ENSG00000113448

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340635 ENSG00000113448 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE4D protein_coding protein_coding 0.6286618 0.2934021 0.9480664 0.0215484 0.02140212 1.658894 0.12343518 0.074365815 0.2446962 0.028710905 0.007491118 1.5940470 0.2182500 0.24190000 0.2584667 0.01656667 1.0000000000 0.0007253164 FALSE TRUE
ENST00000358923 ENSG00000113448 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE4D protein_coding protein_coding 0.6286618 0.2934021 0.9480664 0.0215484 0.02140212 1.658894 0.06986282 0.009650229 0.1285703 0.009650229 0.072301538 2.8179996 0.0889625 0.03776667 0.1328667 0.09510000 0.7272407751 0.0007253164 FALSE TRUE
ENST00000502575 ENSG00000113448 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE4D protein_coding protein_coding 0.6286618 0.2934021 0.9480664 0.0215484 0.02140212 1.658894 0.10572907 0.190749165 0.1663230 0.019615505 0.011297264 -0.1871733 0.2288292 0.64740000 0.1758333 -0.47156667 0.0007253164 0.0007253164 FALSE TRUE
ENST00000515011 ENSG00000113448 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE4D protein_coding retained_intron 0.6286618 0.2934021 0.9480664 0.0215484 0.02140212 1.658894 0.09210410 0.000000000 0.1590540 0.000000000 0.050365731 4.0794119 0.1103375 0.00000000 0.1677000 0.16770000 0.1237305336 0.0007253164 FALSE TRUE
ENST00000636120 ENSG00000113448 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE4D protein_coding protein_coding 0.6286618 0.2934021 0.9480664 0.0215484 0.02140212 1.658894 0.19659303 0.018636924 0.2240824 0.018636924 0.039375225 3.0310678 0.2954750 0.07293333 0.2378000 0.16486667 0.2636165566 0.0007253164 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113448 E001 5.9495581 0.003083492 0.36383288 0.50825909 5 58969038 58970286 1249 - 0.751 0.869 0.467
ENSG00000113448 E002 30.6676808 0.075563488 0.90706614 0.94500530 5 58970287 58973687 3401 - 1.439 1.424 -0.052
ENSG00000113448 E003 0.9662231 0.020302984 0.84252032 0.90187506 5 58973688 58973771 84 - 0.262 0.215 -0.368
ENSG00000113448 E004 2.4681968 0.013783739 0.55841667 0.68665613 5 58973772 58974017 246 - 0.450 0.553 0.497
ENSG00000113448 E005 6.7458184 0.082694197 0.87911567 0.92636623 5 58974018 58974560 543 - 0.822 0.798 -0.093
ENSG00000113448 E006 2.0399544 0.013998311 0.66296775 0.77114085 5 58974561 58974562 2 - 0.450 0.358 -0.506
ENSG00000113448 E007 2.7202123 0.014382141 0.79995960 0.87245586 5 58974563 58974654 92 - 0.521 0.466 -0.268
ENSG00000113448 E008 0.8275069 0.588034330 0.81320705 0.88156994 5 58974655 58974656 2 - 0.222 0.221 -0.010
ENSG00000113448 E009 4.4876556 0.009118484 0.15231147 0.26483609 5 58974657 58974920 264 - 0.724 0.466 -1.162
ENSG00000113448 E010 4.2771436 0.007423237 0.17725682 0.29766230 5 58974921 58975080 160 - 0.711 0.466 -1.106
ENSG00000113448 E011 4.5393764 0.004684129 0.03526118 0.08214817 5 58975657 58975839 183 - 0.751 0.358 -1.855
ENSG00000113448 E012 3.5899914 0.019337012 0.02551911 0.06294864 5 58976350 58976472 123 - 0.682 0.215 -2.571
ENSG00000113448 E013 3.1741538 0.013415014 0.18664054 0.30952144 5 58977191 58977345 155 - 0.617 0.358 -1.295
ENSG00000113448 E014 1.6888644 0.050992380 0.85792572 0.91229851 5 58988493 58988592 100 - 0.396 0.358 -0.215
ENSG00000113448 E015 1.4435834 0.009980660 0.36180903 0.50623069 5 58989755 58989919 165 - 0.299 0.466 0.952
ENSG00000113448 E016 0.7771569 0.015857596 1.00000000 1.00000000 5 58990804 58990902 99 - 0.221 0.215 -0.048
ENSG00000113448 E017 1.6930170 0.016261204 0.86074080 0.91416826 5 58991832 58992004 173 - 0.396 0.358 -0.217
ENSG00000113448 E018 1.5499206 0.015125727 0.98566478 0.99507185 5 58993372 58993424 53 - 0.366 0.358 -0.047
ENSG00000113448 E019 1.4026716 0.013299816 0.88538403 0.93068857 5 58993425 58993465 41 - 0.334 0.358 0.145
