ENSG00000113369

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265138 ENSG00000113369 HEK293_OSMI2_2hA HEK293_TMG_2hB ARRDC3 protein_coding protein_coding 2.753212 0.4393176 4.124513 0.06918739 0.3920951 3.20191 1.9473295 0.4393176 3.0709205 0.06918739 0.1364335 2.777554 0.80481250 1 0.7539333 -0.2460667 0.004105152 0.004105152 FALSE TRUE
ENST00000511391 ENSG00000113369 HEK293_OSMI2_2hA HEK293_TMG_2hB ARRDC3 protein_coding retained_intron 2.753212 0.4393176 4.124513 0.06918739 0.3920951 3.20191 0.4485811 0.0000000 0.4925789 0.00000000 0.2796129 5.651278 0.08472083 0 0.1132667 0.1132667 0.617546555 0.004105152   FALSE
ENST00000514284 ENSG00000113369 HEK293_OSMI2_2hA HEK293_TMG_2hB ARRDC3 protein_coding processed_transcript 2.753212 0.4393176 4.124513 0.06918739 0.3920951 3.20191 0.1691692 0.0000000 0.4519467 0.00000000 0.1038780 5.529654 0.03893750 0 0.1105000 0.1105000 0.066619897 0.004105152   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113369 E001 100.9712592 0.0195621676 2.044679e-08 2.380082e-07 5 91368631 91370797 2167 - 1.748 2.141 1.323
ENSG00000113369 E002 37.2533372 0.0007144416 7.085864e-04 2.929913e-03 5 91370798 91371456 659 - 1.409 1.206 -0.709
ENSG00000113369 E003 19.5026353 0.0063051972 5.434250e-02 1.168468e-01 5 91373684 91373838 155 - 1.138 1.002 -0.495
ENSG00000113369 E004 1.7820913 0.0081066067 1.647833e-01 2.814084e-01 5 91373839 91373845 7 - 0.355 0.000 -10.622
ENSG00000113369 E005 16.8651229 0.0077597978 1.889349e-01 3.124113e-01 5 91374114 91374224 111 - 1.070 1.003 -0.245
ENSG00000113369 E006 10.6819335 0.0054282185 3.488210e-01 4.930360e-01 5 91374225 91374276 52 - 0.889 0.847 -0.160
ENSG00000113369 E007 11.1015439 0.0016297363 4.925747e-01 6.297274e-01 5 91374922 91374999 78 - 0.901 0.905 0.018
ENSG00000113369 E008 16.5702501 0.0029884523 5.247440e-03 1.660395e-02 5 91375000 91375178 179 - 1.085 0.780 -1.151
ENSG00000113369 E009 0.0000000       5 91375179 91375344 166 -      
ENSG00000113369 E010 6.2013998 0.0029062655 6.351305e-01 7.494852e-01 5 91375511 91375520 10 - 0.690 0.701 0.045
ENSG00000113369 E011 6.2162753 0.0030581817 6.359344e-01 7.500846e-01 5 91375521 91375526 6 - 0.690 0.701 0.045
ENSG00000113369 E012 10.7410037 0.0026446139 3.215091e-01 4.647692e-01 5 91375527 91375613 87 - 0.895 0.847 -0.182
ENSG00000113369 E013 0.0000000       5 91376559 91376620 62 -      
ENSG00000113369 E014 11.3246136 0.0019679900 4.442150e-01 5.857738e-01 5 91376621 91376768 148 - 0.912 0.905 -0.025
ENSG00000113369 E015 9.5451929 0.0020902812 2.819055e-01 4.218596e-01 5 91378694 91378775 82 - 0.852 0.780 -0.281
ENSG00000113369 E016 0.5933762 0.0211050912 1.000000e+00 1.000000e+00 5 91379882 91379922 41 - 0.153 0.000 -9.077
ENSG00000113369 E017 1.3403442 0.0191158595 2.858127e-01 4.261714e-01 5 91379923 91380151 229 - 0.290 0.000 -10.226
ENSG00000113369 E018 0.1451727 0.0442757151 7.525244e-01   5 91380780 91381020 241 - 0.043 0.000 -7.114
ENSG00000113369 E019 13.0670422 0.0015162124 5.982239e-04 2.527018e-03 5 91382813 91383317 505 - 1.003 0.479 -2.172