ENSG00000112983

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000230901 ENSG00000112983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD8 protein_coding protein_coding 63.65138 36.60558 79.16447 2.157292 0.6204509 1.112578 12.759404 10.4150704 7.817136 0.97009545 1.1135740 -0.41350069 0.21350000 0.28366667 0.09880000 -0.18486667 1.085779e-07 1.055057e-34 FALSE TRUE
ENST00000441656 ENSG00000112983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD8 protein_coding protein_coding 63.65138 36.60558 79.16447 2.157292 0.6204509 1.112578 10.363890 10.3438807 8.582647 0.85937339 0.5844954 -0.26899699 0.17946250 0.28266667 0.10833333 -0.17433333 1.297054e-12 1.055057e-34 FALSE TRUE
ENST00000463620 ENSG00000112983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD8 protein_coding retained_intron 63.65138 36.60558 79.16447 2.157292 0.6204509 1.112578 10.059810 2.8120316 13.414828 0.27023811 0.2640185 2.25009749 0.14407917 0.07746667 0.16946667 0.09200000 2.077411e-06 1.055057e-34 FALSE FALSE
ENST00000471892 ENSG00000112983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD8 protein_coding retained_intron 63.65138 36.60558 79.16447 2.157292 0.6204509 1.112578 7.422074 1.9009569 10.430098 0.04608062 0.8036062 2.44976805 0.10586250 0.05233333 0.13183333 0.07950000 5.065815e-07 1.055057e-34 FALSE TRUE
ENST00000472478 ENSG00000112983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD8 protein_coding nonsense_mediated_decay 63.65138 36.60558 79.16447 2.157292 0.6204509 1.112578 3.757918 2.8909838 2.846573 0.58312693 0.1386298 -0.02225672 0.06507917 0.07860000 0.03596667 -0.04263333 1.900586e-02 1.055057e-34   FALSE
ENST00000483805 ENSG00000112983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD8 protein_coding retained_intron 63.65138 36.60558 79.16447 2.157292 0.6204509 1.112578 3.827230 0.8809863 7.776808 0.15374850 0.4665632 3.12755693 0.05514583 0.02470000 0.09816667 0.07346667 4.962955e-06 1.055057e-34 FALSE FALSE
MSTRG.26991.10 ENSG00000112983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD8 protein_coding   63.65138 36.60558 79.16447 2.157292 0.6204509 1.112578 2.948657 0.6266179 6.623491 0.62661791 0.7441165 3.38126855 0.04329167 0.01736667 0.08360000 0.06623333 1.047955e-01 1.055057e-34 FALSE TRUE
MSTRG.26991.12 ENSG00000112983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD8 protein_coding   63.65138 36.60558 79.16447 2.157292 0.6204509 1.112578 2.381100 0.0000000 8.075192 0.00000000 0.7225420 9.65913820 0.03142083 0.00000000 0.10193333 0.10193333 1.055057e-34 1.055057e-34 FALSE TRUE
MSTRG.26991.14 ENSG00000112983 HEK293_OSMI2_2hA HEK293_TMG_2hB BRD8 protein_coding   63.65138 36.60558 79.16447 2.157292 0.6204509 1.112578 3.504789 2.7211736 4.672670 0.52100156 0.1044064 0.77781026 0.05600000 0.07526667 0.05906667 -0.01620000 7.351365e-01 1.055057e-34 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112983 E001 0.8083650 0.1271206886 3.458795e-01 4.900228e-01 5 138139770 138140166 397 - 0.327 0.140 -1.562
ENSG00000112983 E002 0.0000000       5 138140627 138140704 78 -      
ENSG00000112983 E003 0.9158732 0.2415282978 3.018583e-01 4.436853e-01 5 138140705 138140882 178 - 0.381 0.139 -1.891
ENSG00000112983 E004 0.6579068 0.5205502601 8.147561e-01 8.826267e-01 5 138145177 138145245 69 - 0.193 0.246 0.438
ENSG00000112983 E005 0.1817044 0.0413448769 3.710014e-01   5 138145789 138145878 90 - 0.000 0.139 10.879
