ENSG00000112739

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337659 ENSG00000112739 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF4B protein_coding protein_coding 29.95052 8.380341 47.48119 0.375062 1.068169 2.500859 5.0338773 1.327629396 7.42696442 0.219693939 0.20376979 2.475035 0.17568333 0.156833333 0.1567666667 -6.666667e-05 1.000000e+00 4.965077e-21 FALSE TRUE
ENST00000461612 ENSG00000112739 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF4B protein_coding processed_transcript 29.95052 8.380341 47.48119 0.375062 1.068169 2.500859 1.2303428 0.789519789 1.56732799 0.603137654 0.21150807 0.980277 0.05708333 0.093333333 0.0332333333 -6.010000e-02 9.609045e-01 4.965077e-21   FALSE
ENST00000463634 ENSG00000112739 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF4B protein_coding retained_intron 29.95052 8.380341 47.48119 0.375062 1.068169 2.500859 0.1649041 0.451816233 0.01928155 0.149105398 0.01928155 -3.979255 0.01627500 0.055566667 0.0004333333 -5.513333e-02 1.829835e-07 4.965077e-21 TRUE TRUE
ENST00000480058 ENSG00000112739 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF4B protein_coding nonsense_mediated_decay 29.95052 8.380341 47.48119 0.375062 1.068169 2.500859 5.1558915 2.780404326 8.46179616 0.324250770 0.48123416 1.602194 0.20922917 0.332100000 0.1785000000 -1.536000e-01 3.538443e-03 4.965077e-21 TRUE TRUE
ENST00000481109 ENSG00000112739 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF4B protein_coding nonsense_mediated_decay 29.95052 8.380341 47.48119 0.375062 1.068169 2.500859 0.4597196 1.257217980 0.00000000 0.338881978 0.00000000 -6.985521 0.05082500 0.148200000 0.0000000000 -1.482000e-01 4.965077e-21 4.965077e-21 TRUE TRUE
MSTRG.27573.11 ENSG00000112739 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF4B protein_coding   29.95052 8.380341 47.48119 0.375062 1.068169 2.500859 1.5055540 0.744025618 2.07825599 0.170061288 0.30305976 1.469613 0.06392083 0.089400000 0.0435333333 -4.586667e-02 1.578485e-01 4.965077e-21 TRUE TRUE
MSTRG.27573.12 ENSG00000112739 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF4B protein_coding   29.95052 8.380341 47.48119 0.375062 1.068169 2.500859 1.3076928 0.025721994 3.68333563 0.025721994 2.11012013 6.691968 0.03062500 0.002966667 0.0796333333 7.666667e-02 5.086489e-01 4.965077e-21 TRUE TRUE
MSTRG.27573.14 ENSG00000112739 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF4B protein_coding   29.95052 8.380341 47.48119 0.375062 1.068169 2.500859 5.1115198 0.000000000 6.77438026 0.000000000 3.45074223 9.406073 0.11642083 0.000000000 0.1449666667 1.449667e-01 3.251671e-01 4.965077e-21 TRUE TRUE
MSTRG.27573.15 ENSG00000112739 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF4B protein_coding   29.95052 8.380341 47.48119 0.375062 1.068169 2.500859 2.0913016 0.009657937 3.25911497 0.009657937 2.05827800 7.377644 0.04317500 0.001133333 0.0668333333 6.570000e-02 4.320054e-01 4.965077e-21 TRUE TRUE
MSTRG.27573.17 ENSG00000112739 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF4B protein_coding   29.95052 8.380341 47.48119 0.375062 1.068169 2.500859 1.4992203 0.000000000 7.03327408 0.000000000 5.09532044 9.460102 0.02900000 0.000000000 0.1445000000 1.445000e-01 2.250788e-03 4.965077e-21 TRUE TRUE
