ENSG00000113163

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261415 ENSG00000113163 HEK293_OSMI2_2hA HEK293_TMG_2hB CERT1 protein_coding protein_coding 10.4404 2.845738 17.39249 0.0564944 0.8990167 2.607358 0.2176022 0.0000000 1.0381917 0.00000000 0.1501789 6.711759 0.01249583 0.00000000 0.05916667 0.05916667 0.0000548388 5.48388e-05 FALSE TRUE
ENST00000380494 ENSG00000113163 HEK293_OSMI2_2hA HEK293_TMG_2hB CERT1 protein_coding protein_coding 10.4404 2.845738 17.39249 0.0564944 0.8990167 2.607358 4.0088910 1.6093326 6.2756710 0.07237272 0.2958569 1.956667 0.45384583 0.56700000 0.36146667 -0.20553333 0.0008768745 5.48388e-05 FALSE TRUE
ENST00000642556 ENSG00000113163 HEK293_OSMI2_2hA HEK293_TMG_2hB CERT1 protein_coding protein_coding 10.4404 2.845738 17.39249 0.0564944 0.8990167 2.607358 1.5307202 0.3209230 3.1055318 0.18540315 0.4765344 3.234911 0.12728750 0.11090000 0.18233333 0.07143333 0.6528558842 5.48388e-05 FALSE TRUE
ENST00000643780 ENSG00000113163 HEK293_OSMI2_2hA HEK293_TMG_2hB CERT1 protein_coding protein_coding 10.4404 2.845738 17.39249 0.0564944 0.8990167 2.607358 0.5557141 0.2661585 0.6342225 0.07093510 0.0300293 1.222063 0.06907917 0.09403333 0.03676667 -0.05726667 0.0432114066 5.48388e-05 FALSE TRUE
ENST00000644445 ENSG00000113163 HEK293_OSMI2_2hA HEK293_TMG_2hB CERT1 protein_coding protein_coding 10.4404 2.845738 17.39249 0.0564944 0.8990167 2.607358 1.8711103 0.3309693 2.7429164 0.14651141 0.3338913 3.013247 0.16142917 0.11556667 0.15690000 0.04133333 0.6479921178 5.48388e-05 FALSE TRUE
ENST00000645483 ENSG00000113163 HEK293_OSMI2_2hA HEK293_TMG_2hB CERT1 protein_coding protein_coding 10.4404 2.845738 17.39249 0.0564944 0.8990167 2.607358 0.7595919 0.0000000 1.2508640 0.00000000 0.6839675 6.978269 0.04228333 0.00000000 0.07083333 0.07083333 0.4354587880 5.48388e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113163 E001 0.0000000       5 75356345 75356351 7 -      
ENSG00000113163 E002 0.4417591 0.0911495947 6.095226e-02 1.282384e-01 5 75356352 75357012 661 - 0.056 0.403 3.476
ENSG00000113163 E003 0.0000000       5 75368486 75368486 1 -      
ENSG00000113163 E004 0.0000000       5 75368487 75368487 1 -      
ENSG00000113163 E005 1.0725974 0.0138603539 1.563333e-02 4.191818e-02 5 75368488 75368517 30 - 0.150 0.610 2.901
ENSG00000113163 E006 3.9867179 0.0040444425 2.763081e-04 1.283267e-03 5 75368518 75368658 141 - 0.445 1.011 2.373
ENSG00000113163 E007 4.0692365 0.0791668508 1.079121e-01 2.024381e-01 5 75368659 75369236 578 - 0.541 0.890 1.453
ENSG00000113163 E008 17.3535564 0.0084960138 3.524974e-04 1.590141e-03 5 75369237 75371119 1883 - 1.058 1.446 1.366
ENSG00000113163 E009 4.5250264 0.0587478288 3.158327e-02 7.503769e-02 5 75371120 75371120 1 - 0.541 0.942 1.645
