ENSG00000113569

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000231498 ENSG00000113569 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP155 protein_coding protein_coding 24.6907 10.49422 36.49539 0.8265948 1.223495 1.797141 10.056962 5.8577710 14.21859463 0.5615883 0.29660536 1.277909 0.46462500 0.5574333 0.3901333 -0.1673000 2.967129e-05 1.190202e-44 FALSE TRUE
ENST00000381843 ENSG00000113569 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP155 protein_coding protein_coding 24.6907 10.49422 36.49539 0.8265948 1.223495 1.797141 7.139130 0.2787853 11.32268104 0.2787853 1.70234185 5.294348 0.20908333 0.0263000 0.3077667 0.2814667 2.602657e-02 1.190202e-44 FALSE TRUE
ENST00000502533 ENSG00000113569 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP155 protein_coding processed_transcript 24.6907 10.49422 36.49539 0.8265948 1.223495 1.797141 1.745207 3.8125947 0.03719075 0.3994964 0.03719075 -6.339904 0.15297500 0.3633333 0.0011000 -0.3622333 1.190202e-44 1.190202e-44 FALSE TRUE
ENST00000513532 ENSG00000113569 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP155 protein_coding protein_coding 24.6907 10.49422 36.49539 0.8265948 1.223495 1.797141 2.067154 0.0000000 4.75668560 0.0000000 0.70655682 8.896843 0.05749167 0.0000000 0.1316333 0.1316333 1.476433e-13 1.190202e-44 FALSE TRUE
MSTRG.26073.3 ENSG00000113569 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP155 protein_coding   24.6907 10.49422 36.49539 0.8265948 1.223495 1.797141 2.500470 0.0000000 4.73230036 0.0000000 0.28069796 8.889443 0.06915833 0.0000000 0.1300333 0.1300333 5.946357e-23 1.190202e-44 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113569 E001 906.6153480 0.0094639621 5.730437e-12 1.240560e-10 5 37288137 37291619 3483 - 2.783 3.119 1.119
ENSG00000113569 E002 14.5860476 0.0014965937 1.659405e-03 6.152161e-03 5 37291620 37291632 13 - 1.021 1.355 1.188
ENSG00000113569 E003 60.6076392 0.0006615269 4.361540e-04 1.913395e-03 5 37291633 37291837 205 - 1.658 1.877 0.743
ENSG00000113569 E004 36.1614496 0.0012419454 1.759498e-01 2.959318e-01 5 37291838 37291838 1 - 1.467 1.600 0.454
ENSG00000113569 E005 82.4470988 0.0004482901 8.045805e-06 5.459753e-05 5 37291839 37291899 61 - 1.787 2.022 0.790
ENSG00000113569 E006 151.5712638 0.0004261409 8.867151e-21 6.233229e-19 5 37291900 37292038 139 - 2.012 2.349 1.127
ENSG00000113569 E007 185.8485474 0.0001908871 3.714310e-28 5.334836e-26 5 37292879 37292985 107 - 2.096 2.443 1.160
ENSG00000113569 E008 0.3666179 0.0362902118 3.624802e-01 5.068965e-01 5 37292986 37293174 189 - 0.067 0.214 1.937
ENSG00000113569 E009 213.3281761 0.0020835904 1.366421e-12 3.273450e-11 5 37294329 37294465 137 - 2.181 2.461 0.936
ENSG00000113569 E010 182.3161984 0.0017524114 1.895035e-13 5.184991e-12 5 37298868 37298978 111 - 2.109 2.401 0.976
ENSG00000113569 E011 199.8529844 0.0036664774 4.938577e-05 2.786344e-04 5 37299448 37299568 121 - 2.180 2.383 0.678
ENSG00000113569 E012 0.5964967 0.0205366729 9.252870e-01 9.569641e-01 5 37301014 37301436 423 - 0.176 0.214 0.346
ENSG00000113569 E013 199.2294654 0.0034278172 1.123414e-02 3.172462e-02 5 37301437 37301550 114 - 2.198 2.341 0.478
ENSG00000113569 E014 206.2429817 0.0002425287 1.182062e-03 4.580634e-03 5 37302779 37302908 130 - 2.215 2.350 0.452
ENSG00000113569 E015 219.2549542 0.0001846296 8.697762e-02 1.705566e-01 5 37303260 37303414 155 - 2.254 2.346 0.306
ENSG00000113569 E016 0.5943067 0.0246429240 9.288515e-01 9.592486e-01 5 37303415 37303416 2 - 0.176 0.214 0.346