ENSG00000112983 E006 0.1817044 0.0413448769 3.710014e-01   5 138149640 138149797 158 - 0.000 0.139 10.879
ENSG00000112983 E007 0.0000000       5 138150745 138151008 264 -      
ENSG00000112983 E008 0.1451727 0.0436277154 6.398067e-01   5 138152482 138152760 279 - 0.108 0.000 -11.007
ENSG00000112983 E009 1.8485056 0.2995313903 1.350420e-01 2.411472e-01 5 138156882 138156894 13 - 0.193 0.655 2.651
ENSG00000112983 E010 1.9936783 0.3220192242 2.495564e-01 3.853962e-01 5 138156895 138156895 1 - 0.265 0.655 2.065
ENSG00000112983 E011 2.1451937 0.2131281397 2.827359e-01 4.227750e-01 5 138156896 138156896 1 - 0.327 0.659 1.666
ENSG00000112983 E012 2.2967091 0.2066561876 3.999422e-01 5.436648e-01 5 138156897 138156898 2 - 0.381 0.660 1.344
ENSG00000112983 E013 11.7885033 0.0884231088 3.107384e-01 4.531724e-01 5 138156899 138156914 16 - 0.988 1.229 0.871
ENSG00000112983 E014 22.8973391 0.0245445038 3.781138e-02 8.698546e-02 5 138156915 138156928 14 - 1.259 1.497 0.827
ENSG00000112983 E015 467.2456048 0.0044913081 4.594491e-11 8.581411e-10 5 138156929 138157267 339 - 2.541 2.782 0.801
ENSG00000112983 E016 37.8068990 0.0052000871 8.978063e-02 1.747957e-01 5 138157642 138157894 253 - 1.530 1.649 0.407
ENSG00000112983 E017 103.9084734 0.0004179292 7.563828e-08 7.862521e-07 5 138159555 138159574 20 - 1.921 2.118 0.662
ENSG00000112983 E018 101.8989007 0.0017234662 4.252778e-07 3.814934e-06 5 138159575 138159599 25 - 1.906 2.116 0.706
ENSG00000112983 E019 215.6455254 0.0023346574 2.905354e-08 3.278986e-07 5 138160069 138160090 22 - 2.237 2.430 0.642
ENSG00000112983 E020 330.2505236 0.0006163497 8.408536e-15 2.798124e-13 5 138160091 138160173 83 - 2.429 2.609 0.601
ENSG00000112983 E021 178.7660671 0.0002930901 7.219571e-07 6.183210e-06 5 138160891 138160894 4 - 2.184 2.325 0.473
ENSG00000112983 E022 259.5436725 0.0001916636 2.207762e-11 4.349110e-10 5 138160895 138160967 73 - 2.339 2.496 0.523
ENSG00000112983 E023 256.5031794 0.0003758436 4.481885e-04 1.960108e-03 5 138160968 138161068 101 - 2.370 2.459 0.298
ENSG00000112983 E024 2.5955644 0.2603823443 3.406390e-01 4.845877e-01 5 138161069 138161235 167 - 0.669 0.395 -1.308
ENSG00000112983 E025 201.4680832 0.0005083671 4.184824e-03 1.366335e-02 5 138161796 138161864 69 - 2.269 2.352 0.278
ENSG00000112983 E026 5.1724288 0.0030111237 1.849864e-02 4.822900e-02 5 138161865 138162051 187 - 0.919 0.604 -1.278
ENSG00000112983 E027 1.8196646 0.0190908231 8.775195e-01 9.253122e-01 5 138162052 138162053 2 - 0.429 0.460 0.161
ENSG00000112983 E028 250.3781628 0.0022656424 3.281931e-04 1.493591e-03 5 138162054 138162146 93 - 2.341 2.462 0.402
ENSG00000112983 E029 463.0598271 0.0002022721 2.323122e-12 5.370262e-11 5 138163130 138163344 215 - 2.604 2.732 0.424
ENSG00000112983 E030 3.2065553 0.0049316096 7.823354e-01 8.602422e-01 5 138163587 138163643 57 - 0.641 0.604 -0.161
ENSG00000112983 E031 216.4727956 0.0002195817 2.491133e-05 1.511410e-04 5 138164087 138164133 47 - 2.284 2.394 0.367
ENSG00000112983 E032 307.0095863 0.0001724461 2.865156e-03 9.868285e-03 5 138164320 138164413 94 - 2.457 2.525 0.227
ENSG00000112983 E033 585.9452880 0.0001608709 4.229058e-01 5.660465e-01 5 138164714 138165021 308 - 2.774 2.769 -0.016
ENSG00000112983 E034 268.0361363 0.0001723726 2.535242e-02 6.259777e-02 5 138165022 138165111 90 - 2.453 2.411 -0.140