MSTRG.27573.7 ENSG00000112739 HEK293_OSMI2_2hA HEK293_TMG_2hB PRPF4B protein_coding   29.95052 8.380341 47.48119 0.375062 1.068169 2.500859 3.5439341 0.585397583 3.38802464 0.332314306 1.70709577 2.512771 0.11676667 0.073000000 0.0725666667 -4.333333e-04 1.000000e+00 4.965077e-21 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112739 E001 0.2214452 0.0382166478 8.720033e-02   6 4020977 4021105 129 + 0.000 0.227 15.060
ENSG00000112739 E002 0.2924217 0.0272950323 1.000000e+00   6 4021106 4021257 152 + 0.117 0.000 -12.113
ENSG00000112739 E003 0.2924217 0.0272950323 1.000000e+00   6 4021258 4021266 9 + 0.117 0.000 -12.113
ENSG00000112739 E004 0.2924217 0.0272950323 1.000000e+00   6 4021267 4021277 11 + 0.117 0.000 -12.113
ENSG00000112739 E005 0.4439371 0.0215576279 7.296492e-01 8.217967e-01 6 4021278 4021288 11 + 0.166 0.000 -12.699
ENSG00000112739 E006 0.5954526 0.0183678033 4.983468e-01 6.348149e-01 6 4021289 4021290 2 + 0.209 0.000 -13.114
ENSG00000112739 E007 1.4833268 0.0089954163 9.689629e-02 1.857440e-01 6 4021291 4021293 3 + 0.406 0.000 -14.436
ENSG00000112739 E008 1.6305759 0.0083867667 7.626190e-02 1.535230e-01 6 4021294 4021296 3 + 0.432 0.000 -14.573
ENSG00000112739 E009 2.3732775 0.0064326127 2.430499e-02 6.044405e-02 6 4021297 4021298 2 + 0.541 0.000 -15.114
ENSG00000112739 E010 2.5184501 0.0058576352 1.944378e-02 5.029764e-02 6 4021299 4021299 1 + 0.560 0.000 -15.201
ENSG00000112739 E011 2.6656992 0.0057313360 1.561125e-02 4.186905e-02 6 4021300 4021301 2 + 0.578 0.000 -15.283
ENSG00000112739 E012 6.9504321 0.0023466061 6.009116e-03 1.863517e-02 6 4021302 4021316 15 + 0.892 0.375 -2.312
ENSG00000112739 E013 102.2773196 0.0035039826 2.007043e-13 5.465406e-12 6 4021317 4021466 150 + 1.996 1.504 -1.667
ENSG00000112739 E014 898.8640028 0.0275866267 3.457151e-06 2.553997e-05 6 4031559 4032755 1197 + 2.925 2.559 -1.218
ENSG00000112739 E015 135.3342850 0.0002210879 3.761787e-18 1.929235e-16 6 4037397 4037418 22 + 2.112 1.683 -1.444
ENSG00000112739 E016 239.5259962 0.0038984101 9.155360e-15 3.028559e-13 6 4037419 4037570 152 + 2.354 1.969 -1.288
ENSG00000112739 E017 189.7064905 0.0097056706 1.715269e-06 1.353743e-05 6 4040772 4040847 76 + 2.246 1.927 -1.067
ENSG00000112739 E018 102.2513651 0.0085801310 9.721533e-05 5.090001e-04 6 4040848 4040848 1 + 1.977 1.685 -0.983
ENSG00000112739 E019 168.0277046 0.0125538296 1.751342e-04 8.574846e-04 6 4040849 4040927 79 + 2.188 1.911 -0.926
ENSG00000112739 E020 169.9737411 0.0252241161 3.281819e-02 7.744626e-02 6 4042487 4042568 82 + 2.182 1.983 -0.666
ENSG00000112739 E021 267.6086780 0.0183577851 5.949488e-03 1.847483e-02 6 4043813 4044023 211 + 2.380 2.170 -0.700
ENSG00000112739 E022 0.4396707 0.0299019947 7.312227e-01 8.229252e-01 6 4044024 4044226 203 + 0.165 0.000 -12.698
ENSG00000112739 E023 137.3706462 0.0058966488 1.111026e-02 3.143144e-02 6 4047175 4047248 74 + 2.082 1.924 -0.531
ENSG00000112739 E024 166.1998099 0.0047226226 5.391173e-04 2.306605e-03 6 4049016 4049106 91 + 2.170 1.977 -0.647
ENSG00000112739 E025 207.8853781 0.0063339222 1.026310e-02 2.941382e-02 6 4049732 4049879 148 + 2.261 2.111 -0.501
ENSG00000112739 E026 94.3280621 0.0163035064 1.886406e-01 3.120271e-01 6 4051957 4051981 25 + 1.916 1.793 -0.415
