ENSG00000112972

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000433297 ENSG00000112972 HEK293_OSMI2_2hA HEK293_TMG_2hB HMGCS1 protein_coding protein_coding 41.52505 14.96986 59.85491 0.2516737 2.723839 1.998686 24.813720 13.0728154 32.104245 0.7267910 0.8452435 1.295540 0.6610333 0.87336667 0.5374000 -0.3359667 0.004486938 0.001904375 FALSE TRUE
ENST00000507293 ENSG00000112972 HEK293_OSMI2_2hA HEK293_TMG_2hB HMGCS1 protein_coding retained_intron 41.52505 14.96986 59.85491 0.2516737 2.723839 1.998686 7.513421 1.2785075 13.524327 0.6396818 0.9951503 3.392850 0.1615375 0.08586667 0.2254000 0.1395333 0.518735108 0.001904375 FALSE TRUE
MSTRG.26135.4 ENSG00000112972 HEK293_OSMI2_2hA HEK293_TMG_2hB HMGCS1 protein_coding   41.52505 14.96986 59.85491 0.2516737 2.723839 1.998686 5.933071 0.1957407 9.328865 0.1463715 1.7376561 5.504348 0.1108917 0.01280000 0.1542667 0.1414667 0.002259424 0.001904375 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112972 E001 6.222121 0.0088206577 1.788301e-01 2.996747e-01 5 43287470 43289394 1925 - 0.753 0.978 0.869
ENSG00000112972 E002 997.731592 0.0029687314 4.427916e-22 3.555979e-20 5 43289395 43291005 1611 - 2.863 3.127 0.880
ENSG00000112972 E003 87.243463 0.0003000418 3.742769e-02 8.627249e-02 5 43291006 43291027 22 - 1.859 1.997 0.464
ENSG00000112972 E004 241.072670 0.0010884109 7.072258e-02 1.445405e-01 5 43291028 43291220 193 - 2.309 2.416 0.356
ENSG00000112972 E005 300.223020 0.0001688481 2.827387e-01 4.227758e-01 5 43292474 43292637 164 - 2.427 2.458 0.103
ENSG00000112972 E006 254.276674 0.0010775524 1.225867e-01 2.236379e-01 5 43292848 43292973 126 - 2.361 2.371 0.033
ENSG00000112972 E007 4.200997 0.0041080493 1.082428e-01 2.029400e-01 5 43293734 43294055 322 - 0.738 0.515 -0.974
ENSG00000112972 E008 252.474764 0.0008663172 1.123829e-01 2.090142e-01 5 43294056 43294162 107 - 2.358 2.368 0.034
ENSG00000112972 E009 2.064018 0.0077540811 5.978039e-03 1.854972e-02 5 43294413 43294690 278 - 0.557 0.000 -11.986
ENSG00000112972 E010 281.990237 0.0001914421 6.403171e-03 1.967084e-02 5 43294691 43294861 171 - 2.410 2.400 -0.032
ENSG00000112972 E011 229.901799 0.0023407568 2.549424e-02 6.290122e-02 5 43295752 43295917 166 - 2.325 2.300 -0.085
ENSG00000112972 E012 195.521453 0.0002193751 4.571171e-03 1.474074e-02 5 43297002 43297166 165 - 2.256 2.230 -0.088
ENSG00000112972 E013 8.066582 0.0026367285 4.030642e-02 9.159834e-02 5 43297529 43297669 141 - 0.972 0.744 -0.881
ENSG00000112972 E014 170.006390 0.0006066000 1.843062e-03 6.736688e-03 5 43298009 43298134 126 - 2.202 2.156 -0.153
ENSG00000112972 E015 6.890193 0.0080569561 8.495868e-05 4.514900e-04 5 43298144 43298445 302 - 0.963 0.330 -2.848
ENSG00000112972 E016 2.223952 0.0065538226 4.190474e-03 1.367944e-02 5 43298446 43298517 72 - 0.579 0.000 -12.086
ENSG00000112972 E017 223.496430 0.0008656439 7.138759e-09 9.040821e-08 5 43298518 43298678 161 - 2.338 2.217 -0.404
ENSG00000112972 E018 318.137969 0.0005742024 2.060459e-19 1.234106e-17 5 43298679 43298975 297 - 2.502 2.327 -0.583
ENSG00000112972 E019 66.624729 0.0024224215 1.226441e-07 1.224870e-06 5 43307766 43307824 59 - 1.842 1.587 -0.866
ENSG00000112972 E020 3.924921 0.0776465581 2.555018e-01 3.924027e-01 5 43307825 43307844 20 - 0.706 0.515 -0.847
ENSG00000112972 E021 1.624233 0.0083489338 1.679641e-02 4.448653e-02 5 43313022 43313355 334 - 0.484 0.000 -11.639
ENSG00000112972 E022 111.533361 0.0030170766 5.999706e-10 9.274796e-09 5 43313356 43313512 157 - 2.064 1.812 -0.849