ENSG00000112984

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394894 ENSG00000112984 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF20A protein_coding protein_coding 36.53994 33.86575 35.39161 3.026602 1.096248 0.06356191 31.173759 28.2919229 28.687145 1.95532650 0.4361369 0.02000714 0.85086667 0.83993333 0.81183333 -0.02810000 7.925940e-01 1.391592e-12 FALSE TRUE
ENST00000502338 ENSG00000112984 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF20A protein_coding nonsense_mediated_decay 36.53994 33.86575 35.39161 3.026602 1.096248 0.06356191 1.760183 4.4415695 0.000000 1.82174495 0.0000000 -8.79817026 0.05061667 0.12453333 0.00000000 -0.12453333 1.391592e-12 1.391592e-12 FALSE TRUE
ENST00000503417 ENSG00000112984 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF20A protein_coding retained_intron 36.53994 33.86575 35.39161 3.026602 1.096248 0.06356191 1.458771 0.3424168 2.944426 0.08409996 0.6209035 3.06752334 0.04054167 0.01076667 0.08243333 0.07166667 1.893423e-05 1.391592e-12 FALSE TRUE
MSTRG.26992.2 ENSG00000112984 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF20A protein_coding   36.53994 33.86575 35.39161 3.026602 1.096248 0.06356191 1.984131 0.7472548 3.366200 0.24223069 0.3301537 2.15654949 0.05345417 0.02366667 0.09470000 0.07103333 2.879798e-03 1.391592e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112984 E001 1.3232761 0.0766749953 4.876635e-01 6.253055e-01 5 138178719 138178850 132 + 0.424 0.293 -0.779
ENSG00000112984 E002 3.9052195 0.0276961344 9.323359e-01 9.613677e-01 5 138179079 138179111 33 + 0.667 0.686 0.082
ENSG00000112984 E003 45.5531836 0.0036995988 9.891146e-01 9.972581e-01 5 138179112 138179159 48 + 1.660 1.672 0.040
ENSG00000112984 E004 55.1818080 0.0005077934 9.020359e-01 9.415887e-01 5 138179160 138179167 8 + 1.748 1.755 0.023
ENSG00000112984 E005 57.1725068 0.0029728425 9.103733e-01 9.470192e-01 5 138179168 138179168 1 + 1.763 1.771 0.024
ENSG00000112984 E006 107.0000576 0.0033686486 5.180310e-01 6.523232e-01 5 138179169 138179202 34 + 2.043 2.027 -0.052
ENSG00000112984 E007 0.7490443 0.0784843745 1.957404e-02 5.057131e-02 5 138179203 138179220 18 + 0.425 0.000 -12.098
ENSG00000112984 E008 0.8984834 0.0815309444 1.019396e-02 2.924356e-02 5 138179221 138179333 113 + 0.476 0.000 -12.361
ENSG00000112984 E009 2.4118975 0.0063855755 7.266060e-03 2.191618e-02 5 138179334 138179659 326 + 0.725 0.292 -2.169
ENSG00000112984 E010 232.2131792 0.0008692145 3.252801e-04 1.482078e-03 5 138179660 138179845 186 + 2.412 2.329 -0.278
ENSG00000112984 E011 140.7068115 0.0002561625 6.581632e-04 2.745262e-03 5 138181422 138181448 27 + 2.201 2.112 -0.297
ENSG00000112984 E012 167.7253017 0.0002100244 3.643451e-04 1.636031e-03 5 138181449 138181502 54 + 2.272 2.188 -0.283
ENSG00000112984 E013 112.9647069 0.0028512715 5.937532e-03 1.844436e-02 5 138181503 138181511 9 + 2.111 2.007 -0.349
ENSG00000112984 E014 232.6441720 0.0002337529 4.657992e-08 5.056109e-07 5 138181609 138181728 120 + 2.429 2.313 -0.387
ENSG00000112984 E015 8.8361519 0.0452769157 1.046898e-05 6.928858e-05 5 138181729 138181896 168 + 1.237 0.554 -2.659
ENSG00000112984 E016 257.4484983 0.0017848748 5.313898e-04 2.276988e-03 5 138182323 138182461 139 + 2.459 2.367 -0.307
ENSG00000112984 E017 279.0560901 0.0021678801 5.517915e-02 1.183007e-01 5 138182586 138182773 188 + 2.472 2.423 -0.161
ENSG00000112984 E018 221.8842691 0.0002087447 1.353981e-04 6.829458e-04 5 138182861 138182990 130 + 2.390 2.311 -0.263
ENSG00000112984 E019 281.0391520 0.0004450145 7.526949e-04 3.089164e-03 5 138183169 138183363 195 + 2.485 2.421 -0.212
ENSG00000112984 E020 223.7098280 0.0001962015 5.220290e-02 1.130754e-01 5 138183470 138183581 112 + 2.370 2.337 -0.112
ENSG00000112984 E021 202.3071456 0.0002009154 7.185699e-02 1.464356e-01 5 138183688 138183756 69 + 2.325 2.293 -0.108
ENSG00000112984 E022 266.4665583 0.0002049645 9.542374e-01 9.753247e-01 5 138183962 138184105 144 + 2.421 2.435 0.047
ENSG00000112984 E023 309.2677252 0.0001884819 8.337111e-01 8.958469e-01 5 138184239 138184404 166 + 2.488 2.497 0.028
ENSG00000112984 E024 333.8647413 0.0001469417 1.441841e-01 2.536965e-01 5 138184512 138184676 165 + 2.501 2.542 0.137
ENSG00000112984 E025 167.9117161 0.0017761463 6.505161e-01 7.615531e-01 5 138184807 138184827 21 + 2.210 2.235 0.082
ENSG00000112984 E026 301.8958489 0.0019191006 8.118740e-01 8.806438e-01 5 138184828 138184946 119 + 2.470 2.486 0.053
ENSG00000112984 E027 266.1053266 0.0027585486 2.261997e-01 3.578467e-01 5 138185095 138185197 103 + 2.397 2.445 0.161
ENSG00000112984 E028 332.4658113 0.0004202183 1.284075e-06 1.041861e-05 5 138185512 138185710 199 + 2.454 2.569 0.381
ENSG00000112984 E029 245.2018913 0.0035341597 2.152072e-03 7.696081e-03 5 138185961 138186052 92 + 2.318 2.444 0.418
ENSG00000112984 E030 312.7102110 0.0029287898 5.908722e-04 2.500200e-03 5 138186294 138186431 138 + 2.424 2.548 0.414
ENSG00000112984 E031 611.3042213 0.0015304576 1.844626e-12 4.328735e-11 5 138187096 138187723 628 + 2.685 2.855 0.566