ENSG00000113558

Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328392 ENSG00000113558 HEK293_OSMI2_2hA HEK293_TMG_2hB SKP1 protein_coding protein_coding 199.2082 192.6994 225.6888 29.38924 5.619515 0.227972 106.93206 92.56557 128.192332 11.0942566 2.588441 0.46971914 0.53449167 0.48483333 0.56816667 0.08333333 0.014480762 0.004554783 FALSE  
ENST00000517625 ENSG00000113558 HEK293_OSMI2_2hA HEK293_TMG_2hB SKP1 protein_coding protein_coding 199.2082 192.6994 225.6888 29.38924 5.619515 0.227972 12.06994 26.35174 5.034549 8.4900364 3.587130 -2.38564848 0.06019583 0.13046667 0.02216667 -0.10830000 0.288715592 0.004554783 FALSE  
ENST00000521216 ENSG00000113558 HEK293_OSMI2_2hA HEK293_TMG_2hB SKP1 protein_coding protein_coding 199.2082 192.6994 225.6888 29.38924 5.619515 0.227972 48.63800 53.47387 50.974027 9.7448652 1.675329 -0.06905861 0.24710417 0.27526667 0.22580000 -0.04946667 0.005640071 0.004554783 FALSE  
ENST00000522855 ENSG00000113558 HEK293_OSMI2_2hA HEK293_TMG_2hB SKP1 protein_coding protein_coding 199.2082 192.6994 225.6888 29.38924 5.619515 0.227972 21.34215 16.57393 29.255592 0.3559282 2.060738 0.81941990 0.10187083 0.08983333 0.12943333 0.03960000 0.202983394 0.004554783 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.