ENSG00000113163 E010 187.8336711 0.0136032611 7.269512e-08 7.582377e-07 5 75371121 75372330 1210 - 2.073 2.429 1.191
ENSG00000113163 E011 16.4188582 0.0029870637 3.893453e-03 1.284521e-02 5 75372331 75372418 88 - 1.053 1.369 1.119
ENSG00000113163 E012 16.1222839 0.0016204879 2.447866e-03 8.606602e-03 5 75372419 75372430 12 - 1.042 1.369 1.158
ENSG00000113163 E013 36.6004509 0.0005870556 6.407034e-06 4.451511e-05 5 75372431 75372597 167 - 1.384 1.715 1.133
ENSG00000113163 E014 156.5786222 0.0066132490 1.053352e-01 1.986019e-01 5 75372598 75373269 672 - 2.056 2.175 0.399
ENSG00000113163 E015 38.3355315 0.0240439072 2.349474e-01 3.682872e-01 5 75373270 75373362 93 - 1.446 1.603 0.536
ENSG00000113163 E016 90.9782830 0.0006342407 2.510969e-01 3.872543e-01 5 75373363 75373962 600 - 1.830 1.922 0.310
ENSG00000113163 E017 42.0262849 0.0020208302 6.649653e-01 7.726902e-01 5 75373963 75374154 192 - 1.511 1.579 0.233
ENSG00000113163 E018 20.0376037 0.0011474645 2.771880e-01 4.167024e-01 5 75374155 75374155 1 - 1.225 1.150 -0.268
ENSG00000113163 E019 28.1595188 0.0007127966 5.052736e-01 6.410738e-01 5 75374156 75374191 36 - 1.359 1.339 -0.069
ENSG00000113163 E020 12.7675778 0.0315789693 8.524243e-05 4.527947e-04 5 75377775 75378517 743 - 0.880 1.418 1.935
ENSG00000113163 E021 10.5502853 0.0015959986 4.554498e-07 4.060213e-06 5 75378518 75379336 819 - 0.784 1.354 2.088
ENSG00000113163 E022 22.7436819 0.0008491729 9.193744e-01 9.530602e-01 5 75379337 75379354 18 - 1.262 1.290 0.097
ENSG00000113163 E023 33.2532029 0.0007555024 6.543968e-01 7.645763e-01 5 75379355 75379399 45 - 1.410 1.481 0.246
ENSG00000113163 E024 23.6574162 0.0022625485 6.057963e-01 7.261136e-01 5 75379400 75379418 19 - 1.285 1.273 -0.042
ENSG00000113163 E025 37.3152501 0.0057210069 4.741236e-02 1.045674e-01 5 75379419 75379459 41 - 1.492 1.354 -0.477
ENSG00000113163 E026 33.1936343 0.0023897072 3.053045e-02 7.301155e-02 5 75379460 75379473 14 - 1.444 1.290 -0.532
ENSG00000113163 E027 52.4764014 0.0071506333 1.232199e-01 2.245643e-01 5 75381072 75381144 73 - 1.628 1.543 -0.287
ENSG00000113163 E028 51.8639709 0.0055498955 5.874521e-01 7.107389e-01 5 75381145 75381201 57 - 1.609 1.606 -0.012
ENSG00000113163 E029 62.1694594 0.0016979506 9.957761e-01 1.000000e+00 5 75381949 75382077 129 - 1.678 1.715 0.126
ENSG00000113163 E030 44.2062627 0.0038701899 2.716576e-01 4.104322e-01 5 75384642 75384712 71 - 1.550 1.503 -0.159
ENSG00000113163 E031 42.3789812 0.0112105792 2.693696e-01 4.078896e-01 5 75385902 75385947 46 - 1.534 1.471 -0.216
ENSG00000113163 E032 50.2840333 0.0059562545 1.502033e-01 2.619518e-01 5 75385948 75386034 87 - 1.608 1.534 -0.251
ENSG00000113163 E033 0.0000000       5 75386035 75386057 23 -      
