ENSG00000113328

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340828 ENSG00000113328 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNG1 protein_coding protein_coding 74.86958 36.04412 104.2029 4.439178 4.436163 1.531298 54.720381 18.65067 78.700341 0.6598946 4.3571121 2.076552 0.67724583 0.5344333 0.7547333 0.2203000 2.840604e-02 2.497624e-07 FALSE TRUE
ENST00000509425 ENSG00000113328 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNG1 protein_coding processed_transcript 74.86958 36.04412 104.2029 4.439178 4.436163 1.531298 5.615461 14.72783 1.395120 3.3148819 0.8853692 -3.390759 0.15374583 0.3985333 0.0134000 -0.3851333 1.191066e-02 2.497624e-07   FALSE
ENST00000511683 ENSG00000113328 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNG1 protein_coding processed_transcript 74.86958 36.04412 104.2029 4.439178 4.436163 1.531298 3.841610 0.00000 5.147337 0.0000000 1.7030973 9.010482 0.04532917 0.0000000 0.0500000 0.0500000 2.497624e-07 2.497624e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113328 E001 0.3666179 0.0304478242 3.380863e-01 4.819516e-01 5 163437569 163437570 2 + 0.065 0.219 2.024
ENSG00000113328 E002 0.3666179 0.0304478242 3.380863e-01 4.819516e-01 5 163437571 163437582 12 + 0.065 0.219 2.024
ENSG00000113328 E003 1.9855525 0.0082784365 5.918343e-01 7.145154e-01 5 163437583 163437594 12 + 0.444 0.364 -0.439
ENSG00000113328 E004 17.6470106 0.0011655741 1.693227e-03 6.261134e-03 5 163437595 163437606 12 + 1.254 0.948 -1.109
ENSG00000113328 E005 46.2783874 0.0004861015 3.787416e-03 1.254703e-02 5 163437607 163437613 7 + 1.634 1.484 -0.511
ENSG00000113328 E006 136.4641843 0.0015928900 6.370103e-06 4.429175e-05 5 163437614 163437664 51 + 2.097 1.942 -0.520
ENSG00000113328 E007 135.5324045 0.0029602490 2.563023e-05 1.549716e-04 5 163437665 163437668 4 + 2.094 1.935 -0.535
ENSG00000113328 E008 127.3457670 0.0049638823 2.699662e-04 1.257512e-03 5 163437669 163437669 1 + 2.066 1.911 -0.521
ENSG00000113328 E009 206.8613036 0.0059629987 2.389316e-04 1.128749e-03 5 163437670 163437750 81 + 2.273 2.129 -0.482
ENSG00000113328 E010 131.0939327 0.0088576537 3.276494e-02 7.733505e-02 5 163437751 163437764 14 + 2.066 1.972 -0.316
ENSG00000113328 E011 118.0181920 0.0090990734 2.509395e-02 6.206881e-02 5 163437765 163437765 1 + 2.022 1.917 -0.352
ENSG00000113328 E012 120.8069378 0.0093635807 3.103174e-02 7.397935e-02 5 163437766 163437768 3 + 2.031 1.931 -0.337
ENSG00000113328 E013 174.3817417 0.0021486350 2.639954e-03 9.190211e-03 5 163437769 163437793 25 + 2.188 2.107 -0.270
ENSG00000113328 E014 161.7816829 0.0027458676 2.011523e-02 5.173037e-02 5 163437794 163437804 11 + 2.151 2.091 -0.200
ENSG00000113328 E015 2.5894241 0.0057058085 3.066612e-01 4.488469e-01 5 163439191 163439256 66 + 0.534 0.364 -0.887
ENSG00000113328 E016 314.3077456 0.0014427169 2.320827e-06 1.780272e-05 5 163439257 163439346 90 + 2.447 2.340 -0.356
ENSG00000113328 E017 450.2783826 0.0015776160 1.956027e-13 5.334150e-12 5 163439347 163439520 174 + 2.613 2.440 -0.577
ENSG00000113328 E018 1.2597021 0.3288025447 8.390079e-01 8.993856e-01 5 163439521 163439602 82 + 0.295 0.365 0.439
ENSG00000113328 E019 346.5822486 0.0015873911 3.657132e-09 4.882197e-08 5 163441078 163441177 100 + 2.495 2.351 -0.481
ENSG00000113328 E020 257.9185967 0.0018376646 3.816899e-06 2.790169e-05 5 163441178 163441210 33 + 2.363 2.240 -0.411
ENSG00000113328 E021 433.1148322 0.0001296426 2.755989e-09 3.769503e-08 5 163441211 163441331 121 + 2.582 2.496 -0.284
ENSG00000113328 E022 1.6305864 0.0516742798 5.311844e-01 6.636723e-01 5 163441656 163441885 230 + 0.329 0.474 0.803
ENSG00000113328 E023 346.9457368 0.0001991472 8.362217e-03 2.469481e-02 5 163441886 163441964 79 + 2.472 2.451 -0.069
ENSG00000113328 E024 364.0291549 0.0001470138 1.407492e-02 3.839382e-02 5 163442045 163442143 99 + 2.491 2.477 -0.047
ENSG00000113328 E025 629.4096548 0.0001362897 4.978707e-01 6.344004e-01 5 163442374 163442568 195 + 2.719 2.749 0.100
ENSG00000113328 E026 466.7721759 0.0001147868 4.814553e-01 6.196813e-01 5 163443674 163443756 83 + 2.583 2.638 0.183
ENSG00000113328 E027 380.3991321 0.0001841286 7.281990e-01 8.207071e-01 5 163443757 163443795 39 + 2.499 2.533 0.112
ENSG00000113328 E028 523.9211328 0.0001790998 1.959585e-01 3.211619e-01 5 163443796 163443925 130 + 2.630 2.695 0.216
ENSG00000113328 E029 678.0079688 0.0012704564 3.641300e-05 2.119499e-04 5 163443926 163444336 411 + 2.724 2.856 0.441
ENSG00000113328 E030 409.4913107 0.0017071970 4.978753e-22 3.983149e-20 5 163444337 163444481 145 + 2.451 2.750 0.996
ENSG00000113328 E031 905.9759846 0.0082101450 3.361160e-12 7.569683e-11 5 163444482 163445016 535 + 2.782 3.114 1.104
ENSG00000113328 E032 2.3699509 0.0078875642 1.096471e-01 2.050452e-01 5 163445904 163445981 78 + 0.390 0.693 1.434
ENSG00000113328 E033 2.2226899 0.0917735990 5.752122e-01 7.008852e-01 5 163445982 163446151 170 + 0.418 0.560 0.701
ENSG00000113328 E034 0.4460135 0.0392472540 5.627761e-01 6.903274e-01 5 163446676 163446723 48 + 0.172 0.000 -8.885