ENSG00000112983 E035 214.6251744 0.0002158089 7.162417e-02 1.460443e-01 5 138165112 138165166 55 - 2.354 2.316 -0.125
ENSG00000112983 E036 338.4139444 0.0008868340 5.143746e-03 1.632028e-02 5 138165828 138165998 171 - 2.560 2.498 -0.207
ENSG00000112983 E037 265.4409474 0.0002313534 1.110808e-04 5.727639e-04 5 138165999 138166108 110 - 2.464 2.384 -0.268
ENSG00000112983 E038 19.2871594 0.0009542719 1.393567e-12 3.334265e-11 5 138166109 138166225 117 - 1.500 0.870 -2.257
ENSG00000112983 E039 169.1075181 0.0002094812 1.464233e-02 3.969016e-02 5 138166518 138166610 93 - 2.261 2.201 -0.202
ENSG00000112983 E040 169.1332435 0.0002435964 2.863493e-02 6.927991e-02 5 138166611 138166727 117 - 2.259 2.205 -0.179
ENSG00000112983 E041 61.0684665 0.0003990079 1.163073e-23 1.110029e-21 5 138166728 138166945 218 - 1.961 1.466 -1.678
ENSG00000112983 E042 80.1747054 0.0003790669 4.729994e-36 1.235977e-33 5 138167643 138167933 291 - 2.091 1.534 -1.882
ENSG00000112983 E043 139.4641240 0.0012733165 3.696061e-03 1.228435e-02 5 138167934 138167986 53 - 2.193 2.100 -0.312
ENSG00000112983 E044 177.4436207 0.0071766785 1.049638e-02 2.997043e-02 5 138167987 138168078 92 - 2.306 2.185 -0.407
ENSG00000112983 E045 212.4368727 0.0013176007 1.242850e-04 6.335205e-04 5 138168470 138168688 219 - 2.379 2.270 -0.365
ENSG00000112983 E046 121.3113147 0.0002362113 3.858236e-04 1.720000e-03 5 138169222 138169262 41 - 2.138 2.029 -0.364
ENSG00000112983 E047 164.3427870 0.0002420213 4.252221e-04 1.871027e-03 5 138169263 138169349 87 - 2.263 2.170 -0.309
ENSG00000112983 E048 100.4891051 0.0025945181 3.414641e-02 8.004522e-02 5 138169350 138169358 9 - 2.047 1.959 -0.295
ENSG00000112983 E049 0.1451727 0.0436277154 6.398067e-01   5 138169363 138169388 26 - 0.108 0.000 -11.007
ENSG00000112983 E050 133.2091785 0.0012431037 3.246180e-02 7.673714e-02 5 138170345 138170380 36 - 2.161 2.091 -0.233
ENSG00000112983 E051 140.7337999 0.0025168742 3.702387e-02 8.551544e-02 5 138170381 138170409 29 - 2.186 2.109 -0.260
ENSG00000112983 E052 11.1050016 0.0046141725 4.652966e-08 5.051232e-07 5 138170730 138170831 102 - 1.278 0.643 -2.406
ENSG00000112983 E053 220.5432076 0.0027387348 4.669573e-04 2.033647e-03 5 138170832 138170912 81 - 2.398 2.278 -0.401
ENSG00000112983 E054 286.1357070 0.0016297564 2.901612e-07 2.693823e-06 5 138171038 138171160 123 - 2.521 2.376 -0.481
ENSG00000112983 E055 4.2093022 0.0036496277 1.165794e-03 4.524901e-03 5 138171345 138171360 16 - 0.889 0.399 -2.162
ENSG00000112983 E056 183.0317078 0.0030848266 1.609573e-07 1.571717e-06 5 138171361 138171410 50 - 2.348 2.150 -0.659
ENSG00000112983 E057 169.8535763 0.0009305751 1.267409e-07 1.262259e-06 5 138172065 138172134 70 - 2.303 2.145 -0.525
ENSG00000112983 E058 0.1472490 0.0435108350 6.397282e-01   5 138172720 138172826 107 - 0.108 0.000 -11.008
ENSG00000112983 E059 0.1472490 0.0435108350 6.397282e-01   5 138172827 138172851 25 - 0.108 0.000 -11.008
ENSG00000112983 E060 0.0000000       5 138177164 138177565 402 -      
ENSG00000112983 E061 1.7392274 0.0081852418 8.346350e-02 1.649787e-01 5 138177566 138177570 5 - 0.548 0.244 -1.745
ENSG00000112983 E062 153.2271830 0.0002511718 9.044665e-12 1.898177e-10 5 138177571 138177667 97 - 2.271 2.075 -0.655
ENSG00000112983 E063 110.3217008 0.0047639395 5.686946e-06 3.995901e-05 5 138178596 138178953 358 - 2.137 1.922 -0.721