ENSG00000112759

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371755 ENSG00000112759 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC29A1 protein_coding protein_coding 111.0415 136.594 73.96935 6.90506 1.134936 -0.8848052 47.990691 63.423807 27.895354 4.1334535 1.4266507 -1.18470997 0.42478333 0.46363333 0.37703333 -0.08660000 1.625704e-02 2.155704e-12 FALSE  
ENST00000472176 ENSG00000112759 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC29A1 protein_coding retained_intron 111.0415 136.594 73.96935 6.90506 1.134936 -0.8848052 7.947233 4.152510 6.122971 0.3844747 0.8292286 0.55913256 0.07509167 0.03026667 0.08253333 0.05226667 2.325907e-06 2.155704e-12 TRUE  
MSTRG.28355.7 ENSG00000112759 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC29A1 protein_coding   111.0415 136.594 73.96935 6.90506 1.134936 -0.8848052 7.332695 10.630947 3.751086 1.4316190 1.1460390 -1.50040542 0.06442917 0.07760000 0.05070000 -0.02690000 4.683355e-01 2.155704e-12 FALSE  
MSTRG.28355.8 ENSG00000112759 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC29A1 protein_coding   111.0415 136.594 73.96935 6.90506 1.134936 -0.8848052 6.752514 6.436905 6.274096 0.6991351 0.4565064 -0.03690133 0.06316250 0.04713333 0.08473333 0.03760000 1.707117e-03 2.155704e-12 FALSE  
MSTRG.28355.9 ENSG00000112759 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC29A1 protein_coding   111.0415 136.594 73.96935 6.90506 1.134936 -0.8848052 27.283186 37.967662 18.604506 0.3530365 0.5607604 -1.02872379 0.24555417 0.27930000 0.25173333 -0.02756667 5.557821e-01 2.155704e-12 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112759 E001 4.0052376 0.2681038470 9.828521e-01 9.933335e-01 6 44219553 44219614 62 + 0.707 0.642 -0.276
ENSG00000112759 E002 4.4491747 0.1355631592 4.492936e-01 5.904851e-01 6 44219615 44219627 13 + 0.810 0.638 -0.709
ENSG00000112759 E003 4.9672063 0.1101634228 6.174729e-01 7.352738e-01 6 44219628 44219629 2 + 0.810 0.701 -0.441
ENSG00000112759 E004 6.0690622 0.0115768869 2.986846e-01 4.401404e-01 6 44219630 44219635 6 + 0.894 0.770 -0.484
ENSG00000112759 E005 18.1727818 0.0046633068 2.395226e-01 3.735581e-01 6 44219636 44219782 147 + 1.304 1.219 -0.299
ENSG00000112759 E006 0.4751703 0.0220756035 1.000000e+00 1.000000e+00 6 44221586 44221685 100 + 0.163 0.166 0.026
ENSG00000112759 E007 0.0000000       6 44223535 44223537 3 +      
ENSG00000112759 E008 1.9478708 0.0100484330 3.928376e-01 5.367262e-01 6 44223538 44223558 21 + 0.516 0.380 -0.706
ENSG00000112759 E009 1.9478708 0.0100484330 3.928376e-01 5.367262e-01 6 44223559 44223560 2 + 0.516 0.380 -0.706
ENSG00000112759 E010 91.9038392 0.0019472732 7.879436e-01 8.641714e-01 6 44223561 44223594 34 + 1.907 1.939 0.107
ENSG00000112759 E011 102.4990726 0.0006316462 5.391220e-01 6.704130e-01 6 44223595 44223600 6 + 1.979 1.975 -0.015
ENSG00000112759 E012 193.5840923 0.0002861682 2.639399e-11 5.130579e-10 6 44223601 44223613 13 + 2.352 2.190 -0.540
ENSG00000112759 E013 251.4212260 0.0007557078 9.642198e-09 1.192976e-07 6 44223614 44223641 28 + 2.447 2.316 -0.439
ENSG00000112759 E014 1.7058162 0.0079101353 9.417048e-04 3.760210e-03 6 44223773 44223791 19 + 0.708 0.166 -3.143
ENSG00000112759 E015 1.7360052 0.0079718969 7.544696e-03 2.263050e-02 6 44223792 44223793 2 + 0.667 0.230 -2.388
ENSG00000112759 E016 2.5904788 0.0058466697 1.664639e-02 4.416077e-02 6 44223794 44223799 6 + 0.745 0.379 -1.710
ENSG00000112759 E017 3.6287331 0.0122876772 4.444267e-02 9.918982e-02 6 44223800 44223820 21 + 0.811 0.522 -1.235
