ENSG00000112851

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284037 ENSG00000112851 HEK293_OSMI2_2hA HEK293_TMG_2hB ERBIN protein_coding protein_coding 4.506714 1.558856 7.317457 0.1015972 0.4042731 2.2236 0.22715857 0.0355783 0.5168370 0.02057227 0.2584831 3.530938 0.05920833 0.02213333 0.07390000 0.05176667 0.84759434 0.00076396 FALSE  
ENST00000380935 ENSG00000112851 HEK293_OSMI2_2hA HEK293_TMG_2hB ERBIN protein_coding protein_coding 4.506714 1.558856 7.317457 0.1015972 0.4042731 2.2236 1.17454049 0.1753749 1.7800071 0.09076328 0.1991946 3.271448 0.19542917 0.10793333 0.24560000 0.13766667 0.24438601 0.00076396 FALSE  
ENST00000380943 ENSG00000112851 HEK293_OSMI2_2hA HEK293_TMG_2hB ERBIN protein_coding protein_coding 4.506714 1.558856 7.317457 0.1015972 0.4042731 2.2236 2.08249085 0.4933256 3.3503375 0.26672301 0.4568023 2.739042 0.39960417 0.34133333 0.45386667 0.11253333 0.81336495 0.00076396 FALSE  
ENST00000503913 ENSG00000112851 HEK293_OSMI2_2hA HEK293_TMG_2hB ERBIN protein_coding processed_transcript 4.506714 1.558856 7.317457 0.1015972 0.4042731 2.2236 0.14703903 0.3456513 0.0000000 0.34565135 0.0000000 -5.152392 0.09789167 0.19880000 0.00000000 -0.19880000 0.54788118 0.00076396    
ENST00000509946 ENSG00000112851 HEK293_OSMI2_2hA HEK293_TMG_2hB ERBIN protein_coding retained_intron 4.506714 1.558856 7.317457 0.1015972 0.4042731 2.2236 0.01773028 0.1226418 0.0000000 0.12264178 0.0000000 -3.729463 0.01141250 0.08843333 0.00000000 -0.08843333 0.53814124 0.00076396    
ENST00000511297 ENSG00000112851 HEK293_OSMI2_2hA HEK293_TMG_2hB ERBIN protein_coding protein_coding 4.506714 1.558856 7.317457 0.1015972 0.4042731 2.2236 0.36320078 0.0000000 0.6314076 0.00000000 0.1366618 6.003170 0.08567500 0.00000000 0.08543333 0.08543333 0.00076396 0.00076396 FALSE  
MSTRG.26277.7 ENSG00000112851 HEK293_OSMI2_2hA HEK293_TMG_2hB ERBIN protein_coding   4.506714 1.558856 7.317457 0.1015972 0.4042731 2.2236 0.06201820 0.1479243 0.0254559 0.14792429 0.0254559 -2.155135 0.02460417 0.08506667 0.00340000 -0.08166667 0.66721495 0.00076396 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112851 E001 6.6664294 0.0029183827 5.185173e-02 1.124574e-01 5 65926556 65926560 5 + 0.734 0.479 -1.137
ENSG00000112851 E002 6.1482961 0.0034182022 1.415523e-02 3.857790e-02 5 65926561 65926566 6 + 0.717 0.302 -2.067
ENSG00000112851 E003 6.2934688 0.0027653263 1.229642e-02 3.424556e-02 5 65926567 65926573 7 + 0.726 0.302 -2.103
ENSG00000112851 E004 5.4055945 0.0031994694 2.733423e-02 6.667596e-02 5 65926574 65926574 1 + 0.671 0.302 -1.874
ENSG00000112851 E005 16.4044770 0.0012206465 7.407818e-03 2.227884e-02 5 65926575 65926609 35 + 1.074 0.847 -0.847
ENSG00000112851 E006 27.3458464 0.0007710117 3.338522e-02 7.854758e-02 5 65926610 65926726 117 + 1.267 1.206 -0.213
ENSG00000112851 E007 25.7450216 0.0009054148 6.811834e-02 1.402453e-01 5 65926727 65926772 46 + 1.239 1.206 -0.114
ENSG00000112851 E008 24.0881339 0.0099471549 1.844781e-02 4.811595e-02 5 65926773 65926806 34 + 1.222 1.082 -0.501
ENSG00000112851 E009 0.5954526 0.0184069781 7.711606e-01 8.522580e-01 5 65984755 65984845 91 + 0.153 0.000 -9.723
ENSG00000112851 E010 0.0000000       5 65988633 65988634 2 +      
ENSG00000112851 E011 22.7768102 0.0084995584 2.328528e-03 8.239154e-03 5 65988635 65988682 48 + 1.208 0.957 -0.911
ENSG00000112851 E012 22.1991688 0.0008482838 1.326277e-04 6.703644e-04 5 65992710 65992816 107 + 1.203 0.847 -1.310
ENSG00000112851 E013 21.4765250 0.0011632930 2.720609e-03 9.434409e-03 5 65992817 65992907 91 + 1.179 0.956 -0.811
ENSG00000112851 E014 25.5348554 0.0077292043 3.531529e-03 1.181690e-02 5 65994747 65994864 118 + 1.249 1.045 -0.733