ENSG00000113163 E034 57.4589113 0.0050479931 7.889559e-01 8.648947e-01 5 75389592 75389687 96 - 1.648 1.668 0.065
ENSG00000113163 E035 17.9836405 0.0009893423 2.883903e-02 6.968354e-02 5 75399310 75399387 78 - 1.196 0.977 -0.792
ENSG00000113163 E036 54.6071087 0.0016004252 3.143583e-01 4.570724e-01 5 75400205 75400291 87 - 1.634 1.606 -0.094
ENSG00000113163 E037 29.8744791 0.0073822600 3.672842e-01 5.116506e-01 5 75400292 75400297 6 - 1.386 1.339 -0.165
ENSG00000113163 E038 0.3686942 0.0299861472 2.343662e-01 3.676072e-01 5 75400298 75402674 2377 - 0.056 0.249 2.493
ENSG00000113163 E039 0.0000000       5 75402675 75402792 118 -      
ENSG00000113163 E040 0.1451727 0.0426895098 1.000000e+00   5 75402793 75402971 179 - 0.056 0.001 -6.494
ENSG00000113163 E041 53.6637567 0.0022223278 1.694058e-02 4.479819e-02 5 75402972 75403058 87 - 1.643 1.514 -0.442
ENSG00000113163 E042 0.4407149 0.0213193143 4.434791e-01 5.850606e-01 5 75410690 75411010 321 - 0.105 0.248 1.488
ENSG00000113163 E043 60.9134449 0.0017427348 3.204298e-02 7.593754e-02 5 75411011 75411103 93 - 1.691 1.589 -0.345
ENSG00000113163 E044 68.7650280 0.0016614120 8.981247e-03 2.623337e-02 5 75416876 75417010 135 - 1.746 1.622 -0.421
ENSG00000113163 E045 38.3287690 0.0005368584 3.068728e-03 1.046893e-02 5 75417011 75417033 23 - 1.511 1.307 -0.706
ENSG00000113163 E046 53.1259756 0.0004008651 5.857610e-04 2.481122e-03 5 75419341 75419424 84 - 1.649 1.447 -0.689
ENSG00000113163 E047 0.0000000       5 75425270 75425291 22 -      
ENSG00000113163 E048 0.0000000       5 75425292 75425360 69 -      
ENSG00000113163 E049 72.6749585 0.0003643722 2.382499e-06 1.822708e-05 5 75425361 75425494 134 - 1.786 1.534 -0.859
ENSG00000113163 E050 38.1288160 0.0005496552 2.078499e-03 7.467293e-03 5 75425495 75425499 5 - 1.507 1.290 -0.751
ENSG00000113163 E051 63.0645997 0.0005247168 1.717791e-03 6.338111e-03 5 75426371 75426478 108 - 1.713 1.553 -0.545
ENSG00000113163 E052 57.0331795 0.0004704898 1.007169e-03 3.983323e-03 5 75459065 75459181 117 - 1.675 1.493 -0.621
ENSG00000113163 E053 0.0000000       5 75505230 75505981 752 -      
ENSG00000113163 E054 55.0900688 0.0004346672 2.735446e-03 9.479817e-03 5 75505982 75506116 135 - 1.657 1.493 -0.560
ENSG00000113163 E055 57.7606498 0.0006150229 1.371323e-03 5.212961e-03 5 75511112 75511428 317 - 1.678 1.503 -0.597
ENSG00000113163 E056 28.0030443 0.0428760515 4.282059e-01 5.709985e-01 5 75511429 75511505 77 - 1.361 1.305 -0.194
ENSG00000113163 E057 25.0933108 0.0009006728 6.901634e-01 7.919261e-01 5 75511506 75511638 133 - 1.306 1.307 0.004
ENSG00000113163 E058 0.6028395 0.4784816084 6.139326e-01 7.325176e-01 5 75511759 75512138 380 - 0.151 0.244 0.858