ENSG00000113580

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394464 ENSG00000113580 HEK293_OSMI2_2hA HEK293_TMG_2hB NR3C1 protein_coding protein_coding 3.847213 0.8703647 6.685109 0.09243938 0.1824912 2.926934 2.5085410 0.83321095 4.110718 0.06941498 0.1655472 2.288930 0.7798000 0.96223333 0.6157333 -0.3465000 6.812390e-06 6.81239e-06 FALSE TRUE
ENST00000424646 ENSG00000113580 HEK293_OSMI2_2hA HEK293_TMG_2hB NR3C1 protein_coding protein_coding 3.847213 0.8703647 6.685109 0.09243938 0.1824912 2.926934 0.3837397 0.00000000 1.096210 0.00000000 0.1893402 6.789481 0.0580125 0.00000000 0.1643667 0.1643667 5.958353e-04 6.81239e-06 FALSE TRUE
ENST00000503201 ENSG00000113580 HEK293_OSMI2_2hA HEK293_TMG_2hB NR3C1 protein_coding protein_coding 3.847213 0.8703647 6.685109 0.09243938 0.1824912 2.926934 0.7269743 0.01464781 1.295088 0.00790780 0.3297443 5.726544 0.1172083 0.01563333 0.1924000 0.1767667 2.491671e-02 6.81239e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113580 E001 0.0000000       5 143277931 143277933 3 -      
ENSG00000113580 E002 0.1482932 0.0406869676 5.709800e-02   5 143277934 143277935 2 - 0.000 0.257 11.646
ENSG00000113580 E003 108.1694674 0.0005125885 7.991725e-21 5.647178e-19 5 143277936 143279411 1476 - 1.833 2.179 1.159
ENSG00000113580 E004 21.4067478 0.0008817737 5.189718e-01 6.531042e-01 5 143279412 143279566 155 - 1.215 1.275 0.212
ENSG00000113580 E005 137.0603234 0.0008131808 1.976885e-06 1.539505e-05 5 143279567 143281119 1553 - 1.979 2.147 0.564
ENSG00000113580 E006 8.2838473 0.0087863467 3.100035e-01 4.523758e-01 5 143281120 143281137 18 - 0.820 0.960 0.535
ENSG00000113580 E007 8.1567843 0.0066792836 1.539953e-01 2.671045e-01 5 143281138 143281161 24 - 0.803 0.997 0.739
ENSG00000113580 E008 9.0413226 0.0019567140 1.525594e-01 2.651600e-01 5 143281162 143281181 20 - 0.845 1.031 0.697
ENSG00000113580 E009 57.7682885 0.0004715882 3.063711e-01 4.485332e-01 5 143281182 143281810 629 - 1.651 1.583 -0.229
ENSG00000113580 E010 37.1337884 0.0008703334 3.577214e-01 5.021395e-01 5 143281811 143282041 231 - 1.465 1.390 -0.262
ENSG00000113580 E011 28.9080907 0.0009212920 9.795329e-02 1.873891e-01 5 143282568 143282725 158 - 1.373 1.215 -0.552
ENSG00000113580 E012 28.0406692 0.0007559700 2.599183e-03 9.062603e-03 5 143295460 143295590 131 - 1.377 1.062 -1.116
ENSG00000113580 E013 23.3825572 0.0014512198 1.112207e-03 4.344416e-03 5 143298668 143298812 145 - 1.308 0.919 -1.405
ENSG00000113580 E014 19.3611602 0.0010863866 2.947184e-01 4.358282e-01 5 143300485 143300560 76 - 1.208 1.092 -0.416
ENSG00000113580 E015 15.0934637 0.0012119415 9.595434e-01 9.785939e-01 5 143300561 143300592 32 - 1.087 1.092 0.016
ENSG00000113580 E016 19.7354942 0.0010713821 2.663514e-01 4.045301e-01 5 143300593 143300685 93 - 1.215 1.092 -0.441
ENSG00000113580 E017 19.5518007 0.0010074676 1.095925e-01 2.049715e-01 5 143300686 143300763 78 - 1.215 1.031 -0.663
ENSG00000113580 E018 22.2430302 0.0009958275 3.367613e-02 7.911019e-02 5 143310097 143310213 117 - 1.270 1.031 -0.856
ENSG00000113580 E019 0.4396707 0.0284871184 1.000000e+00 1.000000e+00 5 143313999 143314001 3 - 0.144 0.000 -12.951
ENSG00000113580 E020 29.6430982 0.0061144014 3.575944e-02 8.311986e-02 5 143314002 143314168 167 - 1.389 1.170 -0.769
ENSG00000113580 E021 0.0000000       5 143389878 143390001 124 -      
ENSG00000113580 E022 30.2878070 0.0259431447 6.172499e-02 1.295290e-01 5 143399656 143399824 169 - 1.401 1.168 -0.818
ENSG00000113580 E023 18.9214124 0.0476463427 5.333526e-02 1.150860e-01 5 143399825 143399902 78 - 1.211 0.880 -1.215
ENSG00000113580 E024 58.6123532 0.0005413898 1.853604e-06 1.452694e-05 5 143399903 143400403 501 - 1.688 1.328 -1.237
ENSG00000113580 E025 9.7867486 0.0217924199 5.587203e-03 1.751926e-02 5 143400404 143400407 4 - 0.971 0.419 -2.362
ENSG00000113580 E026 38.6105722 0.0007050948 2.335074e-03 8.259850e-03 5 143400408 143400852 445 - 1.504 1.236 -0.932
ENSG00000113580 E027 0.0000000       5 143401258 143401397 140 -      
ENSG00000113580 E028 0.0000000       5 143402602 143402737 136 -      
ENSG00000113580 E029 12.4088523 0.0015008989 6.677033e-01 7.748651e-01 5 143403211 143403689 479 - 1.017 0.960 -0.213
ENSG00000113580 E030 1.0393897 0.0120181369 3.353180e-01 4.790940e-01 5 143403785 143403985 201 - 0.282 0.000 -14.111
ENSG00000113580 E031 1.1845624 0.0107132838 2.694415e-01 4.079544e-01 5 143403986 143404129 144 - 0.311 0.000 -14.279
ENSG00000113580 E032 3.1604493 0.0106444268 9.485980e-01 9.717784e-01 5 143404376 143404544 169 - 0.525 0.536 0.050
ENSG00000113580 E033 0.2998086 0.0283292008 1.845142e-01   5 143404619 143404667 49 - 0.053 0.258 2.632
ENSG00000113580 E034 0.2998086 0.0283292008 1.845142e-01   5 143405150 143405323 174 - 0.053 0.258 2.632
ENSG00000113580 E035 0.0000000       5 143408990 143409239 250 -      
ENSG00000113580 E036 0.0000000       5 143433719 143433817 99 -      
ENSG00000113580 E037 0.0000000       5 143433818 143433827 10 -      
ENSG00000113580 E038 0.0000000       5 143434532 143435512 981 -