ENSG00000113569 E017 162.0492009 0.0001945827 7.749909e-02 1.554470e-01 5 37304739 37304843 105 - 2.120 2.221 0.337
ENSG00000113569 E018 217.4584593 0.0002321841 5.302702e-01 6.629104e-01 5 37305057 37305210 154 - 2.257 2.320 0.209
ENSG00000113569 E019 197.5501249 0.0002507246 6.565592e-01 7.660713e-01 5 37307297 37307432 136 - 2.224 2.256 0.106
ENSG00000113569 E020 188.6289459 0.0002375983 8.477839e-04 3.429794e-03 5 37309129 37309267 139 - 2.227 2.168 -0.198
ENSG00000113569 E021 0.2955422 0.0289783558 3.668183e-01   5 37309404 37309572 169 - 0.067 0.213 1.930
ENSG00000113569 E022 205.7729317 0.0002040585 3.187037e-03 1.081743e-02 5 37310552 37310743 192 - 2.260 2.217 -0.142
ENSG00000113569 E023 172.5269921 0.0002092797 2.070185e-03 7.442350e-03 5 37314198 37314328 131 - 2.186 2.131 -0.185
ENSG00000113569 E024 148.2103686 0.0025010620 1.923162e-02 4.983680e-02 5 37317988 37318085 98 - 2.119 2.061 -0.196
ENSG00000113569 E025 152.9167449 0.0002428868 2.046693e-06 1.588772e-05 5 37323992 37324107 116 - 2.147 2.022 -0.419
ENSG00000113569 E026 141.3079677 0.0010591699 1.747043e-06 1.376699e-05 5 37325901 37325967 67 - 2.118 1.969 -0.498
ENSG00000113569 E027 199.4071493 0.0002210822 4.318992e-11 8.102794e-10 5 37327629 37327776 148 - 2.270 2.103 -0.555
ENSG00000113569 E028 140.0455966 0.0002682223 7.033657e-06 4.842304e-05 5 37328358 37328420 63 - 2.110 1.987 -0.412
ENSG00000113569 E029 129.2452270 0.0008079941 2.722634e-04 1.266842e-03 5 37329190 37329278 89 - 2.070 1.967 -0.346
ENSG00000113569 E030 102.4595702 0.0027694358 5.979399e-04 2.525988e-03 5 37330038 37330132 95 - 1.975 1.843 -0.442
ENSG00000113569 E031 124.2396604 0.0002710911 1.882463e-09 2.649925e-08 5 37331685 37331795 111 - 2.072 1.870 -0.677
ENSG00000113569 E032 156.1282920 0.0007259886 6.501725e-12 1.395098e-10 5 37333463 37333633 171 - 2.172 1.948 -0.749
ENSG00000113569 E033 111.2796323 0.0148175499 2.222074e-04 1.058846e-03 5 37337818 37337918 101 - 2.029 1.787 -0.812
ENSG00000113569 E034 138.3796120 0.0002276304 3.580579e-14 1.084981e-12 5 37341090 37341242 153 - 2.127 1.870 -0.862
ENSG00000113569 E035 0.7394793 0.0153787590 9.301596e-01 9.600642e-01 5 37342397 37342548 152 - 0.222 0.214 -0.068
ENSG00000113569 E036 108.9192960 0.0002478954 2.516838e-09 3.465170e-08 5 37342549 37342646 98 - 2.018 1.801 -0.729
ENSG00000113569 E037 94.4492774 0.0003189642 3.525874e-09 4.721195e-08 5 37348505 37348596 92 - 1.961 1.725 -0.795
ENSG00000113569 E038 78.8577311 0.0035114193 6.268927e-04 2.631691e-03 5 37349172 37349245 74 - 1.869 1.714 -0.522
ENSG00000113569 E039 109.4161084 0.0044886123 6.394592e-07 5.537488e-06 5 37350160 37350265 106 - 2.023 1.791 -0.780
ENSG00000113569 E040 146.0189881 0.0337066130 9.458359e-05 4.966122e-04 5 37351190 37351356 167 - 2.161 1.826 -1.123
ENSG00000113569 E041 119.1954836 0.0129595282 3.337841e-08 3.725588e-07 5 37352737 37352829 93 - 2.077 1.721 -1.200
ENSG00000113569 E042 122.2915656 0.0045879423 1.828284e-12 4.293045e-11 5 37358081 37358151 71 - 2.088 1.738 -1.176
ENSG00000113569 E043 120.4056601 0.0002896084 2.132993e-24 2.197330e-22 5 37363888 37363984 97 - 2.089 1.658 -1.452
ENSG00000113569 E044 146.0295625 0.0031348352 2.438109e-20 1.621244e-18 5 37364247 37364384 138 - 2.172 1.740 -1.450
ENSG00000113569 E045 7.5998207 0.0023080788 1.248734e-03 4.805967e-03 5 37370666 37370820 155 - 0.954 0.464 -2.067
ENSG00000113569 E046 122.9596385 0.0063862634 2.378105e-15 8.565111e-14 5 37370821 37371126 306 - 2.100 1.645 -1.532