ENSG00000112715

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000230480 ENSG00000112715 HEK293_OSMI2_2hA HEK293_TMG_2hB VEGFA protein_coding protein_coding 17.94828 14.72736 16.4554 0.6002388 0.4062521 0.1599589 2.4785515 2.051145 1.203850 0.1476232 0.1317523 -0.76385500 0.13846250 0.13920000 0.07306667 -0.066133333 0.003653808 0.003653808 FALSE  
ENST00000372077 ENSG00000112715 HEK293_OSMI2_2hA HEK293_TMG_2hB VEGFA protein_coding protein_coding 17.94828 14.72736 16.4554 0.6002388 0.4062521 0.1599589 2.0471641 1.886397 2.316494 0.1391159 0.1741255 0.29489648 0.11566250 0.12773333 0.14073333 0.013000000 0.793958387 0.003653808 FALSE  
ENST00000425836 ENSG00000112715 HEK293_OSMI2_2hA HEK293_TMG_2hB VEGFA protein_coding protein_coding 17.94828 14.72736 16.4554 0.6002388 0.4062521 0.1599589 3.3759404 2.185903 3.525351 0.7226736 0.3013836 0.68703926 0.19128333 0.14993333 0.21536667 0.065433333 0.616765627 0.003653808 FALSE  
ENST00000476772 ENSG00000112715 HEK293_OSMI2_2hA HEK293_TMG_2hB VEGFA protein_coding retained_intron 17.94828 14.72736 16.4554 0.6002388 0.4062521 0.1599589 1.2831058 1.359592 1.486390 0.3604251 0.3233227 0.12773960 0.07267083 0.09370000 0.09026667 -0.003433333 1.000000000 0.003653808 FALSE  
ENST00000493786 ENSG00000112715 HEK293_OSMI2_2hA HEK293_TMG_2hB VEGFA protein_coding retained_intron 17.94828 14.72736 16.4554 0.6002388 0.4062521 0.1599589 2.0705446 1.222303 1.668261 0.2496775 0.2599088 0.44560991 0.11176667 0.08463333 0.10193333 0.017300000 0.798950670 0.003653808    
ENST00000497139 ENSG00000112715 HEK293_OSMI2_2hA HEK293_TMG_2hB VEGFA protein_coding retained_intron 17.94828 14.72736 16.4554 0.6002388 0.4062521 0.1599589 2.1983408 2.094668 1.957373 0.2204845 0.1299892 -0.09732228 0.12587500 0.14166667 0.11883333 -0.022833333 0.572066743 0.003653808 TRUE  
ENST00000512683 ENSG00000112715 HEK293_OSMI2_2hA HEK293_TMG_2hB VEGFA protein_coding retained_intron 17.94828 14.72736 16.4554 0.6002388 0.4062521 0.1599589 2.3656235 1.471999 2.273834 0.5463462 0.3884119 0.62391337 0.12480000 0.09850000 0.13723333 0.038733333 0.617598814 0.003653808 FALSE  
ENST00000523950 ENSG00000112715 HEK293_OSMI2_2hA HEK293_TMG_2hB VEGFA protein_coding protein_coding 17.94828 14.72736 16.4554 0.6002388 0.4062521 0.1599589 0.1992208 1.141906 0.000000 1.1419060 0.0000000 -6.84787916 0.01425000 0.07530000 0.00000000 -0.075300000 0.785801414 0.003653808 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112715 E001 1.585547 0.0336912044 5.365520e-01 6.682938e-01 6 43770184 43770210 27 + 0.465 0.366 -0.533
ENSG00000112715 E002 1.730720 0.0342242324 3.813208e-01 5.256170e-01 6 43770211 43770212 2 + 0.510 0.366 -0.755
ENSG00000112715 E003 99.538089 0.0053361088 3.420361e-02 8.015252e-02 6 43770213 43770706 494 + 2.040 1.959 -0.270
ENSG00000112715 E004 28.877014 0.0173295019 7.452703e-01 8.333612e-01 6 43770707 43770781 75 + 1.473 1.465 -0.028
ENSG00000112715 E005 13.949491 0.0161057526 3.547580e-01 4.990779e-01 6 43770782 43770792 11 + 1.213 1.134 -0.280
ENSG00000112715 E006 47.673864 0.0203793428 7.108641e-02 1.451463e-01 6 43770793 43771082 290 + 1.747 1.618 -0.441
