ENSG00000113318

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265081 ENSG00000113318 HEK293_OSMI2_2hA HEK293_TMG_2hB MSH3 protein_coding protein_coding 8.795604 3.082455 13.24025 0.2865308 0.56253 2.099195 3.532077 1.6373546 5.620501 0.5171868 0.1487175 1.7731123 0.4312833 0.56963333 0.42616667 -0.14346667 7.688250e-01 7.592211e-09 FALSE TRUE
ENST00000658259 ENSG00000113318 HEK293_OSMI2_2hA HEK293_TMG_2hB MSH3 protein_coding protein_coding 8.795604 3.082455 13.24025 0.2865308 0.56253 2.099195 2.838200 0.9769552 1.413918 0.5068143 1.4139176 0.5288091 0.2990208 0.29576667 0.09893333 -0.19683333 4.103157e-01 7.592211e-09 FALSE TRUE
ENST00000659302 ENSG00000113318 HEK293_OSMI2_2hA HEK293_TMG_2hB MSH3 protein_coding nonsense_mediated_decay 8.795604 3.082455 13.24025 0.2865308 0.56253 2.099195 0.280928 0.2653058 0.000000 0.2653058 0.0000000 -4.7829632 0.0636625 0.07296667 0.00000000 -0.07296667 5.478812e-01 7.592211e-09 FALSE TRUE
MSTRG.26496.1 ENSG00000113318 HEK293_OSMI2_2hA HEK293_TMG_2hB MSH3 protein_coding   8.795604 3.082455 13.24025 0.2865308 0.56253 2.099195 1.657127 0.0000000 5.413486 0.0000000 1.0614877 9.0830767 0.1507042 0.00000000 0.41593333 0.41593333 7.592211e-09 7.592211e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113318 E001 8.6041121 0.0163248929 5.079377e-02 1.105908e-01 5 80654652 80654693 42 + 0.977 0.683 -1.153
ENSG00000113318 E002 33.1678432 0.0041559863 5.049076e-05 2.842677e-04 5 80654694 80654964 271 + 1.529 1.177 -1.225
ENSG00000113318 E003 0.8868421 0.0254836675 8.036310e-01 8.750294e-01 5 80655152 80655262 111 + 0.263 0.214 -0.386
ENSG00000113318 E004 2.0659922 0.0067502673 5.216954e-01 6.555867e-01 5 80655263 80655579 317 + 0.476 0.357 -0.648
ENSG00000113318 E005 34.0679894 0.0006031695 6.515331e-03 1.996135e-02 5 80656411 80656531 121 + 1.517 1.317 -0.693
ENSG00000113318 E006 59.8178949 0.0003887868 1.043167e-02 2.982116e-02 5 80665143 80665363 221 + 1.745 1.607 -0.465
ENSG00000113318 E007 66.2791201 0.0004233709 1.031345e-05 6.836673e-05 5 80670097 80670309 213 + 1.806 1.564 -0.821
ENSG00000113318 E008 47.9366494 0.0004590105 4.303526e-04 1.891304e-03 5 80672244 80672360 117 + 1.666 1.443 -0.763
ENSG00000113318 E009 66.4710062 0.0003796878 2.006215e-02 5.161629e-02 5 80672741 80672858 118 + 1.787 1.671 -0.392
ENSG00000113318 E010 67.3573835 0.0004142142 7.678033e-03 2.297226e-02 5 80674983 80675128 146 + 1.794 1.659 -0.456
ENSG00000113318 E011 56.2479072 0.0016790436 3.516569e-02 8.195997e-02 5 80678927 80679093 167 + 1.714 1.594 -0.406
ENSG00000113318 E012 0.0000000       5 80715205 80715393 189 +      
ENSG00000113318 E013 55.8791328 0.0009561667 1.097541e-03 4.295461e-03 5 80725453 80725565 113 + 1.725 1.533 -0.651
ENSG00000113318 E014 54.4860001 0.0006882036 1.859986e-03 6.789250e-03 5 80728851 80728965 115 + 1.715 1.533 -0.619
ENSG00000113318 E015 50.7889426 0.0008644595 1.178646e-02 3.302162e-02 5 80741464 80741548 85 + 1.682 1.533 -0.507
ENSG00000113318 E016 49.7833153 0.0004825822 2.831873e-02 6.863995e-02 5 80744506 80744615 110 + 1.668 1.541 -0.433
ENSG00000113318 E017 61.1299772 0.0004004380 3.579338e-01 5.023463e-01 5 80761546 80761678 133 + 1.735 1.694 -0.141
ENSG00000113318 E018 79.0551602 0.0003282316 1.865942e-01 3.094636e-01 5 80767933 80768120 188 + 1.848 1.793 -0.185
ENSG00000113318 E019 72.5998661 0.0004117188 1.420497e-01 2.508378e-01 5 80768835 80769003 169 + 1.816 1.751 -0.220
ENSG00000113318 E020 36.6299411 0.0109182741 3.607849e-01 5.051448e-01 5 80775694 80775758 65 + 1.488 1.571 0.284
ENSG00000113318 E021 50.3715735 0.0004598980 7.296243e-02 1.482673e-01 5 80778720 80778836 117 + 1.614 1.721 0.365
ENSG00000113318 E022 43.7921586 0.0005433018 1.833653e-01 3.054321e-01 5 80787565 80787672 108 + 1.559 1.647 0.298
ENSG00000113318 E023 51.9470721 0.0005218383 2.394761e-01 3.735083e-01 5 80792733 80792844 112 + 1.637 1.710 0.247
ENSG00000113318 E024 41.2232492 0.0005485532 2.461836e-01 3.814749e-01 5 80813584 80813624 41 + 1.535 1.614 0.272
ENSG00000113318 E025 60.8152939 0.0004528393 2.484477e-03 8.717690e-03 5 80813625 80813741 117 + 1.677 1.836 0.537
ENSG00000113318 E026 0.2214452 0.0383932512 1.155012e-01   5 80830637 80830740 104 + 0.000 0.215 10.333
ENSG00000113318 E027 1.0393871 0.0211156776 1.223971e-01 2.233674e-01 5 80848448 80848612 165 + 0.176 0.465 1.940
ENSG00000113318 E028 87.1395418 0.0046557854 3.890995e-04 1.732525e-03 5 80854130 80854316 187 + 1.822 2.009 0.632
ENSG00000113318 E029 74.9062302 0.0006086143 7.060102e-09 8.953777e-08 5 80864813 80864942 130 + 1.734 1.996 0.883
ENSG00000113318 E030 88.0379732 0.0003362893 7.560594e-09 9.528297e-08 5 80873116 80873287 172 + 1.811 2.051 0.808
ENSG00000113318 E031 69.9220476 0.0004076829 1.750693e-02 4.605798e-02 5 80875751 80875955 205 + 1.751 1.871 0.404
ENSG00000113318 E032 84.1068302 0.0067793070 4.211631e-04 1.855580e-03 5 80875956 80876815 860 + 1.805 2.013 0.698
ENSG00000113318 E033 0.0000000       5 80889570 80889596 27 +