ENSG00000113119

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394671 ENSG00000113119 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO6 protein_coding protein_coding 16.50232 16.53818 11.83686 1.37852 0.2974571 -0.4821675 1.487141 4.4608362 0.8565967 0.4467976 0.61305108 -2.36711197 0.09513333 0.27770000 0.07230000 -0.20540000 0.26380867 0.02786905 FALSE  
ENST00000509269 ENSG00000113119 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO6 protein_coding retained_intron 16.50232 16.53818 11.83686 1.37852 0.2974571 -0.4821675 1.814831 1.0164958 1.5420947 0.1194296 0.07749509 0.59648883 0.11095417 0.06330000 0.13080000 0.06750000 0.02786905 0.02786905    
ENST00000510336 ENSG00000113119 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO6 protein_coding retained_intron 16.50232 16.53818 11.83686 1.37852 0.2974571 -0.4821675 1.699579 1.4358696 1.3473308 0.2113895 0.27341045 -0.09116502 0.10152083 0.08583333 0.11496667 0.02913333 0.69215847 0.02786905 FALSE  
ENST00000511410 ENSG00000113119 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO6 protein_coding retained_intron 16.50232 16.53818 11.83686 1.37852 0.2974571 -0.4821675 2.022758 1.3432900 1.6500262 0.1003480 0.10478647 0.29473502 0.12083750 0.08223333 0.13960000 0.05736667 0.03957040 0.02786905 FALSE  
ENST00000515265 ENSG00000113119 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO6 protein_coding retained_intron 16.50232 16.53818 11.83686 1.37852 0.2974571 -0.4821675 2.279900 1.8150593 1.8499307 0.2106386 0.10766501 0.02730550 0.13828333 0.11226667 0.15650000 0.04423333 0.39309787 0.02786905 FALSE  
ENST00000515653 ENSG00000113119 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO6 protein_coding nonsense_mediated_decay 16.50232 16.53818 11.83686 1.37852 0.2974571 -0.4821675 1.357510 1.2974736 0.8856942 0.3448943 0.22304072 -0.54570361 0.08060000 0.07603333 0.07403333 -0.00200000 0.99955443 0.02786905 TRUE  
MSTRG.27039.12 ENSG00000113119 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO6 protein_coding   16.50232 16.53818 11.83686 1.37852 0.2974571 -0.4821675 1.224800 1.7284159 0.6486338 0.4704763 0.18890663 -1.40022487 0.07503333 0.10146667 0.05490000 -0.04656667 0.35952898 0.02786905 FALSE  
MSTRG.27039.16 ENSG00000113119 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO6 protein_coding   16.50232 16.53818 11.83686 1.37852 0.2974571 -0.4821675 1.417390 0.4033541 0.8332457 0.1512664 0.12118198 1.02857492 0.08381250 0.02416667 0.07036667 0.04620000 0.04163330 0.02786905 FALSE  
MSTRG.27039.7 ENSG00000113119 HEK293_OSMI2_2hA HEK293_TMG_2hB TMCO6 protein_coding   16.50232 16.53818 11.83686 1.37852 0.2974571 -0.4821675 1.006676 0.8591099 0.8375005 0.4521893 0.45466266 -0.03632438 0.06709583 0.04796667 0.06890000 0.02093333 0.97159967 0.02786905 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113119 E001 0.0000000       5 140639404 140639434 31 +      
ENSG00000113119 E002 0.7675920 0.0162119016 2.554156e-01 0.3923021701 5 140639435 140639447 13 + 0.370 0.168 -1.505
ENSG00000113119 E003 0.9127647 0.0744902528 1.383223e-01 0.2457724729 5 140639448 140639450 3 + 0.445 0.168 -1.922
ENSG00000113119 E004 1.2125733 0.0145571861 1.157067e-01 0.2138251366 5 140639451 140639452 2 + 0.510 0.233 -1.658
ENSG00000113119 E005 2.8334904 0.0058283047 6.481821e-01 0.7597456032 5 140639453 140639462 10 + 0.510 0.584 0.343
ENSG00000113119 E006 4.5736456 0.0036767207 8.826902e-01 0.9289238076 5 140639463 140639468 6 + 0.701 0.721 0.081
ENSG00000113119 E007 8.5404402 0.0023417136 9.165587e-01 0.9512581030 5 140639469 140639489 21 + 0.935 0.945 0.038
ENSG00000113119 E008 8.5435607 0.0021580882 6.887007e-01 0.7907746895 5 140639490 140639490 1 + 0.912 0.957 0.169
ENSG00000113119 E009 9.8647709 0.0019162106 4.378202e-01 0.5797032699 5 140639491 140639494 4 + 0.935 1.020 0.316
