ENSG00000113552

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311337 ENSG00000113552 HEK293_OSMI2_2hA HEK293_TMG_2hB GNPDA1 protein_coding protein_coding 50.5292 60.54769 41.38208 5.986048 1.793926 -0.5489556 46.00076 56.51564 36.23439 5.492988 1.253379 -0.6411477 0.9068625 0.9339 0.8762667 -0.05763333 0.007306802 6.129589e-18 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113552 E001 0.000000       5 141991749 141991920 172 -      
ENSG00000113552 E002 4.546058 0.0640141953 5.079960e-04 2.189922e-03 5 142000671 142000673 3 - 0.148 0.876 4.007
ENSG00000113552 E003 4.915796 0.0337930838 8.894446e-05 4.700999e-04 5 142000674 142000677 4 - 0.148 0.906 4.121
ENSG00000113552 E004 1957.686846 0.0022773226 1.099814e-07 1.108928e-06 5 142000678 142002085 1408 - 3.191 3.310 0.394
ENSG00000113552 E005 217.331503 0.0002024479 2.441593e-01 3.790916e-01 5 142002086 142002089 4 - 2.325 2.326 0.006
ENSG00000113552 E006 269.300086 0.0002216878 9.699116e-01 9.851797e-01 5 142002090 142002129 40 - 2.397 2.427 0.098
ENSG00000113552 E007 453.551671 0.0001287009 7.079209e-01 8.056819e-01 5 142003088 142003214 127 - 2.627 2.651 0.080
ENSG00000113552 E008 225.843562 0.0001660679 2.550615e-01 3.918662e-01 5 142003215 142003217 3 - 2.339 2.341 0.010
ENSG00000113552 E009 295.077058 0.0001624808 2.437539e-01 3.785925e-01 5 142003218 142003262 45 - 2.453 2.459 0.019
ENSG00000113552 E010 1.167621 0.1163361856 3.867036e-01 5.308800e-01 5 142004875 142004931 57 - 0.418 0.254 -1.028
ENSG00000113552 E011 276.924230 0.0001613668 3.784978e-01 5.227893e-01 5 142004932 142004985 54 - 2.422 2.433 0.038
ENSG00000113552 E012 271.306736 0.0001862945 2.489774e-01 3.847153e-01 5 142004986 142005043 58 - 2.418 2.423 0.017
ENSG00000113552 E013 308.342431 0.0005057090 7.337293e-02 1.489178e-01 5 142005044 142005111 68 - 2.482 2.472 -0.034
ENSG00000113552 E014 186.992244 0.0002574809 7.910952e-03 2.355419e-02 5 142005112 142005116 5 - 2.285 2.245 -0.135
ENSG00000113552 E015 3.567336 0.1857698562 3.074136e-01 4.496424e-01 5 142005117 142005441 325 - 0.799 0.526 -1.168
ENSG00000113552 E016 2.466977 0.0057612552 4.650388e-02 1.029485e-01 5 142006036 142006143 108 - 0.703 0.410 -1.369
ENSG00000113552 E017 500.140693 0.0001594627 1.007505e-08 1.241262e-07 5 142006144 142006326 183 - 2.724 2.661 -0.211
ENSG00000113552 E018 355.068062 0.0001731441 5.553338e-05 3.093394e-04 5 142007799 142007900 102 - 2.566 2.517 -0.161
ENSG00000113552 E019 1.887429 0.0377266084 4.913493e-01 6.286276e-01 5 142011849 142011911 63 - 0.346 0.490 0.784
ENSG00000113552 E020 206.242832 0.0021893158 2.456741e-01 3.808380e-01 5 142011912 142011948 37 - 2.307 2.293 -0.046
ENSG00000113552 E021 222.874823 0.0099314521 2.936290e-01 4.346951e-01 5 142011949 142012041 93 - 2.354 2.316 -0.129
ENSG00000113552 E022 3.223494 0.0128440194 5.199250e-02 1.127124e-01 5 142012042 142012287 246 - 0.768 0.490 -1.216
ENSG00000113552 E023 7.513707 0.0022163098 1.527232e-02 4.110437e-02 5 142012288 142012339 52 - 1.062 0.812 -0.939
ENSG00000113552 E024 2.176720 0.0065834659 1.136865e-02 3.204517e-02 5 142012340 142012377 38 - 0.703 0.311 -1.953
ENSG00000113552 E025 4.192373 0.0037150778 2.603337e-03 9.074914e-03 5 142012378 142012668 291 - 0.918 0.525 -1.631
ENSG00000113552 E026 17.626639 0.0162511402 4.668797e-01 6.064099e-01 5 142012669 142012914 246 - 1.284 1.230 -0.188
ENSG00000113552 E027 4.345028 0.0342954397 8.752546e-01 9.238804e-01 5 142012915 142012994 80 - 0.703 0.696 -0.031
ENSG00000113552 E028 89.663837 0.0534472667 4.052906e-01 5.489775e-01 5 142012995 142013041 47 - 1.987 1.905 -0.275