ENSG00000113430

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000231357 ENSG00000113430 HEK293_OSMI2_2hA HEK293_TMG_2hB IRX4 protein_coding protein_coding 0.1500213 0.2166142 0.2215097 0.0467612 0.1268677 0.03083448 0.077458356 0.16227632 0.000000000 0.08973157 0.000000000 -4.1066525 0.35392727 0.6666667 0.00000 -0.6666667 0.643299137 0.001178437 FALSE TRUE
ENST00000505938 ENSG00000113430 HEK293_OSMI2_2hA HEK293_TMG_2hB IRX4 protein_coding processed_transcript 0.1500213 0.2166142 0.2215097 0.0467612 0.1268677 0.03083448 0.020114372 0.00000000 0.160914979 0.00000000 0.088140454 4.0952069 0.06756818 0.0000000 0.74325 0.7432500 0.001178437 0.001178437 FALSE FALSE
ENST00000508261 ENSG00000113430 HEK293_OSMI2_2hA HEK293_TMG_2hB IRX4 protein_coding nonsense_mediated_decay 0.1500213 0.2166142 0.2215097 0.0467612 0.1268677 0.03083448 0.008115962 0.00000000 0.008491708 0.00000000 0.008491708 0.8868785 0.15121818 0.0000000 0.05660 0.0566000 0.833676753 0.001178437 FALSE TRUE
ENST00000511126 ENSG00000113430 HEK293_OSMI2_2hA HEK293_TMG_2hB IRX4 protein_coding protein_coding 0.1500213 0.2166142 0.2215097 0.0467612 0.1268677 0.03083448 0.004463770 0.00000000 0.035710160 0.00000000 0.035710160 2.1925149 0.01108182 0.0000000 0.12190 0.1219000 0.694486561 0.001178437 FALSE FALSE
ENST00000513692 ENSG00000113430 HEK293_OSMI2_2hA HEK293_TMG_2hB IRX4 protein_coding protein_coding 0.1500213 0.2166142 0.2215097 0.0467612 0.1268677 0.03083448 0.039868822 0.05433785 0.016392843 0.05433785 0.008516954 -1.2855211 0.41620455 0.3333333 0.07825 -0.2550833 0.952346969 0.001178437 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113430 E001 0.0000000       5 1877413 1877426 14 -      
ENSG00000113430 E002 0.0000000       5 1877427 1877447 21 -      
ENSG00000113430 E003 3.3838995 0.006337542 0.19832656 0.32412609 5 1877448 1877813 366 - 0.339 0.607 1.364
ENSG00000113430 E004 3.6514152 0.005282553 0.16074321 0.27608880 5 1877814 1878784 971 - 0.339 0.626 1.448
ENSG00000113430 E005 0.0000000       5 1878785 1878792 8 -      
ENSG00000113430 E006 2.0995131 0.070855467 0.03191909 0.07569981 5 1879504 1879669 166 - 0.658 0.321 -1.701
ENSG00000113430 E007 2.6572855 0.007426799 0.07192109 0.14652366 5 1879670 1879832 163 - 0.658 0.417 -1.136
ENSG00000113430 E008 0.1515154 0.602579026 0.11857929   5 1879833 1879870 38 - 0.202 0.000 -11.911
ENSG00000113430 E009 0.0000000       5 1880066 1880143 78 -      
ENSG00000113430 E010 1.2177675 0.015751448 0.22187617 0.35263529 5 1880725 1880834 110 - 0.000 0.353 11.221
ENSG00000113430 E011 0.2214452 1.329308407 0.71217855   5 1881005 1881093 89 - 0.000 0.076 8.680
ENSG00000113430 E012 1.2866677 0.087175989 0.74169485 0.83075278 5 1881808 1882059 252 - 0.339 0.314 -0.154
ENSG00000113430 E013 0.6966155 0.019165571 0.73573901 0.82642745 5 1882603 1882747 145 - 0.202 0.187 -0.138
ENSG00000113430 E014 0.9609220 0.023582417 0.42375218 0.56679110 5 1882748 1882925 178 - 0.000 0.278 10.758
ENSG00000113430 E015 0.0000000       5 1886862 1887061 200 -      
ENSG00000113430 E016 0.0000000       5 1887062 1887236 175 -