ENSG00000113360

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344624 ENSG00000113360 HEK293_OSMI2_2hA HEK293_TMG_2hB DROSHA protein_coding protein_coding 38.47542 52.0417 32.29096 4.783739 1.28933 -0.6883684 2.197692 2.7236034 2.0612246 0.35403427 0.368387441 -0.4003200 0.05759583 0.0534000 0.063700000 0.010300000 7.857147e-01 1.031522e-62 FALSE TRUE
ENST00000504133 ENSG00000113360 HEK293_OSMI2_2hA HEK293_TMG_2hB DROSHA protein_coding retained_intron 38.47542 52.0417 32.29096 4.783739 1.28933 -0.6883684 3.482574 9.2864669 2.0235843 0.75645598 1.083418017 -2.1926577 0.07861667 0.1800000 0.060766667 -0.119233333 4.910295e-01 1.031522e-62 FALSE FALSE
ENST00000511778 ENSG00000113360 HEK293_OSMI2_2hA HEK293_TMG_2hB DROSHA protein_coding retained_intron 38.47542 52.0417 32.29096 4.783739 1.28933 -0.6883684 1.655398 6.1019850 0.0000000 2.00225361 0.000000000 -9.2554972 0.03380833 0.1125667 0.000000000 -0.112566667 2.232413e-14 1.031522e-62 FALSE TRUE
ENST00000513349 ENSG00000113360 HEK293_OSMI2_2hA HEK293_TMG_2hB DROSHA protein_coding protein_coding 38.47542 52.0417 32.29096 4.783739 1.28933 -0.6883684 4.360168 0.0000000 6.9291085 0.00000000 0.577976855 9.4386065 0.13225417 0.0000000 0.214366667 0.214366667 1.031522e-62 1.031522e-62 FALSE TRUE
ENST00000514927 ENSG00000113360 HEK293_OSMI2_2hA HEK293_TMG_2hB DROSHA protein_coding retained_intron 38.47542 52.0417 32.29096 4.783739 1.28933 -0.6883684 3.716411 11.7337748 0.1689178 3.52615870 0.001501174 -6.0364558 0.07708750 0.2173000 0.005233333 -0.212066667 6.074577e-19 1.031522e-62   FALSE
MSTRG.26026.11 ENSG00000113360 HEK293_OSMI2_2hA HEK293_TMG_2hB DROSHA protein_coding   38.47542 52.0417 32.29096 4.783739 1.28933 -0.6883684 2.047571 0.1023112 3.2913422 0.07613731 0.575446068 4.8774792 0.06159583 0.0020000 0.102666667 0.100666667 2.900922e-07 1.031522e-62 FALSE TRUE
MSTRG.26026.4 ENSG00000113360 HEK293_OSMI2_2hA HEK293_TMG_2hB DROSHA protein_coding   38.47542 52.0417 32.29096 4.783739 1.28933 -0.6883684 3.649017 5.1789941 1.9692361 0.26029374 0.364240401 -1.3905112 0.09556250 0.1008000 0.062100000 -0.038700000 2.301731e-01 1.031522e-62 FALSE TRUE
MSTRG.26026.6 ENSG00000113360 HEK293_OSMI2_2hA HEK293_TMG_2hB DROSHA protein_coding   38.47542 52.0417 32.29096 4.783739 1.28933 -0.6883684 5.253249 6.2766909 4.0866782 0.29296205 0.741953937 -0.6178462 0.13436250 0.1233000 0.126766667 0.003466667 1.000000e+00 1.031522e-62 FALSE TRUE
MSTRG.26026.7 ENSG00000113360 HEK293_OSMI2_2hA HEK293_TMG_2hB DROSHA protein_coding   38.47542 52.0417 32.29096 4.783739 1.28933 -0.6883684 9.641482 9.5049169 8.6764927 1.44534776 0.142285589 -0.1314173 0.25926667 0.1891667 0.269800000 0.080633333 3.596012e-01 1.031522e-62 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113360 E001 0.1817044 0.0399047715 5.677657e-01   5 31400494 31400496 3 - 0.000 0.114 11.114
