ENSG00000113068

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261813 ENSG00000113068 HEK293_OSMI2_2hA HEK293_TMG_2hB PFDN1 protein_coding protein_coding 73.28763 93.09413 81.87771 5.470252 2.527459 -0.1851982 53.615322 75.54347 53.61590 4.061725 0.8529051 -0.4945681 0.7295250 0.8119667 0.6554000 -0.15656667 8.589924e-15 2.567404e-72 FALSE TRUE
ENST00000510217 ENSG00000113068 HEK293_OSMI2_2hA HEK293_TMG_2hB PFDN1 protein_coding protein_coding 73.28763 93.09413 81.87771 5.470252 2.527459 -0.1851982 9.961449 15.52990 9.63152 0.944265 0.5789610 -0.6886450 0.1408542 0.1669000 0.1177667 -0.04913333 5.553863e-03 2.567404e-72 FALSE TRUE
ENST00000524074 ENSG00000113068 HEK293_OSMI2_2hA HEK293_TMG_2hB PFDN1 protein_coding protein_coding 73.28763 93.09413 81.87771 5.470252 2.527459 -0.1851982 8.293418 0.00000 17.17388 0.000000 1.7746737 10.7468401 0.1110375 0.0000000 0.2088667 0.20886667 2.567404e-72 2.567404e-72 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000113068 E001 23.2828298 4.753188e-03 1.787659e-01 2.996053e-01 5 140245035 140245086 52 - 1.288 1.390 0.355
ENSG00000113068 E002 73.6146475 3.582207e-04 1.048590e-01 1.978786e-01 5 140245087 140245124 38 - 1.805 1.867 0.211
ENSG00000113068 E003 546.2178015 1.698335e-03 3.548071e-02 8.257836e-02 5 140245125 140245346 222 - 2.684 2.728 0.146
ENSG00000113068 E004 551.2870911 1.716951e-03 1.666888e-02 4.421201e-02 5 140245347 140245447 101 - 2.683 2.734 0.171
ENSG00000113068 E005 576.0058571 5.881059e-04 2.345859e-01 3.678543e-01 5 140245448 140245540 93 - 2.728 2.741 0.046
ENSG00000113068 E006 303.7132459 6.918535e-04 8.861814e-02 1.730125e-01 5 140245541 140245551 11 - 2.438 2.472 0.113
ENSG00000113068 E007 363.4014905 1.757038e-04 2.361492e-02 5.901690e-02 5 140245552 140245590 39 - 2.513 2.550 0.123
ENSG00000113068 E008 1403.0428628 8.207909e-05 8.675289e-03 2.547284e-02 5 140245591 140246054 464 - 3.112 3.128 0.054
ENSG00000113068 E009 341.2404774 2.356525e-04 6.460414e-01 7.580664e-01 5 140246055 140246057 3 - 2.521 2.503 -0.059
ENSG00000113068 E010 0.1472490 4.343689e-02 3.100125e-01   5 140262529 140262531 3 - 0.152 0.000 -10.687
ENSG00000113068 E011 0.1515154 4.334848e-02 3.098424e-01   5 140280960 140281444 485 - 0.152 0.000 -10.688
ENSG00000113068 E012 0.0000000       5 140281445 140281448 4 -      
ENSG00000113068 E013 627.9760762 9.840551e-04 2.067673e-01 3.346813e-01 5 140281449 140281533 85 - 2.795 2.760 -0.115
ENSG00000113068 E014 0.0000000       5 140281534 140281535 2 -      
ENSG00000113068 E015 0.0000000       5 140292899 140293207 309 -      
ENSG00000113068 E016 697.6867442 1.816283e-03 5.216388e-06 3.695972e-05 5 140300416 140300582 167 - 2.891 2.776 -0.380
ENSG00000113068 E017 1.7597627 6.011914e-02 6.563586e-01 7.659727e-01 5 140300583 140300583 1 - 0.490 0.400 -0.467
ENSG00000113068 E018 402.6750030 2.598803e-03 1.996842e-04 9.623886e-04 5 140303041 140303113 73 - 2.656 2.535 -0.401