ENSG00000113356

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000504930 ENSG00000113356 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR3G protein_coding protein_coding 9.500423 9.847601 10.49629 1.162519 0.3795658 0.09194434 0.7017752 0.000000 1.9745708 0.0000000 0.9933237 7.6326832 0.07475417 0.0000000 0.18716667 0.18716667 1.873976e-01 2.749563e-08 FALSE  
ENST00000514483 ENSG00000113356 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR3G protein_coding protein_coding 9.500423 9.847601 10.49629 1.162519 0.3795658 0.09194434 3.3695832 5.916637 2.9860830 1.0683154 0.9801919 -0.9841361 0.39486250 0.5935000 0.28036667 -0.31313333 5.237462e-02 2.749563e-08 FALSE  
ENST00000651687 ENSG00000113356 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR3G protein_coding protein_coding 9.500423 9.847601 10.49629 1.162519 0.3795658 0.09194434 2.4733269 1.039073 3.0608657 0.1528445 0.7444649 1.5495299 0.23007917 0.1101667 0.29256667 0.18240000 6.760370e-02 2.749563e-08 FALSE  
MSTRG.26557.6 ENSG00000113356 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR3G protein_coding   9.500423 9.847601 10.49629 1.162519 0.3795658 0.09194434 1.9041299 2.566926 0.9415486 0.2600721 0.9415486 -1.4373018 0.19357500 0.2637333 0.09196667 -0.17176667 1.416685e-01 2.749563e-08 FALSE  
MSTRG.26557.8 ENSG00000113356 HEK293_OSMI2_2hA HEK293_TMG_2hB POLR3G protein_coding   9.500423 9.847601 10.49629 1.162519 0.3795658 0.09194434 0.6747858 0.000000 0.9279894 0.0000000 0.2357990 6.5514997 0.06812500 0.0000000 0.08933333 0.08933333 2.749563e-08 2.749563e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113356 E001 0.4772466 0.0209266073 2.505708e-01 3.866161e-01 5 90471748 90471926 179 + 0.098 0.264 1.732
ENSG00000113356 E002 1.9509172 0.0073220487 2.199804e-02 5.567382e-02 5 90474059 90474260 202 + 0.303 0.639 1.732
ENSG00000113356 E003 1.6971948 0.0221615949 8.645157e-01 9.166666e-01 5 90474261 90474318 58 + 0.442 0.427 -0.077
ENSG00000113356 E004 0.0000000       5 90474864 90474866 3 +      
ENSG00000113356 E005 4.0877671 0.0089902587 9.877829e-03 2.846468e-02 5 90474867 90474888 22 + 0.547 0.863 1.317
ENSG00000113356 E006 4.2329398 0.0063755906 1.519618e-02 4.093144e-02 5 90474889 90474894 6 + 0.577 0.863 1.180
ENSG00000113356 E007 50.8148520 0.0158712454 3.302135e-03 1.115513e-02 5 90474895 90475020 126 + 1.649 1.788 0.472
ENSG00000113356 E008 1.4664887 0.1357694969 2.396957e-02 5.974245e-02 5 90478401 90478455 55 + 0.546 0.000 -11.771
ENSG00000113356 E009 29.5201801 0.0009334165 2.900607e-04 1.339553e-03 5 90485525 90485534 10 + 1.410 1.569 0.544
ENSG00000113356 E010 95.0990153 0.0011305369 3.639891e-17 1.649680e-15 5 90485535 90485684 150 + 1.870 2.100 0.770
ENSG00000113356 E011 90.3291996 0.0003997678 2.285021e-23 2.101410e-21 5 90488000 90488129 130 + 1.824 2.100 0.929
ENSG00000113356 E012 40.2036654 0.0041798804 2.273606e-35 5.674940e-33 5 90490593 90490858 266 + 1.165 1.897 2.514
ENSG00000113356 E013 18.9895865 0.0116879427 5.526986e-09 7.157991e-08 5 90495677 90495733 57 + 1.478 0.749 -2.656
ENSG00000113356 E014 17.3431927 0.0020509382 1.178815e-11 2.425579e-10 5 90497656 90497706 51 + 1.447 0.639 -3.008
ENSG00000113356 E015 0.4502799 0.0331776332 2.578707e-01 3.950576e-01 5 90497707 90497735 29 + 0.245 0.000 -10.038
ENSG00000113356 E016 10.7932170 0.0015697270 5.911339e-08 6.273868e-07 5 90501906 90501908 3 + 1.253 0.491 -3.011
ENSG00000113356 E017 25.9330346 0.0009147793 5.283107e-19 3.005612e-17 5 90501909 90501988 80 + 1.625 0.716 -3.293
ENSG00000113356 E018 35.5809731 0.0015414686 1.980672e-19 1.187444e-17 5 90506528 90506674 147 + 1.744 0.973 -2.699
ENSG00000113356 E019 208.0736152 0.0093076533 5.775082e-15 1.968818e-13 5 90512053 90514557 2505 + 2.443 2.035 -1.362