ENSG00000113360 E002 33.6534247 0.0066658954 7.347360e-01 8.256334e-01 5 31400497 31401133 637 - 1.521 1.553 0.109
ENSG00000113360 E003 10.8852351 0.0024893979 5.110184e-02 1.111338e-01 5 31401134 31401146 13 - 0.944 1.151 0.756
ENSG00000113360 E004 19.1382196 0.0018280109 4.502528e-05 2.564922e-04 5 31401147 31401207 61 - 1.065 1.417 1.241
ENSG00000113360 E005 31.2786101 0.0462381946 9.394593e-03 2.726721e-02 5 31401208 31401300 93 - 1.297 1.604 1.059
ENSG00000113360 E006 198.7292169 0.0078306892 4.837528e-13 1.248406e-11 5 31401301 31401411 111 - 2.033 2.415 1.276
ENSG00000113360 E007 385.6065769 0.0047291542 8.972802e-21 6.305158e-19 5 31401412 31401550 139 - 2.329 2.699 1.232
ENSG00000113360 E008 203.6721385 0.0034940699 1.220297e-22 1.045598e-20 5 31401551 31401562 12 - 2.031 2.431 1.336
ENSG00000113360 E009 2.5966195 0.2261932970 6.935810e-01 7.946060e-01 5 31405603 31405676 74 - 0.584 0.551 -0.151
ENSG00000113360 E010 278.2947963 0.0066629354 8.940115e-14 2.559586e-12 5 31405677 31405723 47 - 2.201 2.554 1.178
ENSG00000113360 E011 358.2835635 0.0037465559 1.640231e-14 5.242734e-13 5 31406853 31406945 93 - 2.365 2.645 0.932
ENSG00000113360 E012 1.6585973 0.0081312747 7.292398e-01 8.214669e-01 5 31406946 31407050 105 - 0.383 0.446 0.343
ENSG00000113360 E013 3.1291118 0.0134939161 3.389658e-02 7.954432e-02 5 31408736 31409055 320 - 0.775 0.446 -1.464
ENSG00000113360 E014 299.2756434 0.0004154145 1.607034e-20 1.093170e-18 5 31409056 31409159 104 - 2.331 2.551 0.735
ENSG00000113360 E015 242.2882638 0.0001802516 8.674471e-16 3.304549e-14 5 31409250 31409332 83 - 2.253 2.452 0.664
ENSG00000113360 E016 5.9442595 0.0029043603 1.742083e-03 6.414750e-03 5 31409333 31409551 219 - 1.023 0.633 -1.538
ENSG00000113360 E017 330.5461813 0.0010173270 2.374510e-09 3.285210e-08 5 31410746 31410887 142 - 2.418 2.572 0.513
ENSG00000113360 E018 239.6057745 0.0026842498 1.230971e-04 6.280905e-04 5 31421272 31421323 52 - 2.291 2.428 0.459
ENSG00000113360 E019 234.7694377 0.0011823665 1.225718e-06 9.988759e-06 5 31421324 31421377 54 - 2.276 2.421 0.483
ENSG00000113360 E020 0.3299976 0.0274424043 2.529008e-01   5 31421751 31421867 117 - 0.000 0.203 12.143
ENSG00000113360 E021 331.7482711 0.0005311867 5.845933e-07 5.104838e-06 5 31422787 31422944 158 - 2.445 2.562 0.391
ENSG00000113360 E022 0.2944980 0.3856295558 2.431479e-01   5 31422945 31423321 377 - 0.232 0.000 -12.903
ENSG00000113360 E023 170.9781140 0.0002578170 1.182212e-02 3.310833e-02 5 31424427 31424471 45 - 2.185 2.261 0.254
ENSG00000113360 E024 221.3245522 0.0003574892 1.575700e-01 2.718859e-01 5 31429475 31429545 71 - 2.316 2.357 0.137