ENSG00000112759 E018 12.1050781 0.0014592371 5.018793e-01 6.380259e-01 6 44223821 44223925 105 + 1.109 1.059 -0.181
ENSG00000112759 E019 5.9616783 0.0027213110 6.755518e-01 7.807922e-01 6 44223926 44223955 30 + 0.745 0.818 0.291
ENSG00000112759 E020 4.7501700 0.0978625306 6.488100e-02 1.348419e-01 6 44225697 44225924 228 + 0.919 0.607 -1.261
ENSG00000112759 E021 3.0625166 0.0052409096 3.319491e-04 1.508401e-03 6 44225925 44225972 48 + 0.868 0.335 -2.457
ENSG00000112759 E022 5.6295975 0.0108884286 3.377027e-03 1.137023e-02 6 44225973 44226060 88 + 1.005 0.630 -1.482
ENSG00000112759 E023 120.7718175 0.0019303369 5.478836e-08 5.854527e-07 6 44226061 44226167 107 + 2.167 1.975 -0.643
ENSG00000112759 E024 1.1134841 0.0111936316 1.913349e-01 3.154097e-01 6 44226628 44226753 126 + 0.451 0.230 -1.389
ENSG00000112759 E025 1.1855894 0.0176320238 3.795684e-01 5.238365e-01 6 44226754 44226790 37 + 0.163 0.336 1.354
ENSG00000112759 E026 2.2562123 0.0098949042 3.274796e-01 4.709421e-01 6 44226791 44227003 213 + 0.572 0.420 -0.748
ENSG00000112759 E027 1.1071545 0.0121444669 1.920274e-01 3.162938e-01 6 44227004 44227039 36 + 0.451 0.230 -1.389
ENSG00000112759 E028 5.0145640 0.0033359465 5.538013e-02 1.186430e-01 6 44227139 44227259 121 + 0.894 0.652 -0.972
ENSG00000112759 E029 85.1945838 0.0006839528 1.557697e-07 1.524755e-06 6 44227260 44227262 3 + 2.019 1.825 -0.653
ENSG00000112759 E030 471.1447754 0.0009873831 1.209233e-06 9.868425e-06 6 44227263 44227342 80 + 2.692 2.603 -0.293
ENSG00000112759 E031 457.6227690 0.0001880734 7.771096e-03 2.320415e-02 6 44229390 44229471 82 + 2.640 2.610 -0.099
ENSG00000112759 E032 772.6539646 0.0001348244 3.003940e-07 2.779426e-06 6 44229589 44229770 182 + 2.882 2.830 -0.175
ENSG00000112759 E033 407.9813228 0.0001316276 2.168057e-05 1.333026e-04 6 44229771 44229791 21 + 2.611 2.550 -0.203
ENSG00000112759 E034 695.8635659 0.0001881048 4.679814e-05 2.655455e-04 6 44229907 44230046 140 + 2.830 2.787 -0.141
ENSG00000112759 E035 70.6099931 0.0127216253 2.329118e-06 1.786126e-05 6 44230047 44230346 300 + 2.006 1.697 -1.045
ENSG00000112759 E036 362.9561068 0.0001899223 5.650558e-01 6.922230e-01 6 44230347 44230366 20 + 2.512 2.520 0.025
ENSG00000112759 E037 561.3284185 0.0007676308 5.754714e-01 7.010747e-01 6 44230367 44230481 115 + 2.700 2.710 0.032
ENSG00000112759 E038 762.1529315 0.0001351225 4.538748e-03 1.465025e-02 6 44230568 44230665 98 + 2.855 2.834 -0.070
ENSG00000112759 E039 869.6876183 0.0003910739 2.148336e-01 3.442523e-01 6 44230811 44230889 79 + 2.896 2.897 0.005
ENSG00000112759 E040 944.4829477 0.0003306714 3.153502e-01 4.581172e-01 6 44231364 44231461 98 + 2.907 2.943 0.118
ENSG00000112759 E041 714.2864694 0.0001184380 4.542990e-01 5.949454e-01 6 44231998 44232055 58 + 2.790 2.821 0.102
ENSG00000112759 E042 681.1796456 0.0001225456 6.532739e-04 2.727450e-03 6 44232056 44232106 51 + 2.739 2.811 0.240
ENSG00000112759 E043 685.9462920 0.0006146209 8.385225e-11 1.499203e-09 6 44232343 44232428 86 + 2.690 2.834 0.479
ENSG00000112759 E044 62.0010398 0.0023379905 5.965908e-08 6.329301e-07 6 44232429 44232806 378 + 1.917 1.663 -0.859
ENSG00000112759 E045 1039.2273860 0.0007889175 1.525070e-12 3.626004e-11 6 44232807 44233006 200 + 2.868 3.015 0.488
ENSG00000112759 E046 2436.3166117 0.0023119306 1.410710e-05 9.051201e-05 6 44233417 44234142 726 + 3.263 3.378 0.382
ENSG00000112759 E047 5.9903547 0.0028585738 2.140399e-05 1.317731e-04 6 44238665 44238902 238 + 1.093 0.579 -2.031
ENSG00000112759 E048 3.3266447 0.0048884347 8.340236e-01 8.960606e-01 6 44242184 44242323 140 + 0.622 0.604 -0.081