ENSG00000113119 E010 10.9374675 0.0016834968 3.034155e-01 0.4453222235 5 140639495 140639503 9 + 0.957 1.067 0.403
ENSG00000113119 E011 21.3212521 0.0009488382 6.089244e-01 0.7285104582 5 140639504 140639563 60 + 1.277 1.315 0.135
ENSG00000113119 E012 20.2590403 0.0012379471 7.014726e-01 0.8006340365 5 140639564 140639608 45 + 1.306 1.273 -0.115
ENSG00000113119 E013 11.6338450 0.0016441329 8.770284e-01 0.9250278231 5 140639609 140639612 4 + 1.053 1.066 0.050
ENSG00000113119 E014 0.8438645 0.0143084448 8.079793e-01 0.8779821896 5 140639613 140639738 126 + 0.278 0.233 -0.334
ENSG00000113119 E015 45.4425798 0.0132334275 9.650071e-01 0.9819669774 5 140639739 140639851 113 + 1.630 1.627 -0.010
ENSG00000113119 E016 4.2417869 0.1910066319 4.373852e-01 0.5793485152 5 140639852 140639864 13 + 0.774 0.628 -0.605
ENSG00000113119 E017 3.0518057 0.0054178001 1.306592e-02 0.0360643315 5 140640651 140640777 127 + 0.804 0.424 -1.696
ENSG00000113119 E018 3.3067758 0.0111644144 2.610101e-02 0.0641501612 5 140640778 140640838 61 + 0.804 0.462 -1.501
ENSG00000113119 E019 4.9404722 0.0033429350 5.113836e-05 0.0002874951 5 140640839 140641017 179 + 1.035 0.496 -2.208
ENSG00000113119 E020 7.5598010 0.0022369353 7.120634e-02 0.1453425946 5 140641018 140641220 203 + 1.035 0.825 -0.794
ENSG00000113119 E021 4.2436612 0.0038112783 8.940698e-01 0.9362678653 5 140641221 140641244 24 + 0.701 0.680 -0.089
ENSG00000113119 E022 15.8103904 0.0190177295 3.624965e-02 0.0840602974 5 140641306 140641664 359 + 1.325 1.104 -0.782
ENSG00000113119 E023 56.5871563 0.0015373027 5.561185e-01 0.6848436738 5 140641665 140641780 116 + 1.697 1.726 0.098
ENSG00000113119 E024 10.8812107 0.0015877804 2.312417e-02 0.0580069933 5 140641781 140641869 89 + 1.185 0.956 -0.832
ENSG00000113119 E025 30.0403566 0.0006947175 9.718597e-01 0.9864324353 5 140641870 140641897 28 + 1.459 1.454 -0.015
ENSG00000113119 E026 54.3572562 0.0019583697 4.856853e-01 0.6235412718 5 140641898 140642053 156 + 1.677 1.714 0.124
ENSG00000113119 E027 20.5339419 0.0022141258 3.070297e-03 0.0104733531 5 140642054 140642314 261 + 1.445 1.214 -0.804
ENSG00000113119 E028 63.3672527 0.0004541565 8.177847e-02 0.1623471072 5 140642315 140642419 105 + 1.712 1.793 0.272
ENSG00000113119 E029 16.4186581 0.0049633841 3.563019e-01 0.5006879067 5 140642491 140642571 81 + 1.255 1.170 -0.304
ENSG00000113119 E030 11.7899571 0.0084450038 3.524070e-01 0.4966667602 5 140642572 140642585 14 + 1.131 1.031 -0.363
ENSG00000113119 E031 77.5152384 0.0003917990 6.954915e-01 0.7960696803 5 140642586 140642671 86 + 1.842 1.856 0.049
ENSG00000113119 E032 9.3373207 0.0075387626 4.546979e-02 0.1010560155 5 140642907 140642924 18 + 1.131 0.908 -0.823
ENSG00000113119 E033 91.7318457 0.0003639864 7.306644e-01 0.8225359925 5 140642925 140643041 117 + 1.916 1.927 0.038
ENSG00000113119 E034 9.8732471 0.0018183278 7.956666e-03 0.0236672334 5 140643363 140643563 201 + 1.172 0.896 -1.015
ENSG00000113119 E035 38.7239296 0.0007713236 8.377021e-01 0.8985502580 5 140643564 140643567 4 + 1.555 1.565 0.034
ENSG00000113119 E036 83.3321011 0.0003900323 6.022612e-01 0.7232471310 5 140643568 140643675 108 + 1.872 1.891 0.064
ENSG00000113119 E037 113.7130545 0.0003389331 2.975781e-01 0.4389420254 5 140643780 140643966 187 + 1.994 2.028 0.115
ENSG00000113119 E038 91.6998206 0.0003991920 9.228793e-01 0.9553606084 5 140644100 140644188 89 + 1.926 1.927 0.006
ENSG00000113119 E039 37.3740319 0.0006102571 3.930286e-01 0.5369121794 5 140644189 140644194 6 + 1.510 1.560 0.171
ENSG00000113119 E040 94.4426428 0.0015223114 5.129839e-02 0.1114653023 5 140644573 140644740 168 + 1.884 1.965 0.270
ENSG00000113119 E041 19.9470236 0.0186006549 2.149797e-02 0.0546399709 5 140644741 140644984 244 + 1.430 1.207 -0.780
ENSG00000113119 E042 129.5270600 0.0010907041 1.100812e-01 0.2056601536 5 140644985 140645408 424 + 2.039 2.093 0.183