ENSG00000113282

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000523908 ENSG00000113282 HEK293_OSMI2_2hA HEK293_TMG_2hB CLINT1 protein_coding protein_coding 41.34986 12.77392 71.13806 0.9724841 1.493555 2.476494 15.981343 0.0000000 29.475386 0.00000000 0.4416034 11.525784 0.26768333 0.00000000 0.41460000 0.41460000 5.039277e-78 5.039277e-78 FALSE TRUE
ENST00000524306 ENSG00000113282 HEK293_OSMI2_2hA HEK293_TMG_2hB CLINT1 protein_coding retained_intron 41.34986 12.77392 71.13806 0.9724841 1.493555 2.476494 1.780522 0.4096217 3.329916 0.06381849 0.1953008 2.992651 0.05537083 0.03170000 0.04676667 0.01506667 2.691619e-01 5.039277e-78 FALSE TRUE
ENST00000530302 ENSG00000113282 HEK293_OSMI2_2hA HEK293_TMG_2hB CLINT1 protein_coding retained_intron 41.34986 12.77392 71.13806 0.9724841 1.493555 2.476494 3.874062 0.6701517 8.050788 0.33965786 0.6488185 3.566992 0.07817500 0.05216667 0.11306667 0.06090000 5.341963e-01 5.039277e-78 FALSE FALSE
ENST00000530742 ENSG00000113282 HEK293_OSMI2_2hA HEK293_TMG_2hB CLINT1 protein_coding protein_coding 41.34986 12.77392 71.13806 0.9724841 1.493555 2.476494 2.649151 5.2313721 2.134926 0.64638055 0.3231483 -1.289016 0.16417917 0.40673333 0.02986667 -0.37686667 5.495818e-37 5.039277e-78 FALSE TRUE
MSTRG.27240.3 ENSG00000113282 HEK293_OSMI2_2hA HEK293_TMG_2hB CLINT1 protein_coding   41.34986 12.77392 71.13806 0.9724841 1.493555 2.476494 15.299179 5.2942005 25.693596 0.11765657 0.9751168 2.276763 0.38417500 0.41830000 0.36120000 -0.05710000 4.236726e-01 5.039277e-78 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113282 E001 0.1515154 0.0433040667 1.000000e+00   5 157785743 157785746 4 - 0.061 0.000 -8.956
ENSG00000113282 E002 1.5071705 0.0095173683 8.176660e-02 1.623276e-01 5 157785747 157786286 540 - 0.245 0.580 1.890
ENSG00000113282 E003 0.5514428 0.0199189683 2.972269e-03 1.018039e-02 5 157786287 157786290 4 - 0.000 0.492 14.671
ENSG00000113282 E004 656.0696715 0.0022420907 1.002326e-42 4.057429e-40 5 157786291 157787404 1114 - 2.623 2.988 1.214
ENSG00000113282 E005 173.4599645 0.0035416191 3.601045e-04 1.619367e-03 5 157787405 157787470 66 - 2.109 2.287 0.596
ENSG00000113282 E006 212.5949973 0.0006219988 1.136499e-06 9.325057e-06 5 157787471 157787601 131 - 2.197 2.372 0.584
ENSG00000113282 E007 152.5646564 0.0012282906 1.647568e-02 4.378724e-02 5 157787602 157787659 58 - 2.069 2.188 0.397
ENSG00000113282 E008 480.7164006 0.0004414855 1.841934e-01 3.064934e-01 5 157787660 157787992 333 - 2.579 2.637 0.192
ENSG00000113282 E009 3.6233368 0.0427777356 6.965636e-02 1.427912e-01 5 157787993 157788018 26 - 0.514 0.858 1.452
ENSG00000113282 E010 285.6247474 0.0001857681 3.385432e-01 4.824178e-01 5 157789363 157789513 151 - 2.355 2.409 0.182
ENSG00000113282 E011 60.6277033 0.0004083829 7.142570e-01 8.105207e-01 5 157789514 157789567 54 - 1.690 1.740 0.169
ENSG00000113282 E012 45.7502842 0.0005080801 9.552374e-05 5.010018e-04 5 157789568 157790561 994 - 1.623 1.369 -0.872
ENSG00000113282 E013 13.3818871 0.0056596568 1.265816e-02 3.510651e-02 5 157790600 157790651 52 - 1.122 0.819 -1.131
ENSG00000113282 E014 14.2719765 0.0045199614 3.200771e-02 7.587199e-02 5 157791620 157791702 83 - 1.142 0.903 -0.879
ENSG00000113282 E015 162.2698775 0.0002456498 3.021659e-01 4.440237e-01 5 157791703 157791757 55 - 2.124 2.118 -0.020
ENSG00000113282 E016 342.6245669 0.0002296202 6.199396e-02 1.299753e-01 5 157791758 157791989 232 - 2.449 2.434 -0.050
ENSG00000113282 E017 111.7679891 0.0025054769 9.626459e-01 9.803983e-01 5 157791990 157791995 6 - 1.956 1.989 0.110
ENSG00000113282 E018 188.9795347 0.0002574854 1.132817e-02 3.194914e-02 5 157794898 157794972 75 - 2.199 2.145 -0.180
ENSG00000113282 E019 2.0871985 0.0343963441 3.607758e-02 8.373503e-02 5 157794973 157796145 1173 - 0.494 0.000 -12.748
ENSG00000113282 E020 186.7304448 0.0002935136 3.524945e-02 8.212487e-02 5 157803650 157803719 70 - 2.191 2.151 -0.133
ENSG00000113282 E021 385.4902819 0.0007138788 3.863361e-03 1.275824e-02 5 157805866 157806112 247 - 2.506 2.463 -0.142
ENSG00000113282 E022 338.1943313 0.0010076341 8.715741e-06 5.871039e-05 5 157809628 157809805 178 - 2.459 2.362 -0.324
ENSG00000113282 E023 350.3316552 0.0001474107 1.199564e-10 2.089883e-09 5 157813063 157813227 165 - 2.479 2.348 -0.435
ENSG00000113282 E024 260.4110559 0.0002083689 1.246790e-10 2.166183e-09 5 157814185 157814293 109 - 2.354 2.193 -0.538
ENSG00000113282 E025 238.3275013 0.0033467271 2.338130e-05 1.427081e-04 5 157816734 157816830 97 - 2.313 2.166 -0.490
ENSG00000113282 E026 197.1361354 0.0141205318 6.397381e-03 1.965561e-02 5 157817443 157817547 105 - 2.232 2.080 -0.509
ENSG00000113282 E027 100.1883937 0.0008295587 1.958904e-07 1.880364e-06 5 157858930 157858952 23 - 1.953 1.717 -0.794
ENSG00000113282 E028 130.3104491 0.0003026896 1.118007e-09 1.643030e-08 5 157858953 157859039 87 - 2.065 1.830 -0.793
ENSG00000113282 E029 89.3699456 0.0005838114 3.632920e-08 4.023652e-07 5 157859040 157859163 124 - 1.908 1.641 -0.902