ENSG00000113360 E025 280.0412910 0.0001725041 1.564487e-01 2.703870e-01 5 31431576 31431678 103 - 2.422 2.458 0.121
ENSG00000113360 E026 278.5289252 0.0001833597 6.464223e-02 1.344504e-01 5 31435765 31435864 100 - 2.412 2.458 0.153
ENSG00000113360 E027 201.8938310 0.0002989358 3.650893e-01 5.094243e-01 5 31437239 31437298 60 - 2.283 2.311 0.095
ENSG00000113360 E028 0.6266857 0.0172671820 8.574143e-01 9.119400e-01 5 31437299 31437324 26 - 0.232 0.204 -0.243
ENSG00000113360 E029 193.7443313 0.0020781729 5.832374e-01 7.073879e-01 5 31448547 31448607 61 - 2.271 2.294 0.076
ENSG00000113360 E030 0.9609220 0.1461959275 4.264680e-02 9.590024e-02 5 31449277 31449280 4 - 0.000 0.400 13.484
ENSG00000113360 E031 215.7582139 0.0012632685 5.280076e-01 6.609279e-01 5 31449281 31449368 88 - 2.316 2.338 0.075
ENSG00000113360 E032 154.3968219 0.0002339574 8.917613e-01 9.348867e-01 5 31449369 31449419 51 - 2.184 2.186 0.004
ENSG00000113360 E033 200.3085835 0.0006012072 8.309691e-01 8.940357e-01 5 31451533 31451640 108 - 2.296 2.295 -0.005
ENSG00000113360 E034 1.6617072 0.0083488245 2.316565e-01 3.644288e-01 5 31464088 31464235 148 - 0.541 0.341 -1.051
ENSG00000113360 E035 217.1906669 0.0013637177 5.686539e-03 1.778335e-02 5 31464236 31464343 108 - 2.376 2.298 -0.261
ENSG00000113360 E036 207.0245447 0.0004547033 8.501744e-05 4.517262e-04 5 31466182 31466281 100 - 2.366 2.269 -0.327
ENSG00000113360 E037 2.3441406 0.1316153550 5.757438e-01 7.012669e-01 5 31466282 31466486 205 - 0.585 0.450 -0.646
ENSG00000113360 E038 0.9016039 0.2289980497 1.295505e-01 2.335267e-01 5 31467142 31467166 25 - 0.444 0.112 -2.590
ENSG00000113360 E039 1.4477361 0.0198880763 2.150993e-01 3.445595e-01 5 31467459 31467517 59 - 0.495 0.278 -1.242
ENSG00000113360 E040 1.4424506 0.1320713696 6.046064e-01 7.250793e-01 5 31467518 31467612 95 - 0.443 0.341 -0.571
ENSG00000113360 E041 1.1093300 0.2182620667 5.697788e-01 6.962978e-01 5 31467613 31467938 326 - 0.233 0.349 0.796
ENSG00000113360 E042 76.6245608 0.0003665023 2.281715e-02 5.736217e-02 5 31467939 31467944 6 - 1.934 1.848 -0.292
ENSG00000113360 E043 85.9280264 0.0003129044 6.842863e-02 1.407710e-01 5 31467945 31467962 18 - 1.972 1.908 -0.215
ENSG00000113360 E044 200.5507843 0.0002046853 3.357317e-06 2.487002e-05 5 31467963 31468063 101 - 2.360 2.248 -0.376
ENSG00000113360 E045 167.7741598 0.0002789790 7.345630e-04 3.023797e-03 5 31472063 31472126 64 - 2.270 2.181 -0.298
ENSG00000113360 E046 183.4225785 0.0022147551 3.661717e-02 8.474447e-02 5 31472127 31472232 106 - 2.296 2.227 -0.230
ENSG00000113360 E047 0.0000000       5 31472233 31472233 1 -      
ENSG00000113360 E048 166.0425288 0.0013984435 9.332781e-03 2.711510e-02 5 31483554 31483628 75 - 2.260 2.179 -0.271
