ENSG00000112893

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261483 ENSG00000112893 HEK293_OSMI2_2hA HEK293_TMG_2hB MAN2A1 protein_coding protein_coding 5.343464 1.494128 7.452967 0.103278 0.1905507 2.310822 2.7617787 0.2241053 4.2971008 0.08401565 0.5691804 4.201487 0.4280417 0.1567667 0.5736000 0.41683333 0.002530515 0.002530515 FALSE TRUE
MSTRG.26716.2 ENSG00000112893 HEK293_OSMI2_2hA HEK293_TMG_2hB MAN2A1 protein_coding   5.343464 1.494128 7.452967 0.103278 0.1905507 2.310822 0.3991045 0.1588296 0.7257759 0.10314140 0.2099525 2.123699 0.0743750 0.1116333 0.0989000 -0.01273333 0.967455565 0.002530515 TRUE TRUE
MSTRG.26716.3 ENSG00000112893 HEK293_OSMI2_2hA HEK293_TMG_2hB MAN2A1 protein_coding   5.343464 1.494128 7.452967 0.103278 0.1905507 2.310822 1.9946089 1.0497825 2.2244585 0.21551126 0.2330414 1.076157 0.4376917 0.6904667 0.3001333 -0.39033333 0.010629340 0.002530515 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112893 E001 17.5258030 0.0146049515 3.120868e-02 7.430520e-02 5 109689927 109690194 268 + 1.162 0.969 -0.702
ENSG00000112893 E002 27.1908889 0.0120223512 8.571294e-05 4.549751e-04 5 109690195 109690552 358 + 1.358 0.970 -1.390
ENSG00000112893 E003 1.0717687 0.0608684559 9.178978e-01 9.521183e-01 5 109691838 109691902 65 + 0.247 0.263 0.118
ENSG00000112893 E004 34.5134171 0.0005740786 1.100254e-02 3.116798e-02 5 109713520 109713774 255 + 1.432 1.321 -0.385
ENSG00000112893 E005 31.2874433 0.0006901664 1.767332e-02 4.643357e-02 5 109716120 109716264 145 + 1.391 1.285 -0.370
ENSG00000112893 E006 28.7532583 0.0087435495 2.064634e-01 3.342837e-01 5 109729342 109729513 172 + 1.346 1.320 -0.087
ENSG00000112893 E007 18.6669010 0.0154929015 8.249303e-01 8.896967e-01 5 109755329 109755456 128 + 1.154 1.224 0.250
ENSG00000112893 E008 27.4819467 0.0008923600 2.833500e-03 9.774359e-03 5 109767535 109767708 174 + 1.346 1.155 -0.673
ENSG00000112893 E009 36.1898206 0.0006170864 4.670818e-02 1.033112e-01 5 109770355 109770541 187 + 1.442 1.385 -0.198
ENSG00000112893 E010 34.2849102 0.0006258043 1.410196e-02 3.845708e-02 5 109774788 109774965 178 + 1.426 1.321 -0.364
ENSG00000112893 E011 35.6115012 0.0006152481 3.877280e-04 1.727316e-03 5 109781396 109781598 203 + 1.454 1.246 -0.724
ENSG00000112893 E012 32.6495178 0.0016290536 1.182651e-03 4.582541e-03 5 109784744 109784926 183 + 1.419 1.225 -0.679
ENSG00000112893 E013 25.9175868 0.0135182570 8.480190e-02 1.670858e-01 5 109788934 109789048 115 + 1.312 1.223 -0.312
ENSG00000112893 E014 20.9227192 0.0076325955 2.127263e-01 3.417544e-01 5 109789460 109789527 68 + 1.216 1.179 -0.130
ENSG00000112893 E015 0.1451727 0.0433800815 1.000000e+00   5 109794175 109794237 63 + 0.052 0.000 -10.852
ENSG00000112893 E016 2.7657016 0.1345755095 2.390719e-01 3.730178e-01 5 109804154 109804175 22 + 0.403 0.719 1.468
ENSG00000112893 E017 2.6979619 0.0060393619 4.528555e-01 5.936554e-01 5 109804176 109804277 102 + 0.425 0.636 1.002
ENSG00000112893 E018 27.8981009 0.0164012247 9.159768e-01 9.508702e-01 5 109817273 109817438 166 + 1.312 1.400 0.305
ENSG00000112893 E019 42.6821565 0.0006337971 2.649770e-01 4.029887e-01 5 109819669 109819887 219 + 1.500 1.523 0.081
ENSG00000112893 E020 31.1656615 0.0114213243 1.801046e-01 3.013046e-01 5 109820220 109820342 123 + 1.375 1.340 -0.123
ENSG00000112893 E021 31.9423248 0.0007853673 2.435669e-01 3.783703e-01 5 109823723 109823837 115 + 1.380 1.385 0.018
ENSG00000112893 E022 35.2629327 0.0006379450 4.656171e-01 6.052792e-01 5 109842328 109842461 134 + 1.419 1.466 0.160
ENSG00000112893 E023 37.2849293 0.0005739773 5.792319e-01 7.041797e-01 5 109845865 109846006 142 + 1.440 1.501 0.211
ENSG00000112893 E024 36.8389691 0.0037679397 3.253779e-01 4.688236e-01 5 109847657 109847790 134 + 1.442 1.465 0.081
ENSG00000112893 E025 0.9223296 0.0136968632 1.000000e+00 1.000000e+00 5 109853581 109854921 1341 + 0.214 0.263 0.380
ENSG00000112893 E026 0.1515154 0.0433964788 1.000000e+00   5 109854922 109855139 218 + 0.052 0.000 -10.853
ENSG00000112893 E027 47.8501630 0.0033165857 6.278094e-01 7.435202e-01 5 109855140 109855334 195 + 1.532 1.668 0.464
ENSG00000112893 E028 5.7346591 0.0027760080 6.314644e-01 7.464638e-01 5 109862328 109865035 2708 + 0.706 0.712 0.025
ENSG00000112893 E029 38.5493147 0.0029809628 1.929791e-01 3.175177e-01 5 109865036 109865146 111 + 1.465 1.465 0.001
ENSG00000112893 E030 0.2934659 0.0291077058 2.367899e-01   5 109865147 109865415 269 + 0.052 0.262 2.700
ENSG00000112893 E031 326.5239255 0.0165184771 4.663071e-07 4.150363e-06 5 109866846 109869625 2780 + 2.306 2.639 1.112