ENSG00000113194

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261942 ENSG00000113194 HEK293_OSMI2_2hA HEK293_TMG_2hB FAF2 protein_coding protein_coding 52.44809 37.51305 65.31117 2.889725 0.4823807 0.7997734 41.266651 31.332446 48.928441 2.5367243 0.5951782 0.6428504 0.79365833 0.8347667 0.74930000 -0.08546667 0.015826076 8.966184e-05 FALSE  
MSTRG.27358.3 ENSG00000113194 HEK293_OSMI2_2hA HEK293_TMG_2hB FAF2 protein_coding   52.44809 37.51305 65.31117 2.889725 0.4823807 0.7997734 5.929904 4.676900 6.688527 0.7586833 0.4770625 0.5152100 0.11773333 0.1246000 0.10233333 -0.02226667 0.651323116 8.966184e-05 FALSE  
MSTRG.27358.4 ENSG00000113194 HEK293_OSMI2_2hA HEK293_TMG_2hB FAF2 protein_coding   52.44809 37.51305 65.31117 2.889725 0.4823807 0.7997734 2.576290 0.784728 5.433154 0.2147626 1.0484340 2.7759097 0.04419167 0.0214000 0.08306667 0.06166667 0.009953162 8.966184e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113194 E001 0.5890081 0.0220192836 6.753435e-01 7.806518e-01 5 176447445 176447627 183 + 0.159 0.291 1.108
ENSG00000113194 E002 3.1238369 0.0052347620 2.471464e-01 3.825694e-01 5 176447628 176448169 542 + 0.476 0.762 1.263
ENSG00000113194 E003 1.0479225 0.2859549100 6.203137e-02 1.300397e-01 5 176448315 176448320 6 + 0.408 0.000 -13.567
ENSG00000113194 E004 45.1446620 0.0008536282 1.845189e-04 8.972189e-04 5 176448321 176448384 64 + 1.666 1.599 -0.228
ENSG00000113194 E005 107.2570309 0.0041179810 4.529606e-05 2.579339e-04 5 176448385 176448428 44 + 2.034 1.980 -0.182
ENSG00000113194 E006 145.7736674 0.0070714859 9.810904e-05 5.131406e-04 5 176448429 176448470 42 + 2.169 2.108 -0.204
ENSG00000113194 E007 3.3009296 0.0721438126 7.439887e-02 1.505755e-01 5 176452240 176452362 123 + 0.698 0.461 -1.076
ENSG00000113194 E008 0.4396707 0.0271126712 1.789328e-01 2.998044e-01 5 176453097 176453138 42 + 0.221 0.000 -12.338
ENSG00000113194 E009 0.7437457 0.0153787590 3.614922e-01 5.058808e-01 5 176453139 176453175 37 + 0.275 0.170 -0.890
ENSG00000113194 E010 3.6204053 0.0044995440 7.740572e-02 1.552990e-01 5 176453176 176453228 53 + 0.698 0.531 -0.736
ENSG00000113194 E011 2.7323275 0.0056606360 2.652154e-01 4.032541e-01 5 176453318 176453702 385 + 0.443 0.724 1.280
ENSG00000113194 E012 207.6206119 0.0094957615 5.085867e-04 2.191777e-03 5 176479188 176479256 69 + 2.318 2.268 -0.167
ENSG00000113194 E013 300.7253271 0.0076045210 4.192727e-05 2.404928e-04 5 176486355 176486489 135 + 2.480 2.426 -0.180
ENSG00000113194 E014 225.4089660 0.0027317155 2.885609e-06 2.167090e-05 5 176488951 176489027 77 + 2.345 2.322 -0.078
ENSG00000113194 E015 170.6452458 0.0012532254 3.596148e-06 2.645437e-05 5 176492194 176492238 45 + 2.221 2.212 -0.027
ENSG00000113194 E016 232.3247677 0.0054369424 1.245221e-02 3.462395e-02 5 176492239 176492332 94 + 2.338 2.372 0.112
ENSG00000113194 E017 153.6904219 0.0023372249 1.957929e-03 7.094539e-03 5 176493999 176494021 23 + 2.163 2.189 0.088
ENSG00000113194 E018 234.6634273 0.0045256851 1.456809e-04 7.285468e-04 5 176494022 176494084 63 + 2.359 2.347 -0.040
ENSG00000113194 E019 0.2998086 0.0285316182 7.535993e-01   5 176494085 176494183 99 + 0.087 0.170 1.108
ENSG00000113194 E020 316.5101694 0.0069330810 5.272170e-06 3.732564e-05 5 176494184 176494275 92 + 2.506 2.443 -0.211
ENSG00000113194 E021 481.0014437 0.0022785411 7.095751e-11 1.283802e-09 5 176496486 176496663 178 + 2.680 2.639 -0.137
ENSG00000113194 E022 11.1332269 0.0024285124 3.330355e-05 1.958059e-04 5 176496664 176496986 323 + 1.162 0.829 -1.235
ENSG00000113194 E023 439.1464749 0.0001774661 5.668104e-19 3.214024e-17 5 176498914 176499085 172 + 2.632 2.617 -0.053
ENSG00000113194 E024 329.0997738 0.0003291415 4.621053e-05 2.625966e-04 5 176500003 176500146 144 + 2.480 2.538 0.192
ENSG00000113194 E025 4197.4448084 0.0100593946 3.274065e-08 3.660010e-07 5 176506768 176510074 3307 + 3.491 3.755 0.878