ENSG00000113300

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261951 ENSG00000113300 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT6 protein_coding protein_coding 19.4796 9.607922 27.43168 1.177889 0.3083061 1.512572 8.6178577 2.179795 16.18271816 1.3628569 0.53839632 2.886478 0.40583750 0.2238667 0.590366667 0.36650000 3.596434e-01 1.006221e-13 FALSE TRUE
MSTRG.27466.13 ENSG00000113300 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT6 protein_coding   19.4796 9.607922 27.43168 1.177889 0.3083061 1.512572 0.8372292 1.624375 0.08696603 0.3122996 0.08696603 -4.075116 0.08435833 0.1662667 0.003233333 -0.16303333 2.653550e-04 1.006221e-13 FALSE TRUE
MSTRG.27466.3 ENSG00000113300 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT6 protein_coding   19.4796 9.607922 27.43168 1.177889 0.3083061 1.512572 1.2554413 2.713078 0.00000000 1.3737474 0.00000000 -8.089094 0.12769167 0.2813667 0.000000000 -0.28136667 8.727474e-02 1.006221e-13 FALSE TRUE
MSTRG.27466.4 ENSG00000113300 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT6 protein_coding   19.4796 9.607922 27.43168 1.177889 0.3083061 1.512572 2.0955995 0.000000 3.41599916 0.0000000 0.62343153 8.420381 0.07264583 0.0000000 0.124066667 0.12406667 1.006221e-13 1.006221e-13 FALSE FALSE
MSTRG.27466.8 ENSG00000113300 HEK293_OSMI2_2hA HEK293_TMG_2hB CNOT6 protein_coding   19.4796 9.607922 27.43168 1.177889 0.3083061 1.512572 4.6021004 2.299495 4.84792541 0.2229130 0.66894649 1.072763 0.21618750 0.2408000 0.177033333 -0.06376667 3.112132e-01 1.006221e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113300 E001 0.1817044 0.0420460107 1.882575e-01   5 180493936 180494340 405 + 0.000 0.204 10.551
ENSG00000113300 E002 0.3332198 0.0316633286 4.995576e-01   5 180494341 180494341 1 + 0.071 0.204 1.761
ENSG00000113300 E003 0.3332198 0.0316633286 4.995576e-01   5 180494342 180494352 11 + 0.071 0.204 1.761
ENSG00000113300 E004 1.2125613 0.0201625802 2.879371e-01 4.284758e-01 5 180494353 180494378 26 + 0.350 0.204 -1.046
ENSG00000113300 E005 1.2125613 0.0201625802 2.879371e-01 4.284758e-01 5 180494379 180494380 2 + 0.350 0.204 -1.046
ENSG00000113300 E006 4.9112042 0.0726168877 9.139299e-02 1.773062e-01 5 180494381 180494411 31 + 0.775 0.533 -1.036
ENSG00000113300 E007 5.5023904 0.0721629129 5.188410e-02 1.125173e-01 5 180494412 180494426 15 + 0.823 0.533 -1.229
ENSG00000113300 E008 5.6496394 0.0873444288 5.537676e-02 1.186371e-01 5 180494427 180494432 6 + 0.835 0.534 -1.271
ENSG00000113300 E009 6.2042939 0.0497213227 5.137671e-03 1.630264e-02 5 180494433 180494446 14 + 0.887 0.448 -1.895
ENSG00000113300 E010 9.1644911 0.0443645736 1.381957e-04 6.956307e-04 5 180494447 180494497 51 + 1.051 0.448 -2.506
ENSG00000113300 E011 5.9924006 0.0375113238 1.038636e-04 5.398555e-04 5 180494498 180494506 9 + 0.897 0.204 -3.521
ENSG00000113300 E012 18.3254729 0.0111881252 7.859118e-07 6.677219e-06 5 180494507 180494574 68 + 1.318 0.844 -1.727
ENSG00000113300 E013 47.5644700 0.0009345175 1.482069e-10 2.540936e-09 5 180494575 180494706 132 + 1.692 1.408 -0.975
ENSG00000113300 E014 49.8621301 0.0004641378 2.440343e-07 2.299964e-06 5 180494707 180494763 57 + 1.692 1.515 -0.604
ENSG00000113300 E015 4.9707618 0.0230819419 6.448881e-01 7.571119e-01 5 180495421 180495514 94 + 0.673 0.846 0.696
ENSG00000113300 E016 4.1944492 0.0038285110 6.019419e-01 7.229845e-01 5 180495515 180495588 74 + 0.621 0.805 0.761
ENSG00000113300 E017 13.0856819 0.0013454297 1.933492e-01 3.179886e-01 5 180495652 180495755 104 + 1.103 1.093 -0.036
ENSG00000113300 E018 102.2672157 0.0008288697 1.812098e-18 9.664878e-17 5 180529275 180529388 114 + 2.016 1.749 -0.898
ENSG00000113300 E019 181.3635420 0.0008695275 2.145700e-12 4.985239e-11 5 180549931 180550117 187 + 2.233 2.130 -0.342
ENSG00000113300 E020 144.7756896 0.0002891542 7.600389e-13 1.902075e-11 5 180553386 180553471 86 + 2.138 2.022 -0.389
ENSG00000113300 E021 133.9241340 0.0003542568 2.635290e-11 5.123642e-10 5 180564489 180564578 90 + 2.103 1.994 -0.364
ENSG00000113300 E022 58.2685749 0.0016924852 2.095123e-06 1.622659e-05 5 180564579 180564593 15 + 1.755 1.614 -0.478
ENSG00000113300 E023 1.5081035 0.0454745604 5.553213e-01 6.842089e-01 5 180564594 180564674 81 + 0.383 0.342 -0.241
ENSG00000113300 E024 114.2065964 0.0002712422 3.516649e-09 4.709923e-08 5 180564675 180564743 69 + 2.034 1.941 -0.313
ENSG00000113300 E025 159.2720436 0.0002360173 1.249671e-08 1.513820e-07 5 180565820 180565977 158 + 2.165 2.115 -0.166
ENSG00000113300 E026 191.3916757 0.0002562348 1.273943e-11 2.607721e-10 5 180567088 180567242 155 + 2.247 2.178 -0.229
ENSG00000113300 E027 193.4345860 0.0045860331 8.926798e-04 3.588658e-03 5 180567849 180568003 155 + 2.240 2.222 -0.058
ENSG00000113300 E028 223.8918188 0.0002175384 2.532294e-09 3.484424e-08 5 180569110 180569340 231 + 2.306 2.279 -0.091
ENSG00000113300 E029 166.9540237 0.0002066196 2.436368e-10 4.020930e-09 5 180571230 180571432 203 + 2.190 2.125 -0.218
ENSG00000113300 E030 232.3781694 0.0011878026 2.323255e-09 3.218771e-08 5 180573988 180574269 282 + 2.328 2.276 -0.176
ENSG00000113300 E031 1266.5303609 0.0027287810 4.472432e-19 2.568320e-17 5 180574270 180576557 2288 + 2.950 3.246 0.985
ENSG00000113300 E032 508.7027346 0.0055155785 4.141676e-20 2.666988e-18 5 180576558 180578358 1801 + 2.483 2.936 1.507