ENSG00000113360 E049 164.3274452 0.0007267340 2.850721e-04 1.319119e-03 5 31484881 31484962 82 - 2.270 2.166 -0.348
ENSG00000113360 E050 167.0868807 0.0047684473 3.690027e-03 1.226730e-02 5 31486491 31486562 72 - 2.285 2.165 -0.403
ENSG00000113360 E051 0.0000000       5 31486673 31486733 61 -      
ENSG00000113360 E052 1.0319011 0.0120990628 2.847950e-02 6.897402e-02 5 31488982 31489083 102 - 0.495 0.114 -2.828
ENSG00000113360 E053 98.5556352 0.0018419816 5.424488e-04 2.318816e-03 5 31493207 31493208 2 - 2.066 1.930 -0.456
ENSG00000113360 E054 170.3304333 0.0025858173 1.141915e-06 9.366252e-06 5 31493209 31493293 85 - 2.320 2.146 -0.579
ENSG00000113360 E055 148.9449805 0.0013152333 5.267838e-08 5.651693e-07 5 31495286 31495372 87 - 2.264 2.086 -0.594
ENSG00000113360 E056 148.1296970 0.0003665931 3.962541e-12 8.805766e-11 5 31504555 31504635 81 - 2.275 2.073 -0.675
ENSG00000113360 E057 190.5558865 0.0088467735 1.067013e-04 5.528910e-04 5 31508621 31508775 155 - 2.380 2.184 -0.656
ENSG00000113360 E058 178.3221036 0.0056390083 3.904940e-05 2.256525e-04 5 31511035 31511176 142 - 2.343 2.164 -0.601
ENSG00000113360 E059 86.1773698 0.0002999668 2.145083e-08 2.486719e-07 5 31514988 31514993 6 - 2.044 1.836 -0.698
ENSG00000113360 E060 218.6107669 0.0030079294 1.703279e-10 2.889595e-09 5 31514994 31515219 226 - 2.452 2.229 -0.743
ENSG00000113360 E061 68.8327828 0.0004675410 1.568380e-07 1.534181e-06 5 31515454 31515564 111 - 1.952 1.732 -0.740
ENSG00000113360 E062 109.4997839 0.0073365065 1.093831e-08 1.338823e-07 5 31521123 31521215 93 - 2.189 1.886 -1.015
ENSG00000113360 E063 218.7399101 0.0061668141 1.613270e-09 2.301252e-08 5 31526079 31526328 250 - 2.471 2.204 -0.892
ENSG00000113360 E064 199.4101029 0.0074373055 6.979675e-06 4.808985e-05 5 31526329 31526754 426 - 2.407 2.193 -0.716
ENSG00000113360 E065 116.1441911 0.0049578861 2.354840e-07 2.226579e-06 5 31526755 31526906 152 - 2.186 1.946 -0.806
ENSG00000113360 E066 52.8821685 0.0015769705 4.867185e-05 2.750406e-04 5 31526907 31526912 6 - 1.832 1.629 -0.685
ENSG00000113360 E067 0.6192988 0.0220899017 2.388328e-01 3.727799e-01 5 31527504 31527580 77 - 0.314 0.114 -1.826
ENSG00000113360 E068 98.5066736 0.0038162418 1.002949e-08 1.236211e-07 5 31529040 31529105 66 - 2.125 1.864 -0.876
ENSG00000113360 E069 152.3897196 0.0123450166 7.535794e-07 6.428755e-06 5 31530798 31530924 127 - 2.329 2.030 -0.999
ENSG00000113360 E070 113.2195623 0.0092973169 2.455883e-10 4.049610e-09 5 31531450 31531525 76 - 2.227 1.866 -1.210
ENSG00000113360 E071 93.3062704 0.0081496729 1.747909e-10 2.958687e-09 5 31531990 31532109 120 - 2.143 1.781 -1.218
ENSG00000113360 E072 1.4424375 0.0093541648 5.503267e-01 6.799750e-01 5 31532114 31532196 83 - 0.442 0.342 -0.565