ENSG00000112812

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377456 ENSG00000112812 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS16 protein_coding processed_transcript 4.68784 6.830489 3.537259 0.3890139 0.2902664 -0.9473946 0.3103477 0.6565148 0.1765002 0.18692238 0.07829129 -1.8374596 0.06472083 0.09483333 0.05053333 -0.04430000 0.47656729 0.03086171 FALSE  
ENST00000462664 ENSG00000112812 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS16 protein_coding retained_intron 4.68784 6.830489 3.537259 0.3890139 0.2902664 -0.9473946 0.2579906 0.2109922 0.1134698 0.04553878 0.05775452 -0.8398370 0.06119167 0.03143333 0.03033333 -0.00110000 0.99595849 0.03086171 FALSE  
ENST00000468138 ENSG00000112812 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS16 protein_coding processed_transcript 4.68784 6.830489 3.537259 0.3890139 0.2902664 -0.9473946 1.5332187 1.8932067 0.7414619 0.24030406 0.19774839 -1.3406605 0.33425833 0.27663333 0.21033333 -0.06630000 0.67647962 0.03086171 FALSE  
ENST00000481125 ENSG00000112812 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS16 protein_coding retained_intron 4.68784 6.830489 3.537259 0.3890139 0.2902664 -0.9473946 0.3363247 0.5108343 0.4530011 0.25786082 0.06919835 -0.1698086 0.07834583 0.07460000 0.13013333 0.05553333 0.66646066 0.03086171 FALSE  
ENST00000485603 ENSG00000112812 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS16 protein_coding retained_intron 4.68784 6.830489 3.537259 0.3890139 0.2902664 -0.9473946 0.3577292 0.1216321 0.2504099 0.03640497 0.04554300 0.9842733 0.08214167 0.01850000 0.07056667 0.05206667 0.03086171 0.03086171 FALSE  
ENST00000488649 ENSG00000112812 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS16 protein_coding retained_intron 4.68784 6.830489 3.537259 0.3890139 0.2902664 -0.9473946 0.7445812 1.6234119 0.3148792 0.14952395 0.17145006 -2.3299133 0.14727500 0.23710000 0.08296667 -0.15413333 0.27443516 0.03086171 FALSE  
ENST00000492575 ENSG00000112812 HEK293_OSMI2_2hA HEK293_TMG_2hB PRSS16 protein_coding retained_intron 4.68784 6.830489 3.537259 0.3890139 0.2902664 -0.9473946 0.6364998 0.9653155 0.6619127 0.34129717 0.21531231 -0.5375952 0.12399167 0.14273333 0.18906667 0.04633333 0.81286509 0.03086171 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112812 E001 0.1472490 0.0429133339 2.220164e-01   6 27247701 27247730 30 + 0.171 0.000 -11.549
ENSG00000112812 E002 0.1472490 0.0429133339 2.220164e-01   6 27247731 27247807 77 + 0.171 0.000 -13.392
ENSG00000112812 E003 0.0000000       6 27247882 27248048 167 +      
ENSG00000112812 E004 0.0000000       6 27248847 27248935 89 +      
ENSG00000112812 E005 0.0000000       6 27248936 27248946 11 +      
ENSG00000112812 E006 0.0000000       6 27249100 27249229 130 +      
ENSG00000112812 E007 0.1817044 0.0390986329 1.000000e+00   6 27250683 27250806 124 + 0.000 0.086 11.025
ENSG00000112812 E008 0.7353121 0.1587066809 4.894550e-01 0.6268855996 6 27251042 27251070 29 + 0.293 0.161 -1.104
ENSG00000112812 E009 1.0287780 0.0268890711 3.562853e-01 0.5006689140 6 27251071 27251119 49 + 0.389 0.220 -1.132
ENSG00000112812 E010 0.1472490 0.0429133339 2.220164e-01   6 27251120 27251192 73 + 0.171 0.000 -13.392
ENSG00000112812 E011 1.4652396 0.0106944442 1.370916e-01 0.2440435273 6 27251193 27251193 1 + 0.533 0.274 -1.457
ENSG00000112812 E012 2.6035255 0.0085297731 9.922759e-01 0.9992621324 6 27251194 27251201 8 + 0.533 0.533 0.000
ENSG00000112812 E013 5.0600159 0.0223948105 9.152387e-01 0.9503434901 6 27251202 27251212 11 + 0.728 0.749 0.087
ENSG00000112812 E014 5.9081468 0.0111885064 9.693936e-01 0.9848700188 6 27251213 27251216 4 + 0.800 0.797 -0.010
ENSG00000112812 E015 12.6342225 0.0070741218 7.028407e-01 0.8016222202 6 27251217 27251264 48 + 1.116 1.078 -0.135
ENSG00000112812 E016 0.2965864 0.2126574316 5.806566e-01   6 27251299 27251321 23 + 0.000 0.155 11.573
ENSG00000112812 E017 1.5832421 0.0645923875 5.824109e-01 0.7067746250 6 27251322 27251501 180 + 0.467 0.363 -0.563
ENSG00000112812 E018 0.6330284 0.0743348976 4.479506e-01 0.5893011102 6 27251588 27251619 32 + 0.294 0.158 -1.143
ENSG00000112812 E019 4.2902485 0.0590206843 9.481444e-01 0.9714398246 6 27251620 27251661 42 + 0.686 0.692 0.025
ENSG00000112812 E020 11.1290981 0.0016796773 9.651255e-02 0.1851320605 6 27251662 27251749 88 + 0.890 1.078 0.701
ENSG00000112812 E021 33.7074130 0.0072901985 6.267189e-01 0.7426195035 6 27251750 27252040 291 + 1.462 1.502 0.138
ENSG00000112812 E022 1.2178693 0.0105897693 8.797677e-01 0.9268469656 6 27252041 27252270 230 + 0.293 0.322 0.186
ENSG00000112812 E023 34.9653877 0.0050837271 7.545713e-01 0.8401637051 6 27252808 27252949 142 + 1.516 1.497 -0.066
ENSG00000112812 E024 9.5061702 0.0159134533 1.696334e-06 0.0000134053 6 27252986 27254692 1707 + 1.297 0.748 -2.032
ENSG00000112812 E025 35.4907553 0.0077217688 8.042546e-01 0.8754818997 6 27254693 27254872 180 + 1.503 1.521 0.061
ENSG00000112812 E026 54.4151713 0.0005964868 4.494404e-01 0.5906416743 6 27254986 27255131 146 + 1.671 1.710 0.132
ENSG00000112812 E027 190.4001301 0.0052931771 3.759839e-01 0.5203566376 6 27255247 27256624 1378 + 2.214 2.239 0.085