ENSG00000112851 E015 21.5963493 0.0008816001 1.233587e-01 2.247477e-01 5 66012049 66012127 79 + 1.164 1.148 -0.056
ENSG00000112851 E016 26.4713394 0.0009622890 1.331225e-02 3.664688e-02 5 66013549 66013638 90 + 1.257 1.148 -0.384
ENSG00000112851 E017 24.2826269 0.0117370262 3.749121e-03 1.243713e-02 5 66014669 66014725 57 + 1.233 1.003 -0.829
ENSG00000112851 E018 25.2833200 0.0124705147 5.604652e-03 1.756497e-02 5 66021322 66021385 64 + 1.249 1.044 -0.735
ENSG00000112851 E019 0.0000000       5 66022872 66023289 418 +      
ENSG00000112851 E020 25.0702793 0.0049490742 3.270077e-03 1.106202e-02 5 66023290 66023364 75 + 1.244 1.044 -0.717
ENSG00000112851 E021 26.3583089 0.0007176540 3.340879e-04 1.516701e-03 5 66024306 66024450 145 + 1.267 1.002 -0.950
ENSG00000112851 E022 2.6541571 0.0060327490 8.475038e-01 9.053067e-01 5 66025306 66025479 174 + 0.412 0.479 0.349
ENSG00000112851 E023 19.8793958 0.0059433065 1.165484e-03 4.523798e-03 5 66025480 66025552 73 + 1.154 0.848 -1.134
ENSG00000112851 E024 26.3207476 0.0006988812 5.810502e-06 4.075462e-05 5 66025848 66025977 130 + 1.277 0.847 -1.570
ENSG00000112851 E025 29.2597502 0.0007184693 4.614728e-05 2.622687e-04 5 66026302 66026417 116 + 1.314 1.002 -1.114
ENSG00000112851 E026 19.5315151 0.0014135702 1.976460e-02 5.098785e-02 5 66028274 66028343 70 + 1.138 1.002 -0.494
ENSG00000112851 E027 30.9923030 0.0009484921 1.253242e-02 3.481070e-02 5 66038383 66038482 100 + 1.320 1.233 -0.307
ENSG00000112851 E028 32.7602414 0.0006466806 3.820874e-04 1.705463e-03 5 66043077 66043198 122 + 1.354 1.148 -0.724
ENSG00000112851 E029 37.2124454 0.0005861009 2.987115e-02 7.171280e-02 5 66044137 66044298 162 + 1.393 1.364 -0.100
ENSG00000112851 E030 14.3886527 0.0012287767 4.707008e-01 6.099291e-01 5 66044299 66044310 12 + 0.970 1.206 0.858
ENSG00000112851 E031 45.2434254 0.0004966250 1.566565e-01 2.706474e-01 5 66046353 66046538 186 + 1.466 1.521 0.188
ENSG00000112851 E032 36.3846859 0.0005601289 6.816379e-03 2.074546e-02 5 66048667 66048781 115 + 1.389 1.303 -0.298
ENSG00000112851 E033 44.7276496 0.0138219690 1.609735e-02 4.295386e-02 5 66050783 66050966 184 + 1.476 1.398 -0.266
ENSG00000112851 E034 173.8478707 0.0005754005 2.999563e-01 4.415714e-01 5 66053406 66054632 1227 + 2.027 2.155 0.428
ENSG00000112851 E035 74.1139461 0.0004257583 8.936353e-01 9.359605e-01 5 66054633 66054951 319 + 1.659 1.815 0.530
ENSG00000112851 E036 0.0000000       5 66055062 66055126 65 +      
ENSG00000112851 E037 1.7757486 0.0077177634 1.293622e-01 2.332893e-01 5 66068877 66069020 144 + 0.355 0.000 -11.158
ENSG00000112851 E038 3.1196512 0.0754472875 6.479161e-01 7.595043e-01 5 66072169 66072291 123 + 0.477 0.478 0.005
ENSG00000112851 E039 0.1515154 0.0429590103 8.516086e-01   5 66072292 66072294 3 + 0.044 0.000 -7.645
ENSG00000112851 E040 24.3457910 0.0023549102 7.631436e-01 8.465684e-01 5 66075024 66075145 122 + 1.197 1.325 0.448
ENSG00000112851 E041 23.2580289 0.0008333751 5.795121e-01 7.044164e-01 5 66075146 66075230 85 + 1.179 1.281 0.359
ENSG00000112851 E042 0.3666179 0.0281903644 1.755950e-01 2.954609e-01 5 66076110 66076315 206 + 0.043 0.303 3.258
ENSG00000112851 E043 38.5748625 0.0005410794 7.604665e-01 8.445729e-01 5 66076316 66076408 93 + 1.383 1.521 0.474
ENSG00000112851 E044 0.4762024 0.2815886348 3.659783e-01 5.103079e-01 5 66076409 66076874 466 + 0.083 0.303 2.260
ENSG00000112851 E045 36.8845013 0.0168816645 3.438182e-01 4.878722e-01 5 66076875 66076949 75 + 1.345 1.598 0.870
ENSG00000112851 E046 281.9555599 0.0326004083 7.493253e-11 1.348252e-09 5 66078423 66082546 4124 + 2.123 2.738 2.051