ENSG00000113368

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261366 ENSG00000113368 HEK293_OSMI2_2hA HEK293_TMG_2hB LMNB1 protein_coding protein_coding 111.6824 92.28533 142.5263 5.64352 3.175617 0.6269997 45.62335 30.57835 78.73220 1.767438 2.563549 1.364155 0.40361667 0.3355333 0.5528333 0.2173000 1.008037e-03 2.823286e-71 FALSE TRUE
ENST00000472034 ENSG00000113368 HEK293_OSMI2_2hA HEK293_TMG_2hB LMNB1 protein_coding processed_transcript 111.6824 92.28533 142.5263 5.64352 3.175617 0.6269997 10.45970 0.00000 28.25982 0.000000 2.408314 11.465047 0.07169167 0.0000000 0.1978667 0.1978667 2.823286e-71 2.823286e-71 FALSE FALSE
ENST00000504788 ENSG00000113368 HEK293_OSMI2_2hA HEK293_TMG_2hB LMNB1 protein_coding processed_transcript 111.6824 92.28533 142.5263 5.64352 3.175617 0.6269997 29.05129 18.03035 33.38961 16.239626 5.683512 0.888604 0.27797500 0.1764333 0.2341333 0.0577000 6.415460e-01 2.823286e-71 FALSE TRUE
MSTRG.26852.7 ENSG00000113368 HEK293_OSMI2_2hA HEK293_TMG_2hB LMNB1 protein_coding   111.6824 92.28533 142.5263 5.64352 3.175617 0.6269997 18.04076 43.45112 0.00000 9.415748 0.000000 -12.085510 0.18562500 0.4855667 0.0000000 -0.4855667 1.928641e-18 2.823286e-71 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113368 E001 0.0000000       5 126776375 126776416 42 +      
ENSG00000113368 E002 0.0000000       5 126776417 126776622 206 +      
ENSG00000113368 E003 3.8883734 1.922635e-01 2.520373e-01 3.883601e-01 5 126776623 126777135 513 + 0.799 0.516 -1.213
ENSG00000113368 E004 7.4074123 5.918548e-03 1.102079e-02 3.120929e-02 5 126777136 126777152 17 + 1.045 0.743 -1.154
ENSG00000113368 E005 32.8451360 6.604795e-04 1.343134e-03 5.120185e-03 5 126777153 126777160 8 + 1.611 1.426 -0.631
ENSG00000113368 E006 97.7180915 3.872962e-04 5.479356e-08 5.854752e-07 5 126777161 126777188 28 + 2.074 1.886 -0.632
ENSG00000113368 E007 186.3632465 2.120991e-03 2.026618e-06 1.574672e-05 5 126777189 126777244 56 + 2.339 2.186 -0.510
ENSG00000113368 E008 171.1573990 2.775830e-03 2.221909e-03 7.911402e-03 5 126777245 126777252 8 + 2.282 2.177 -0.349
ENSG00000113368 E009 314.3885139 1.643667e-03 5.377912e-08 5.757399e-07 5 126777253 126777360 108 + 2.561 2.419 -0.473
ENSG00000113368 E010 203.5303157 2.242459e-04 1.180366e-11 2.428506e-10 5 126777361 126777378 18 + 2.380 2.218 -0.541
ENSG00000113368 E011 227.6977911 2.257082e-03 4.332244e-08 4.731799e-07 5 126777379 126777406 28 + 2.431 2.258 -0.576
ENSG00000113368 E012 492.1563503 1.188549e-02 7.469289e-07 6.375752e-06 5 126777407 126777697 291 + 2.798 2.532 -0.887
ENSG00000113368 E013 410.6058827 6.950880e-03 2.347778e-07 2.220789e-06 5 126777698 126777867 170 + 2.705 2.482 -0.740
ENSG00000113368 E014 685.2549495 1.044916e-03 4.680530e-08 5.078827e-07 5 126804776 126804932 157 + 2.881 2.781 -0.335
ENSG00000113368 E015 893.6684374 7.074795e-04 2.825706e-09 3.855116e-08 5 126805571 126805696 126 + 2.992 2.902 -0.299
ENSG00000113368 E016 1233.9072037 7.733679e-05 6.111738e-07 5.316361e-06 5 126810180 126810350 171 + 3.111 3.073 -0.125
ENSG00000113368 E017 0.1482932 4.085178e-02 3.787244e-01   5 126811713 126811772 60 + 0.000 0.139 9.719
ENSG00000113368 E018 1033.7095589 7.169167e-05 2.577843e-05 1.557881e-04 5 126811773 126811898 126 + 3.032 2.999 -0.110
ENSG00000113368 E019 1.8154127 1.205257e-02 4.812793e-01 6.195094e-01 5 126815170 126815247 78 + 0.511 0.399 -0.571
ENSG00000113368 E020 1315.7750327 6.949700e-05 8.762304e-02 1.715275e-01 5 126818922 126819142 221 + 3.123 3.120 -0.010
ENSG00000113368 E021 2.0898490 7.983656e-03 8.405303e-01 9.004717e-01 5 126819143 126819234 92 + 0.471 0.514 0.210
ENSG00000113368 E022 1302.1290086 1.048145e-04 1.274220e-01 2.305608e-01 5 126820910 126821135 226 + 3.103 3.133 0.099
ENSG00000113368 E023 942.2728675 1.260766e-04 2.093440e-04 1.003938e-03 5 126822781 126822885 105 + 2.948 3.008 0.198
ENSG00000113368 E024 878.7706617 3.435127e-04 6.681892e-10 1.024328e-08 5 126825988 126826107 120 + 2.895 2.998 0.343
ENSG00000113368 E025 807.8383772 1.281052e-04 9.997616e-27 1.255980e-24 5 126832694 126832801 108 + 2.831 2.985 0.514
ENSG00000113368 E026 2123.9067409 2.274388e-03 2.139885e-25 2.430425e-23 5 126836223 126837020 798 + 3.200 3.435 0.781