ENSG00000112941

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000230859 ENSG00000112941 HEK293_OSMI2_2hA HEK293_TMG_2hB TENT4A protein_coding protein_coding 16.3952 16.2543 15.68363 0.4200251 0.4923302 -0.05152987 1.639953 1.111303 2.5325073 0.2446549 0.2054271 1.1810758 0.1016208 0.06843333 0.16173333 0.09330000 0.01675807 0.01675807 FALSE  
ENST00000514697 ENSG00000112941 HEK293_OSMI2_2hA HEK293_TMG_2hB TENT4A protein_coding retained_intron 16.3952 16.2543 15.68363 0.4200251 0.4923302 -0.05152987 2.126583 3.728873 0.4140504 2.0111795 0.4140504 -3.1402958 0.1242375 0.22763333 0.02786667 -0.19976667 0.42475012 0.01675807 FALSE  
ENST00000631941 ENSG00000112941 HEK293_OSMI2_2hA HEK293_TMG_2hB TENT4A protein_coding protein_coding 16.3952 16.2543 15.68363 0.4200251 0.4923302 -0.05152987 9.282242 9.430117 8.5106147 1.2359549 1.1153361 -0.1478472 0.5695542 0.58146667 0.54070000 -0.04076667 0.89743584 0.01675807 FALSE  
MSTRG.25910.5 ENSG00000112941 HEK293_OSMI2_2hA HEK293_TMG_2hB TENT4A protein_coding   16.3952 16.2543 15.68363 0.4200251 0.4923302 -0.05152987 1.710109 1.512701 2.1255688 0.3705182 0.3195695 0.4879875 0.1045333 0.09353333 0.13600000 0.04246667 0.53905615 0.01675807 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112941 E001 36.909515 0.0246281802 1.681990e-05 1.061134e-04 5 6713432 6714631 1200 + 1.718 1.389 -1.123
ENSG00000112941 E002 31.254234 0.0191890499 7.679070e-02 1.543595e-01 5 6714632 6714699 68 + 1.543 1.464 -0.270
ENSG00000112941 E003 0.147249 0.0427499415 4.540093e-01   5 6714700 6714788 89 + 0.117 0.000 -11.652
ENSG00000112941 E004 1.550134 0.1248506299 3.321636e-01 4.757856e-01 5 6714789 6714942 154 + 0.455 0.313 -0.812
ENSG00000112941 E005 2.798068 0.1386704647 3.098642e-01 4.522108e-01 5 6714943 6715119 177 + 0.642 0.491 -0.692
ENSG00000112941 E006 1.398519 0.0094410755 7.034296e-02 1.439277e-01 5 6725740 6725801 62 + 0.500 0.227 -1.655
ENSG00000112941 E007 81.310020 0.0007263610 8.522992e-03 2.509489e-02 5 6737510 6737633 124 + 1.923 1.897 -0.086
ENSG00000112941 E008 72.827364 0.0022849669 3.720729e-02 8.586474e-02 5 6738683 6738729 47 + 1.874 1.858 -0.053
ENSG00000112941 E009 103.564664 0.0035931803 6.326104e-03 1.947135e-02 5 6739732 6739852 121 + 2.037 1.998 -0.131
ENSG00000112941 E010 90.361339 0.0025714150 1.098011e-02 3.111387e-02 5 6742490 6742597 108 + 1.971 1.942 -0.100
ENSG00000112941 E011 86.344932 0.0074208213 1.261492e-02 3.500291e-02 5 6743712 6743840 129 + 1.966 1.910 -0.187
ENSG00000112941 E012 2.777570 0.0162051319 2.155166e-02 5.475033e-02 5 6745915 6745987 73 + 0.700 0.376 -1.544
ENSG00000112941 E013 5.224841 0.0040716221 4.599475e-03 1.481874e-02 5 6745988 6746213 226 + 0.925 0.611 -1.263
ENSG00000112941 E014 142.961004 0.0037953751 5.992689e-03 1.859161e-02 5 6746214 6746427 214 + 2.171 2.141 -0.100
ENSG00000112941 E015 114.005226 0.0078112738 4.392138e-02 9.824351e-02 5 6748464 6748590 127 + 2.072 2.046 -0.086
ENSG00000112941 E016 1.340242 0.0388420240 8.004168e-02 1.596174e-01 5 6749555 6749556 2 + 0.500 0.226 -1.663
ENSG00000112941 E017 105.919096 0.0051116104 1.716767e-02 4.531522e-02 5 6749557 6749657 101 + 2.046 2.012 -0.114
ENSG00000112941 E018 81.673789 0.0023492472 4.968057e-02 1.085914e-01 5 6750331 6750379 49 + 1.920 1.912 -0.025
ENSG00000112941 E019 120.036097 0.0107269994 1.480066e-02 4.004658e-02 5 6750380 6750503 124 + 2.114 2.049 -0.217
ENSG00000112941 E020 2.090970 0.0257228263 4.374548e-02 9.792149e-02 5 6750504 6750816 313 + 0.611 0.308 -1.579
ENSG00000112941 E021 150.187650 0.0009548154 1.278070e-05 8.283492e-05 5 6751039 6751197 159 + 2.206 2.150 -0.185
ENSG00000112941 E022 2.940059 0.0071608090 7.786458e-02 1.560512e-01 5 6751198 6751489 292 + 0.700 0.485 -0.964
ENSG00000112941 E023 149.303449 0.0002243693 1.278159e-01 2.311345e-01 5 6752873 6753037 165 + 2.155 2.191 0.123
ENSG00000112941 E024 61.048399 0.0004368286 9.620388e-01 9.800573e-01 5 6754751 6754753 3 + 1.746 1.827 0.277
ENSG00000112941 E025 1032.275342 0.0067281145 4.053178e-11 7.632068e-10 5 6754754 6757044 2291 + 2.862 3.118 0.852