ENSG00000112992

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264663 ENSG00000112992 HEK293_OSMI2_2hA HEK293_TMG_2hB NNT protein_coding protein_coding 17.0646 7.528519 25.46481 0.3509297 1.302042 1.756718 6.626015 2.7733911 9.388721 0.6120861 0.2108907 1.7556209 0.41409167 0.3680333 0.37156667 0.003533333 9.976904e-01 7.069227e-07 FALSE  
ENST00000344920 ENSG00000112992 HEK293_OSMI2_2hA HEK293_TMG_2hB NNT protein_coding protein_coding 17.0646 7.528519 25.46481 0.3509297 1.302042 1.756718 5.154301 3.4473771 6.040111 0.6980981 0.3910545 0.8072837 0.33483750 0.4555333 0.23686667 -0.218666667 5.266100e-02 7.069227e-07 FALSE  
ENST00000505678 ENSG00000112992 HEK293_OSMI2_2hA HEK293_TMG_2hB NNT protein_coding protein_coding 17.0646 7.528519 25.46481 0.3509297 1.302042 1.756718 1.102917 0.0000000 1.831580 0.0000000 0.4107744 7.5248002 0.03990417 0.0000000 0.07406667 0.074066667 7.069227e-07 7.069227e-07 FALSE  
ENST00000512422 ENSG00000112992 HEK293_OSMI2_2hA HEK293_TMG_2hB NNT protein_coding protein_coding 17.0646 7.528519 25.46481 0.3509297 1.302042 1.756718 2.800555 0.4796127 5.995140 0.2770309 1.6038353 3.6164849 0.11155000 0.0645000 0.22993333 0.165433333 3.427292e-01 7.069227e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112992 E001 3.3174631 0.1155710594 1.999748e-01 3.262202e-01 5 43602577 43602691 115 + 0.677 0.408 -1.268
ENSG00000112992 E002 5.6823215 0.0151142227 2.272056e-03 8.065699e-03 5 43602692 43602704 13 + 0.908 0.403 -2.216
ENSG00000112992 E003 13.9550185 0.0625686390 7.263958e-02 1.477380e-01 5 43602705 43602722 18 + 1.216 0.946 -0.979
ENSG00000112992 E004 27.0676278 0.0112344507 2.585180e-02 6.363508e-02 5 43602723 43602749 27 + 1.474 1.286 -0.651
ENSG00000112992 E005 25.3575598 0.0016336590 5.667376e-03 1.773309e-02 5 43602750 43602753 4 + 1.452 1.249 -0.707
ENSG00000112992 E006 46.1522689 0.0140040316 1.038047e-03 4.090329e-03 5 43602754 43602882 129 + 1.717 1.461 -0.873
ENSG00000112992 E007 25.5822067 0.0015070899 1.634377e-03 6.071253e-03 5 43602883 43602890 8 + 1.468 1.236 -0.807
ENSG00000112992 E008 0.4355181 0.6213630241 6.090073e-01 7.285820e-01 5 43602891 43602898 8 + 0.210 0.000 -11.831
ENSG00000112992 E009 2.1233634 0.1726822001 6.702183e-01 7.767174e-01 5 43602899 43603004 106 + 0.517 0.400 -0.595
ENSG00000112992 E010 2.2865201 0.0243851209 1.491495e-01 2.605120e-01 5 43603163 43603168 6 + 0.570 0.304 -1.418
ENSG00000112992 E011 3.6484187 0.0043419476 3.181047e-01 4.610476e-01 5 43603169 43603179 11 + 0.696 0.549 -0.645
ENSG00000112992 E012 4.1235890 0.0050928478 6.474954e-01 7.591567e-01 5 43603180 43603185 6 + 0.714 0.658 -0.234
ENSG00000112992 E013 4.7428878 0.0227950852 6.418165e-01 7.547639e-01 5 43603186 43603195 10 + 0.763 0.703 -0.245