ENSG00000113448 E020 0.0000000       5 58999489 58999932 444 -      
ENSG00000113448 E021 2.7689384 0.005911430 0.69645868 0.79680418 5 59038859 59038971 113 - 0.542 0.465 -0.370
ENSG00000113448 E022 0.7406253 0.015378759 0.28722645 0.42771054 5 59038972 59039057 86 - 0.262 0.000 -13.962
ENSG00000113448 E023 2.4098091 0.006574229 0.11427516 0.21177257 5 59039058 59039515 458 - 0.542 0.215 -1.955
ENSG00000113448 E024 0.0000000       5 59091082 59091125 44 -      
ENSG00000113448 E025 0.6652806 0.017959705 0.01957612 0.05057532 5 59157066 59157362 297 - 0.066 0.465 3.536
ENSG00000113448 E026 0.0000000       5 59164947 59165050 104 -      
ENSG00000113448 E027 0.0000000       5 59166261 59166434 174 -      
ENSG00000113448 E028 0.0000000       5 59172802 59172879 78 -      
ENSG00000113448 E029 0.0000000       5 59174350 59174472 123 -      
ENSG00000113448 E030 0.0000000       5 59180593 59180594 2 -      
ENSG00000113448 E031 1.7077908 0.008974546 0.22017719 0.35064399 5 59180595 59180644 50 - 0.334 0.551 1.143
ENSG00000113448 E032 1.5908325 0.008752790 0.46728497 0.60679367 5 59185189 59185262 74 - 0.334 0.466 0.730
ENSG00000113448 E033 1.8164423 0.008496460 0.01258396 0.03493115 5 59193500 59193536 37 - 0.262 0.685 2.215
ENSG00000113448 E034 0.0000000       5 59215454 59215776 323 -      
ENSG00000113448 E035 3.0300478 0.005251136 0.03014582 0.07225317 5 59215777 59215968 192 - 0.450 0.787 1.492
ENSG00000113448 E036 0.0000000       5 59216744 59216754 11 -      
ENSG00000113448 E037 0.0000000       5 59216818 59216826 9 -      
ENSG00000113448 E038 0.1451727 0.047515225 1.00000000   5 59275338 59276119 782 - 0.066 0.000 -11.996
ENSG00000113448 E039 0.3332198 0.033186412 0.31498253   5 59356758 59356975 218 - 0.067 0.215 1.952
ENSG00000113448 E040 0.0000000       5 59430294 59430600 307 -      
ENSG00000113448 E041 0.0000000       5 59558560 59558793 234 -      
ENSG00000113448 E042 0.0000000       5 59560830 59560914 85 -      
ENSG00000113448 E043 0.0000000       5 59586329 59586499 171 -      
ENSG00000113448 E044 2.9538744 0.005746056 0.02050424 0.05255316 5 59768247 59768645 399 - 0.424 0.787 1.631
ENSG00000113448 E045 0.0000000       5 59797060 59797132 73 -      
ENSG00000113448 E046 0.0000000       5 59893168 59893726 559 -      
ENSG00000113448 E047 0.1451727 0.047515225 1.00000000   5 59986398 59988158 1761 - 0.066 0.000 -11.996
ENSG00000113448 E048 0.1451727 0.047515225 1.00000000   5 59988159 59988234 76 - 0.066 0.000 -11.996
ENSG00000113448 E049 0.0000000       5 59988235 59988317 83 -      
ENSG00000113448 E050 0.0000000       5 59988318 59988320 3 -      
ENSG00000113448 E051 0.0000000       5 59988321 59988360 40 -      
ENSG00000113448 E052 0.0000000       5 59988361 59988440 80 -      
ENSG00000113448 E053 0.0000000       5 59988441 59988487 47 -      
ENSG00000113448 E054 0.0000000       5 59988488 59988516 29 -      
ENSG00000113448 E055 0.0000000       5 59988517 59988535 19 -      
ENSG00000113448 E056 0.0000000       5 59988536 59988601 66 -      
ENSG00000113448 E057 0.0000000       5 59988602 59988717 116 -      
ENSG00000113448 E058 0.0000000       5 60127584 60127681 98 -      
ENSG00000113448 E059 0.0000000       5 60147748 60147894 147 -      
ENSG00000113448 E060 0.0000000       5 60160769 60160817 49 -      
ENSG00000113448 E061 0.0000000       5 60185557 60185687 131 -      
ENSG00000113448 E062 0.0000000       5 60188296 60188418 123 -      
ENSG00000113448 E063 0.0000000       5 60262398 60262559 162 -      
ENSG00000113448 E064 0.0000000       5 60335082 60335130 49 -      
ENSG00000113448 E065 0.0000000       5 60372534 60372714 181 -      
ENSG00000113448 E066 0.0000000       5 60448637 60448707 71 -      
ENSG00000113448 E067 0.0000000       5 60487942 60488098 157 -      
ENSG00000113448 E068 0.0000000       5 60522051 60522120 70 -