ENSG00000112739 E027 155.8348122 0.0011458341 1.732934e-01 2.924845e-01 6 4051982 4052094 113 + 2.124 2.050 -0.248
ENSG00000112739 E028 178.1324584 0.0022979622 4.807739e-01 6.190030e-01 6 4052720 4052873 154 + 2.178 2.129 -0.163
ENSG00000112739 E029 164.8025822 0.0003102682 3.772442e-01 5.215789e-01 6 4056321 4056435 115 + 2.145 2.094 -0.171
ENSG00000112739 E030 3.8470393 0.0040282016 3.045624e-02 7.285523e-02 6 4056436 4056526 91 + 0.687 0.226 -2.498
ENSG00000112739 E031 5.9251343 0.1491734766 7.568930e-01 8.418884e-01 6 4056527 4056688 162 + 0.785 0.708 -0.310
ENSG00000112739 E032 5.4754251 0.0034305153 4.182059e-03 1.365549e-02 6 4056689 4057035 347 + 0.817 0.226 -3.024
ENSG00000112739 E033 182.9343973 0.0002150387 5.436866e-01 6.742545e-01 6 4057036 4057159 124 + 2.186 2.146 -0.133
ENSG00000112739 E034 103.6257959 0.0008852981 5.308362e-01 6.633684e-01 6 4057160 4057187 28 + 1.943 1.894 -0.162
ENSG00000112739 E035 159.0417601 0.0012235125 1.117784e-01 2.081699e-01 6 4058728 4058814 87 + 2.108 2.149 0.136
ENSG00000112739 E036 2.4283568 0.0060877493 9.176663e-01 9.519668e-01 6 4058815 4058890 76 + 0.479 0.485 0.031
ENSG00000112739 E037 255.3169238 0.0001804816 3.693970e-02 8.534704e-02 6 4060413 4060644 232 + 2.313 2.351 0.125
ENSG00000112739 E038 84.5819274 0.0003010928 9.744659e-05 5.100700e-04 6 4060645 4060686 42 + 1.809 1.964 0.522
ENSG00000112739 E039 222.8933217 0.0002461890 1.475716e-03 5.558603e-03 6 4060687 4060981 295 + 2.248 2.320 0.242
ENSG00000112739 E040 96.7348996 0.0003018423 8.150320e-01 8.828209e-01 6 4060982 4061014 33 + 1.907 1.898 -0.029
ENSG00000112739 E041 180.8678780 0.0002353300 1.100510e-05 7.241947e-05 6 4061015 4061147 133 + 2.146 2.264 0.397
ENSG00000112739 E042 336.3976666 0.0310159893 1.901993e-03 6.920843e-03 6 4061148 4061654 507 + 2.371 2.638 0.888
ENSG00000112739 E043 142.9350847 0.0348875073 1.344604e-07 1.332694e-06 6 4061655 4061700 46 + 1.904 2.416 1.712
ENSG00000112739 E044 155.2266905 0.0244508357 3.147778e-08 3.527579e-07 6 4061701 4062103 403 + 1.968 2.416 1.496
ENSG00000112739 E045 61.9787433 0.0004139210 1.554911e-05 9.887332e-05 6 4062104 4062212 109 + 1.660 1.863 0.686
ENSG00000112739 E046 51.5680494 0.0017261192 6.368800e-09 8.151815e-08 6 4062213 4062214 2 + 1.544 1.855 1.053
ENSG00000112739 E047 57.1653711 0.0008076658 7.361221e-10 1.119410e-08 6 4062215 4062220 6 + 1.590 1.895 1.031
ENSG00000112739 E048 90.5698153 0.0006907027 2.139808e-14 6.706042e-13 6 4062221 4062299 79 + 1.788 2.092 1.024
ENSG00000112739 E049 32.9706649 0.0006201603 3.651358e-02 8.455844e-02 6 4062300 4062556 257 + 1.480 1.290 -0.661
ENSG00000112739 E050 71.0753849 0.0027605085 4.207863e-09 5.553235e-08 6 4062557 4062633 77 + 1.695 1.982 0.969
ENSG00000112739 E051 35.8880281 0.0024248199 7.716605e-01 8.526096e-01 6 4062634 4062760 127 + 1.494 1.453 -0.139
ENSG00000112739 E052 46.6500060 0.0062691448 1.225414e-01 2.235790e-01 6 4062761 4063073 313 + 1.570 1.665 0.323
ENSG00000112739 E053 62.4201187 0.0022016959 2.624702e-24 2.681995e-22 6 4063074 4063119 46 + 1.546 2.050 1.701
ENSG00000112739 E054 311.0485376 0.0097038511 8.530254e-03 2.511393e-02 6 4063120 4064800 1681 + 2.379 2.506 0.425
ENSG00000112739 E055 67.3242236 0.0050396331 1.621044e-27 2.210251e-25 6 4064801 4064983 183 + 1.543 2.128 1.977