ENSG00000112837

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330469 ENSG00000112837 HEK293_OSMI2_2hA HEK293_TMG_2hB TBX18 protein_coding retained_intron 4.873808 3.632215 5.89624 0.301231 0.1992306 0.6974237 0.4611782 0.3692731 0.5075811 0.28549669 0.35254429 0.4485479 0.10195417 0.09063333 0.08266667 -0.007966667 1.00000000 0.005908489   FALSE
ENST00000369663 ENSG00000112837 HEK293_OSMI2_2hA HEK293_TMG_2hB TBX18 protein_coding protein_coding 4.873808 3.632215 5.89624 0.301231 0.1992306 0.6974237 1.7639345 1.0702886 2.6106099 0.15904900 0.07026754 1.2784858 0.33743333 0.29180000 0.44323333 0.151433333 0.02043726 0.005908489 FALSE TRUE
ENST00000606784 ENSG00000112837 HEK293_OSMI2_2hA HEK293_TMG_2hB TBX18 protein_coding protein_coding 4.873808 3.632215 5.89624 0.301231 0.1992306 0.6974237 0.1535122 0.4515934 0.0000000 0.22651712 0.00000000 -5.5285507 0.04429167 0.13556667 0.00000000 -0.135566667 0.10434354 0.005908489 FALSE TRUE
MSTRG.28602.4 ENSG00000112837 HEK293_OSMI2_2hA HEK293_TMG_2hB TBX18 protein_coding   4.873808 3.632215 5.89624 0.301231 0.1992306 0.6974237 0.2774684 0.2826312 0.2180893 0.14132891 0.11146624 -0.3594848 0.07382917 0.08466667 0.03590000 -0.048766667 0.83179868 0.005908489 FALSE TRUE
MSTRG.28602.9 ENSG00000112837 HEK293_OSMI2_2hA HEK293_TMG_2hB TBX18 protein_coding   4.873808 3.632215 5.89624 0.301231 0.1992306 0.6974237 1.2290587 0.9763311 1.4835649 0.09663201 0.09469640 0.5986160 0.24842083 0.27666667 0.25326667 -0.023400000 0.89818337 0.005908489 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112837 E001 0.1451727 0.0435937998 0.773922771   6 84687351 84687372 22 - 0.101 0.000 -8.197
ENSG00000112837 E002 2.5485599 0.0066083154 0.339251185 0.483154060 6 84687373 84687475 103 - 0.491 0.626 0.622
ENSG00000112837 E003 4.0233619 0.0041227508 0.046883689 0.103620960 6 84687476 84687536 61 - 0.559 0.823 1.109
ENSG00000112837 E004 3.5731838 0.0105512830 0.083636686 0.165238495 6 84687537 84687550 14 - 0.526 0.768 1.041
ENSG00000112837 E005 7.7969890 0.0884078890 0.016577164 0.044010399 6 84687551 84687634 84 - 0.738 1.121 1.452
ENSG00000112837 E006 7.9912389 0.0240477274 0.001368061 0.005202648 6 84687635 84687678 44 - 0.737 1.140 1.520
ENSG00000112837 E007 5.5923373 0.0212683721 0.259312611 0.396697848 6 84688581 84688667 87 - 0.758 0.894 0.533
ENSG00000112837 E008 2.3764074 0.0339203915 0.902656288 0.942018310 6 84688668 84688747 80 - 0.526 0.534 0.033
ENSG00000112837 E009 214.2290798 0.0102915666 0.007096424 0.021479409 6 84732496 84737056 4561 - 2.378 2.257 -0.404
ENSG00000112837 E010 48.0015660 0.0004925441 0.292415442 0.433390144 6 84737057 84737409 353 - 1.721 1.645 -0.257
ENSG00000112837 E011 39.7574853 0.0034644395 0.044783075 0.099811992 6 84738497 84738591 95 - 1.567 1.664 0.328
ENSG00000112837 E012 3.1335937 0.0071709098 0.087987824 0.172060294 6 84741067 84741802 736 - 0.716 0.418 -1.375
ENSG00000112837 E013 3.1593033 0.0659516613 0.116616129 0.215129599 6 84742024 84742548 525 - 0.736 0.416 -1.470
ENSG00000112837 E014 29.3711889 0.0138767050 0.569177087 0.695779859 6 84744261 84744325 65 - 1.471 1.502 0.108
ENSG00000112837 E015 49.1383158 0.0005113584 0.145592129 0.255665787 6 84747920 84748087 168 - 1.678 1.725 0.159
ENSG00000112837 E016 39.5727459 0.0014499210 0.085044982 0.167480610 6 84756698 84756869 172 - 1.570 1.642 0.244
ENSG00000112837 E017 18.5716193 0.0032504167 0.659378481 0.768201680 6 84760255 84760282 28 - 1.281 1.292 0.040
ENSG00000112837 E018 23.8156924 0.0273905185 0.211870222 0.340699748 6 84760283 84760356 74 - 1.342 1.441 0.343
ENSG00000112837 E019 27.6230665 0.0143326409 0.985905649 0.995198518 6 84762544 84762748 205 - 1.463 1.432 -0.106
ENSG00000112837 E020 3.9525798 0.0056748499 0.300257303 0.441924383 6 84762918 84763423 506 - 0.757 0.583 -0.739
ENSG00000112837 E021 2.9850189 0.0057087375 0.015427843 0.041462861 6 84763424 84763594 171 - 0.410 0.767 1.623
ENSG00000112837 E022 34.4017910 0.0006906448 0.015809516 0.042309756 6 84763890 84764598 709 - 1.611 1.442 -0.580