ENSG00000112992 E014 6.3691972 0.0036208326 1.135043e-01 2.106346e-01 5 43603196 43603198 3 + 0.908 0.704 -0.806
ENSG00000112992 E015 8.7296954 0.0019052588 8.226210e-01 8.881669e-01 5 43603199 43603201 3 + 0.971 0.960 -0.040
ENSG00000112992 E016 8.7296954 0.0019052588 8.226210e-01 8.881669e-01 5 43603202 43603203 2 + 0.971 0.960 -0.040
ENSG00000112992 E017 29.6067863 0.0008269672 1.734517e-01 2.926792e-01 5 43603204 43603265 62 + 1.483 1.404 -0.273
ENSG00000112992 E018 29.8301915 0.0007108837 4.694804e-01 6.087171e-01 5 43603266 43603294 29 + 1.471 1.438 -0.115
ENSG00000112992 E019 0.1472490 0.0428631899 1.000000e+00   5 43603295 43603487 193 + 0.082 0.000 -11.504
ENSG00000112992 E020 0.4449813 0.0212582803 9.069312e-01 9.449232e-01 5 43603736 43603763 28 + 0.152 0.178 0.280
ENSG00000112992 E021 0.4449813 0.0212582803 9.069312e-01 9.449232e-01 5 43603779 43603840 62 + 0.152 0.178 0.280
ENSG00000112992 E022 0.5181333 0.0217681645 8.984192e-01 9.392107e-01 5 43604467 43604594 128 + 0.152 0.178 0.284
ENSG00000112992 E023 1.4394162 0.2103381043 3.201582e-01 4.632668e-01 5 43604595 43604670 76 + 0.264 0.493 1.337
ENSG00000112992 E024 140.6604304 0.0025687056 6.372310e-06 4.430147e-05 5 43609143 43609346 204 + 2.174 2.001 -0.582
ENSG00000112992 E025 0.2214452 0.0408945419 2.036972e-01   5 43609516 43609551 36 + 0.000 0.179 12.161
ENSG00000112992 E026 134.1672285 0.0015228850 5.365005e-06 3.791587e-05 5 43612908 43613090 183 + 2.152 1.991 -0.541
ENSG00000112992 E027 69.8481029 0.0012514109 1.956463e-03 7.090902e-03 5 43613091 43613137 47 + 1.867 1.730 -0.461
ENSG00000112992 E028 0.7469680 0.0178248854 1.236127e-01 2.251032e-01 5 43613138 43613481 344 + 0.310 0.000 -14.140
ENSG00000112992 E029 0.3030308 0.3622166149 6.688580e-01   5 43613482 43613650 169 + 0.152 0.000 -11.485
ENSG00000112992 E030 1.9961616 0.0073454321 2.271465e-01 3.589937e-01 5 43614500 43614619 120 + 0.518 0.304 -1.178
ENSG00000112992 E031 157.9909885 0.0003398867 1.169542e-08 1.424405e-07 5 43615848 43616065 218 + 2.225 2.057 -0.559
ENSG00000112992 E032 84.4457694 0.0051946961 1.128714e-02 3.184671e-02 5 43619032 43619086 55 + 1.944 1.817 -0.427
ENSG00000112992 E033 69.0377929 0.0059638830 2.936045e-02 7.069908e-02 5 43619087 43619119 33 + 1.856 1.739 -0.395
ENSG00000112992 E034 0.0000000       5 43623497 43623553 57 +      
ENSG00000112992 E035 107.4512452 0.0090352484 3.649116e-02 8.451609e-02 5 43624032 43624120 89 + 2.044 1.934 -0.371
ENSG00000112992 E036 126.9106893 0.0015883621 2.763446e-02 6.728096e-02 5 43628200 43628387 188 + 2.105 2.035 -0.233
ENSG00000112992 E037 100.2717937 0.0004677280 6.874057e-03 2.089683e-02 5 43644192 43644325 134 + 2.011 1.922 -0.298
