ENSG00000112787

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000542061 ENSG00000112787 HEK293_OSMI2_2hA HEK293_TMG_2hB FBRSL1 protein_coding protein_coding 64.09564 86.9933 50.82674 8.993026 0.7170744 -0.7751987 17.107185 31.114260 5.608467 2.4431283 0.2671091 -2.46979095 0.24745417 0.35970000 0.1104000 -0.24930000 2.267351e-37 2.267351e-37 FALSE TRUE
ENST00000542306 ENSG00000112787 HEK293_OSMI2_2hA HEK293_TMG_2hB FBRSL1 protein_coding retained_intron 64.09564 86.9933 50.82674 8.993026 0.7170744 -0.7751987 8.572178 9.165990 8.706180 0.9997156 0.3234445 -0.07416781 0.15214583 0.10666667 0.1712333 0.06456667 1.282292e-02 2.267351e-37 FALSE FALSE
MSTRG.8347.16 ENSG00000112787 HEK293_OSMI2_2hA HEK293_TMG_2hB FBRSL1 protein_coding   64.09564 86.9933 50.82674 8.993026 0.7170744 -0.7751987 10.175089 14.874939 7.347791 1.4071160 0.2293302 -1.01650872 0.15405833 0.17216667 0.1447333 -0.02743333 4.228465e-01 2.267351e-37 FALSE TRUE
MSTRG.8347.18 ENSG00000112787 HEK293_OSMI2_2hA HEK293_TMG_2hB FBRSL1 protein_coding   64.09564 86.9933 50.82674 8.993026 0.7170744 -0.7751987 6.001195 4.942048 5.845726 2.5405153 1.9854418 0.24182256 0.09094167 0.05150000 0.1152667 0.06376667 7.001857e-01 2.267351e-37 FALSE TRUE
MSTRG.8347.21 ENSG00000112787 HEK293_OSMI2_2hA HEK293_TMG_2hB FBRSL1 protein_coding   64.09564 86.9933 50.82674 8.993026 0.7170744 -0.7751987 3.786772 6.833197 2.972276 0.5015015 1.5932546 -1.19825669 0.06221667 0.07906667 0.0588000 -0.02026667 7.935192e-01 2.267351e-37 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112787 E001 0.5159433 0.2183046343 3.326626e-01 4.763382e-01 12 132489551 132490150 600 + 0.267 0.098 -1.747
ENSG00000112787 E002 0.8147077 0.1172556204 6.221204e-02 1.303676e-01 12 132490151 132490164 14 + 0.431 0.097 -2.758
ENSG00000112787 E003 3.3611567 0.0403248595 1.187987e-06 9.708840e-06 12 132490165 132490252 88 + 0.978 0.176 -4.087
ENSG00000112787 E004 3.8352723 0.0474516970 2.915225e-10 4.754483e-09 12 132490253 132490371 119 + 1.081 0.000 -14.038
ENSG00000112787 E005 17.2332505 0.0013221547 8.547732e-34 1.911856e-31 12 132490372 132490707 336 + 1.651 0.573 -3.996
ENSG00000112787 E006 8.6486736 0.0019256812 3.113074e-20 2.039290e-18 12 132490708 132490737 30 + 1.379 0.300 -4.525
ENSG00000112787 E007 18.2879513 0.0017804412 1.755425e-16 7.326723e-15 12 132490738 132490777 40 + 1.570 0.929 -2.270
ENSG00000112787 E008 66.3473334 0.0014105801 2.995364e-05 1.783072e-04 12 132490778 132490861 84 + 1.899 1.740 -0.536
ENSG00000112787 E009 0.5880631 0.2232797537 1.000000e+00 1.000000e+00 12 132507030 132507085 56 + 0.154 0.180 0.274
ENSG00000112787 E010 6.2323432 0.0028877411 8.926873e-01 9.354317e-01 12 132507252 132507388 137 + 0.815 0.829 0.055
ENSG00000112787 E011 50.0441364 0.0013696464 1.352655e-02 3.714129e-02 12 132508153 132508155 3 + 1.740 1.645 -0.322
ENSG00000112787 E012 205.4831719 0.0004739786 5.339263e-01 6.660482e-01 12 132508156 132508350 195 + 2.242 2.298 0.184
ENSG00000112787 E013 1869.9820218 0.0022621210 3.657461e-57 3.315288e-54 12 132509166 132511952 2787 + 2.941 3.338 1.320
ENSG00000112787 E014 53.5756836 0.0004359919 6.302368e-10 9.712558e-09 12 132525734 132525823 90 + 1.862 1.598 -0.893
ENSG00000112787 E015 27.9293305 0.0016808849 4.064053e-04 1.799347e-03 12 132527953 132527988 36 + 1.559 1.356 -0.701
ENSG00000112787 E016 28.7839825 0.0007625364 6.775200e-06 4.682065e-05 12 132548003 132548032 30 + 1.598 1.341 -0.884
ENSG00000112787 E017 2.5571693 0.0079328603 1.386554e-03 5.263042e-03 12 132559982 132560003 22 + 0.785 0.301 -2.354
ENSG00000112787 E018 3.5965590 0.0071441530 4.612593e-06 3.310509e-05 12 132560004 132560004 1 + 0.958 0.301 -3.017