ENSG00000112715 E007 18.739386 0.0619229554 7.099197e-02 1.449854e-01 6 43771083 43771152 70 + 1.398 1.172 -0.792
ENSG00000112715 E008 26.247456 0.0188119276 5.154134e-02 1.118931e-01 6 43771153 43771208 56 + 1.514 1.348 -0.572
ENSG00000112715 E009 27.609670 0.0007538748 3.235065e-04 1.474849e-03 6 43771209 43771246 38 + 1.554 1.340 -0.737
ENSG00000112715 E010 45.805824 0.0005635583 1.165312e-04 5.979872e-04 6 43771247 43771312 66 + 1.753 1.578 -0.595
ENSG00000112715 E011 6.655543 0.0025005733 5.712125e-01 6.975523e-01 6 43771992 43772101 110 + 0.829 0.919 0.343
ENSG00000112715 E012 9.264362 0.0019088008 3.374016e-03 1.136189e-02 6 43773172 43774340 1169 + 0.786 1.134 1.302
ENSG00000112715 E013 43.673998 0.0090866719 2.676212e-02 6.549656e-02 6 43774341 43774352 12 + 1.709 1.583 -0.431
ENSG00000112715 E014 56.577458 0.0005268063 9.223589e-03 2.684304e-02 6 43774353 43774392 40 + 1.806 1.708 -0.330
ENSG00000112715 E015 5.609727 0.0030402397 9.113318e-01 9.476944e-01 6 43774393 43777468 3076 + 0.808 0.843 0.135
ENSG00000112715 E016 118.811583 0.0051194033 2.763164e-01 4.157650e-01 6 43777469 43777665 197 + 2.092 2.066 -0.088
ENSG00000112715 E017 9.608552 0.0076722782 1.253596e-01 2.276553e-01 6 43777666 43777719 54 + 1.086 0.937 -0.547
ENSG00000112715 E018 41.721571 0.0096404789 5.198862e-01 6.539448e-01 6 43777720 43778171 452 + 1.635 1.611 -0.082
ENSG00000112715 E019 33.585488 0.0006367532 6.441072e-02 1.340566e-01 6 43778172 43778459 288 + 1.577 1.489 -0.299
ENSG00000112715 E020 103.048676 0.0002800551 1.230028e-01 2.242416e-01 6 43778460 43778536 77 + 2.031 2.002 -0.097
ENSG00000112715 E021 7.746310 0.0680262194 9.280219e-02 1.795051e-01 6 43778537 43778764 228 + 0.763 1.066 1.150
ENSG00000112715 E022 69.958662 0.0003561989 8.449588e-02 1.665920e-01 6 43778889 43778918 30 + 1.876 1.828 -0.161
ENSG00000112715 E023 44.548684 0.0077817180 9.014114e-01 9.411671e-01 6 43778919 43780731 1813 + 1.642 1.670 0.096
ENSG00000112715 E024 8.060619 0.0062153533 7.489136e-01 8.360110e-01 6 43780732 43780785 54 + 0.954 0.937 -0.064
ENSG00000112715 E025 5.167109 0.0036407976 4.991805e-01 6.355168e-01 6 43780786 43780803 18 + 0.712 0.822 0.442
ENSG00000112715 E026 2.803287 0.0055296371 4.731628e-02 1.043956e-01 6 43780804 43780854 51 + 0.358 0.697 1.639
ENSG00000112715 E027 24.526196 0.0008218547 2.760276e-05 1.655930e-04 6 43780855 43781955 1101 + 1.204 1.529 1.128
ENSG00000112715 E028 40.341363 0.0005440612 7.518439e-02 1.518282e-01 6 43781956 43782010 55 + 1.542 1.664 0.413
ENSG00000112715 E029 37.383458 0.0008580386 5.192488e-01 6.533659e-01 6 43782011 43782052 42 + 1.550 1.610 0.205
ENSG00000112715 E030 36.635767 0.0028230619 7.267102e-01 8.196484e-01 6 43782053 43782087 35 + 1.573 1.574 0.003
ENSG00000112715 E031 54.700660 0.0004687146 6.163343e-10 9.509136e-09 6 43782088 43784540 2453 + 1.538 1.867 1.114
ENSG00000112715 E032 76.620263 0.0003414933 4.820026e-01 6.201666e-01 6 43784541 43784606 66 + 1.890 1.886 -0.014
ENSG00000112715 E033 541.098245 0.0071103046 3.985509e-03 1.310224e-02 6 43784607 43786487 1881 + 2.665 2.784 0.396