ENSG00000112992 E038 114.2848035 0.0003086777 1.383910e-02 3.786067e-02 5 43644611 43644744 134 + 2.061 1.988 -0.242
ENSG00000112992 E039 92.3305856 0.0003250591 4.811656e-02 1.058359e-01 5 43644745 43644802 58 + 1.964 1.901 -0.210
ENSG00000112992 E040 159.9640623 0.0002285139 6.675443e-03 2.038004e-02 5 43645357 43645510 154 + 2.202 2.137 -0.220
ENSG00000112992 E041 0.3268771 0.0293068283 5.312525e-01   5 43645511 43645665 155 + 0.082 0.178 1.283
ENSG00000112992 E042 0.5911862 0.0184341118 1.952740e-01 3.203144e-01 5 43646484 43647923 1440 + 0.264 0.000 -13.818
ENSG00000112992 E043 1.7672263 0.0104437670 8.511733e-01 9.077188e-01 5 43647924 43648182 259 + 0.426 0.402 -0.132
ENSG00000112992 E044 0.6299079 0.0233656532 8.474299e-01 9.052585e-01 5 43648183 43648440 258 + 0.211 0.178 -0.303
ENSG00000112992 E045 1.2220365 0.0113127781 2.465188e-01 3.818788e-01 5 43648441 43649146 706 + 0.264 0.481 1.279
ENSG00000112992 E046 165.6635823 0.0002383787 6.601440e-07 5.701495e-06 5 43649147 43649308 162 + 2.238 2.103 -0.453
ENSG00000112992 E047 120.0565221 0.0009283043 4.465049e-05 2.545860e-04 5 43650477 43650587 111 + 2.101 1.962 -0.465
ENSG00000112992 E048 78.8087183 0.0030488379 1.629517e-03 6.055694e-03 5 43651739 43651783 45 + 1.922 1.776 -0.492
ENSG00000112992 E049 108.1154440 0.0003446135 2.838268e-04 1.314095e-03 5 43651784 43651884 101 + 2.051 1.930 -0.404
ENSG00000112992 E050 140.2729765 0.0004290761 2.469792e-02 6.125960e-02 5 43653018 43653213 196 + 2.143 2.085 -0.194
ENSG00000112992 E051 11.4660382 0.0035551673 9.593325e-01 9.784894e-01 5 43653214 43654560 1347 + 1.074 1.085 0.039
ENSG00000112992 E052 151.7388677 0.0003433429 9.258102e-02 1.791542e-01 5 43655840 43656073 234 + 2.134 2.202 0.227
ENSG00000112992 E053 146.0646734 0.0002321759 5.443693e-01 6.748582e-01 5 43656653 43656813 161 + 2.132 2.168 0.120
ENSG00000112992 E054 182.2855719 0.0006929191 4.941235e-01 6.311113e-01 5 43659171 43659350 180 + 2.228 2.267 0.127
ENSG00000112992 E055 197.1845516 0.0030166428 3.357905e-02 7.892772e-02 5 43675511 43675670 160 + 2.240 2.336 0.319
ENSG00000112992 E056 105.9941116 0.0029906930 8.406221e-04 3.403940e-03 5 43677725 43677778 54 + 1.947 2.109 0.545
ENSG00000112992 E057 76.1074548 0.0017078057 4.106362e-05 2.361036e-04 5 43677779 43677806 28 + 1.789 1.992 0.681
ENSG00000112992 E058 134.1020978 0.0007797064 1.770103e-07 1.713983e-06 5 43700119 43700237 119 + 2.037 2.228 0.639
ENSG00000112992 E059 148.9142934 0.0002277697 6.469623e-08 6.817503e-07 5 43702621 43702736 116 + 2.086 2.264 0.595
ENSG00000112992 E060 631.3677288 0.0011917614 1.355034e-40 4.889659e-38 5 43704255 43707405 3151 + 2.666 2.940 0.913