ENSG00000112787 E019 9.6485288 0.0026347634 1.397694e-12 3.343716e-11 12 132560005 132560022 18 + 1.339 0.601 -2.798
ENSG00000112787 E020 16.2831759 0.0012446012 2.346948e-17 1.089760e-15 12 132560023 132560042 20 + 1.539 0.844 -2.487
ENSG00000112787 E021 17.1164443 0.0011498258 9.033948e-17 3.915475e-15 12 132560043 132560046 4 + 1.549 0.888 -2.354
ENSG00000112787 E022 18.8652341 0.0056198983 6.990772e-15 2.358228e-13 12 132560047 132560052 6 + 1.579 0.943 -2.252
ENSG00000112787 E023 70.3017773 0.0196981796 1.151547e-05 7.544776e-05 12 132560053 132560152 100 + 1.998 1.699 -1.009
ENSG00000112787 E024 86.9694179 0.0191267298 7.546685e-04 3.096325e-03 12 132560153 132560230 78 + 2.037 1.835 -0.681
ENSG00000112787 E025 100.1986136 0.0171073999 8.789905e-04 3.540457e-03 12 132567481 132567526 46 + 2.091 1.903 -0.630
ENSG00000112787 E026 222.5049038 0.0134262228 3.374635e-03 1.136357e-02 12 132569926 132570241 316 + 2.396 2.276 -0.401
ENSG00000112787 E027 45.4540862 0.0104377954 1.782462e-03 6.543847e-03 12 132570335 132570337 3 + 1.744 1.563 -0.615
ENSG00000112787 E028 265.0552586 0.0049728667 2.168237e-03 7.744602e-03 12 132570338 132570540 203 + 2.444 2.367 -0.256
ENSG00000112787 E029 141.9156017 0.0035421488 3.289574e-04 1.496638e-03 12 132571068 132571136 69 + 2.189 2.082 -0.356
ENSG00000112787 E030 97.3501434 0.0026916387 8.389220e-05 4.464738e-04 12 132571137 132571151 15 + 2.040 1.908 -0.446
ENSG00000112787 E031 157.6155695 0.0036911814 5.094581e-04 2.194877e-03 12 132571152 132571231 80 + 2.229 2.131 -0.327
ENSG00000112787 E032 206.8159724 0.0002281287 2.966791e-01 4.379406e-01 12 132571307 132571524 218 + 2.276 2.285 0.032
ENSG00000112787 E033 31.7807991 0.0006633305 2.888198e-17 1.328382e-15 12 132571861 132571922 62 + 1.747 1.260 -1.672
ENSG00000112787 E034 83.9634728 0.0003030324 1.126022e-37 3.348846e-35 12 132571923 132572287 365 + 2.149 1.687 -1.553
ENSG00000112787 E035 279.2627565 0.0003020675 3.358252e-02 7.893335e-02 12 132572288 132572338 51 + 2.422 2.410 -0.040
ENSG00000112787 E036 168.8865746 0.0032351726 3.544205e-01 4.987143e-01 12 132572339 132572344 6 + 2.199 2.202 0.008
ENSG00000112787 E037 358.5705176 0.0001601443 1.183951e-01 2.176299e-01 12 132572527 132572622 96 + 2.516 2.522 0.019
ENSG00000112787 E038 297.8054832 0.0001614832 4.874797e-01 6.251629e-01 12 132574090 132574158 69 + 2.426 2.448 0.073
ENSG00000112787 E039 257.0759775 0.0002548716 4.782032e-01 6.166458e-01 12 132574319 132574348 30 + 2.366 2.386 0.067
ENSG00000112787 E040 19.0245327 0.0603863146 5.185356e-01 6.527633e-01 12 132574349 132574492 144 + 1.275 1.258 -0.060
ENSG00000112787 E041 209.9798297 0.0002445315 7.532647e-01 8.392758e-01 12 132574493 132574495 3 + 2.272 2.301 0.096
ENSG00000112787 E042 369.6857315 0.0001766176 5.044740e-01 6.403852e-01 12 132574496 132574564 69 + 2.518 2.542 0.080
ENSG00000112787 E043 540.3937095 0.0001241347 2.280184e-01 3.600604e-01 12 132576799 132576931 133 + 2.686 2.704 0.059
ENSG00000112787 E044 96.5567848 0.0015050472 1.728384e-03 6.372413e-03 12 132581313 132581438 126 + 2.016 1.925 -0.306
ENSG00000112787 E045 509.8691932 0.0001707727 6.037924e-01 7.244865e-01 12 132581439 132581516 78 + 2.641 2.688 0.156
ENSG00000112787 E046 457.9500262 0.0003750295 3.436884e-01 4.877464e-01 12 132581741 132581824 84 + 2.587 2.644 0.191
ENSG00000112787 E047 602.2011298 0.0002323207 5.181120e-01 6.523885e-01 12 132582062 132582266 205 + 2.726 2.754 0.093
ENSG00000112787 E048 2.2036868 0.0070985468 9.734057e-02 1.864181e-01 12 132582267 132582267 1 + 0.643 0.397 -1.185
ENSG00000112787 E049 1632.7854136 0.0010553777 6.381175e-01 7.518468e-01 12 132582971 132585188 2218 + 3.158 3.195 0.121