.132 1.692 1.942
ENSG00000113595 E005 110.9053729 0.0034660672 8.322371e-10 1.252004e-08 5 65590303 65591447 1145 - 1.799 2.115 1.060
ENSG00000113595 E006 13.0649833 0.0013795560 1.015186e-01 1.927867e-01 5 65591448 65591502 55 - 0.929 1.154 0.824
ENSG00000113595 E007 44.3904763 0.0005257867 1.789846e-01 2.998674e-01 5 65591503 65591842 340 - 1.441 1.564 0.422
ENSG00000113595 E008 29.0385080 0.0009230786 9.139163e-01 9.494960e-01 5 65591843 65591871 29 - 1.278 1.309 0.106
ENSG00000113595 E009 35.2060969 0.0005736931 7.422696e-01 8.312049e-01 5 65591872 65591948 77 - 1.357 1.406 0.170
ENSG00000113595 E010 44.8051480 0.0005121932 7.447395e-01 8.329614e-01 5 65594521 65594645 125 - 1.462 1.455 -0.024
ENSG00000113595 E011 44.4514493 0.0004924312 2.382438e-02 5.945174e-02 5 65596421 65596531 111 - 1.476 1.286 -0.656
ENSG00000113595 E012 41.1736948 0.0110229583 7.212169e-02 1.468676e-01 5 65597051 65597180 130 - 1.442 1.265 -0.617
ENSG00000113595 E013 44.5648431 0.0039930404 5.754197e-02 1.224037e-01 5 65604911 65605045 135 - 1.474 1.309 -0.570
ENSG00000113595 E014 0.0000000       5 65606916 65607167 252 -      
ENSG00000113595 E015 54.8251857 0.0004099285 2.534715e-03 8.867361e-03 5 65609243 65609458 216 - 1.569 1.330 -0.824
ENSG00000113595 E016 19.1146919 0.0016428295 3.633288e-03 1.210736e-02 5 65610861 65610861 1 - 1.146 0.705 -1.674
ENSG00000113595 E017 55.9440516 0.0004109925 1.643502e-07 1.601299e-06 5 65610862 65611043 182 - 1.592 1.087 -1.764
ENSG00000113595 E018 35.4092327 0.0020930612 5.087352e-05 2.861760e-04 5 65611603 65611669 67 - 1.398 0.910 -1.752
ENSG00000113595 E019 33.4124012 0.0007413577 1.801592e-02 4.716751e-02 5 65611670 65611756 87 - 1.361 1.121 -0.844
ENSG00000113595 E020 35.7434279 0.0016250745 3.641374e-01 5.085258e-01 5 65611757 65611881 125 - 1.376 1.309 -0.235
ENSG00000113595 E021 0.1451727 0.0431392926 6.083672e-01   5 65613727 65613855 129 - 0.043 0.001 -5.810
ENSG00000113595 E022 47.3071716 0.0004712868 3.013244e-02 7.222567e-02 5 65614098 65614219 122 - 1.502 1.330 -0.595
ENSG00000113595 E023 48.1279632 0.0006537494 1.684485e-03 6.233434e-03 5 65618093 65618231 139 - 1.515 1.238 -0.960
ENSG00000113595 E024 24.9944808 0.0069873220 1.911823e-01 3.152129e-01 5 65618232 65618255 24 - 1.233 1.087 -0.521
ENSG00000113595 E025 29.9807879 0.0061968571 2.166065e-01 3.463142e-01 5 65624194 65624503 310 - 1.306 1.184 -0.429
ENSG00000113595 E026 0.0000000       5 65625308 65625488 181 -      
ENSG00000113595 E027 0.0000000       5 65625917 65625975 59 -