ENSG00000112701

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327284 ENSG00000112701 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP6 protein_coding protein_coding 15.33486 4.164252 26.49666 0.4342269 0.7455165 2.666765 0.8632914 0.0000000 2.2071397 0.00000000 0.03131910 7.7925558 0.03759167 0.0000 0.08336667 0.083366667 2.204870e-10 8.682945e-21 FALSE TRUE
ENST00000447266 ENSG00000112701 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP6 protein_coding protein_coding 15.33486 4.164252 26.49666 0.4342269 0.7455165 2.666765 3.7419774 0.7280931 7.7735810 0.16387461 0.32944844 3.3985594 0.22465417 0.1711 0.29433333 0.123233333 5.234445e-02 8.682945e-21 FALSE TRUE
ENST00000483859 ENSG00000112701 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP6 protein_coding protein_coding 15.33486 4.164252 26.49666 0.4342269 0.7455165 2.666765 3.7589677 0.0000000 7.2850526 0.00000000 0.43791838 9.5107746 0.14604583 0.0000 0.27573333 0.275733333 8.682945e-21 8.682945e-21 FALSE FALSE
ENST00000503501 ENSG00000112701 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP6 protein_coding nonsense_mediated_decay 15.33486 4.164252 26.49666 0.4342269 0.7455165 2.666765 0.2182735 0.2776784 0.1578008 0.07490292 0.01076027 -0.7777077 0.02580000 0.0644 0.00600000 -0.058400000 4.588549e-08 8.682945e-21 TRUE TRUE
MSTRG.28542.6 ENSG00000112701 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP6 protein_coding   15.33486 4.164252 26.49666 0.4342269 0.7455165 2.666765 0.8713134 1.2640044 0.8465561 0.13580093 0.84655606 -0.5727506 0.14081250 0.3158 0.03070000 -0.285100000 4.014097e-02 8.682945e-21 FALSE TRUE
MSTRG.28542.8 ENSG00000112701 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP6 protein_coding   15.33486 4.164252 26.49666 0.4342269 0.7455165 2.666765 2.2412228 0.8026891 2.7200220 0.02945042 0.64781538 1.7481371 0.15216250 0.1976 0.10340000 -0.094200000 1.991382e-01 8.682945e-21 FALSE TRUE
MSTRG.28542.9 ENSG00000112701 HEK293_OSMI2_2hA HEK293_TMG_2hB SENP6 protein_coding   15.33486 4.164252 26.49666 0.4342269 0.7455165 2.666765 1.3146076 0.2724385 1.4012942 0.27243851 0.70284903 2.3210100 0.09173750 0.0548 0.05346667 -0.001333333 7.819738e-01 8.682945e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112701 E001 1.8456903 0.0197500049 5.686069e-01 6.952380e-01 6 75601509 75601879 371 + 0.377 0.486 0.574
ENSG00000112701 E002 6.4248327 0.0024892132 7.932336e-01 8.677981e-01 6 75601880 75601926 47 + 0.805 0.765 -0.161
ENSG00000112701 E003 34.5720411 0.0005906265 9.092651e-07 7.615950e-06 6 75601927 75602149 223 + 1.531 1.080 -1.581
ENSG00000112701 E004 25.0290368 0.0007547239 5.046192e-05 2.841391e-04 6 75602150 75602206 57 + 1.393 0.967 -1.521
ENSG00000112701 E005 19.7897089 0.0009477777 4.791748e-05 2.712073e-04 6 75602207 75602223 17 + 1.303 0.813 -1.794
ENSG00000112701 E006 98.8890497 0.0008743157 2.325881e-15 8.380204e-14 6 75602224 75602576 353 + 1.976 1.523 -1.534
ENSG00000112701 E007 0.0000000       6 75620663 75620740 78 +      
ENSG00000112701 E008 73.5164079 0.0009095066 1.506884e-07 1.478683e-06 6 75621532 75621625 94 + 1.836 1.514 -1.093
ENSG00000112701 E009 16.3045346 0.0360006966 2.723082e-02 6.645793e-02 6 75622751 75622858 108 + 1.208 0.859 -1.279
ENSG00000112701 E010 78.3727368 0.0003703500 1.244436e-08 1.508057e-07 6 75623900 75623960 61 + 1.865 1.532 -1.131
ENSG00000112701 E011 80.8599297 0.0003187025 3.477381e-06 2.566940e-05 6 75633581 75633649 69 + 1.869 1.612 -0.870
ENSG00000112701 E012 68.1058802 0.0005028754 1.829394e-06 1.435264e-05 6 75633650 75633703 54 + 1.800 1.505 -1.002
ENSG00000112701 E013 53.1686792 0.0004178193 1.668203e-08 1.973129e-07 6 75633704 75633726 23 + 1.708 1.292 -1.429
ENSG00000112701 E014 91.1865920 0.0003376475 6.682175e-07 5.763158e-06 6 75634707 75634811 105 + 1.921 1.660 -0.880
ENSG00000112701 E015 0.8836079 0.0133925827 2.560434e-01 3.929989e-01 6 75634812 75635056 245 + 0.284 0.000 -9.972
ENSG00000112701 E016 19.0553075 0.0009380365 3.210267e-02 7.605636e-02 6 75640684 75640686 3 + 1.257 1.027 -0.826
ENSG00000112701 E017 41.9986400 0.0005457771 3.484401e-02 8.135034e-02 6 75640687 75640704 18 + 1.576 1.423 -0.525
ENSG00000112701 E018 1.1698006 0.1917113046 2.295191e-01 3.618591e-01 6 75646511 75646851 341 + 0.348 0.000 -10.530
ENSG00000112701 E019 2.4787068 0.0059139171 9.571930e-01 9.771805e-01 6 75647292 75647730 439 + 0.477 0.486 0.045
ENSG00000112701 E020 80.0919299 0.0004936135 4.939810e-02 1.080912e-01 6 75647731 75647801 71 + 1.841 1.738 -0.348
ENSG00000112701 E021 115.9423579 0.0033441594 8.985126e-04 3.609196e-03 6 75659262 75659407 146 + 2.011 1.837 -0.582
ENSG00000112701 E022 191.0347152 0.0023183575 5.608562e-09 7.255704e-08 6 75663221 75663518 298 + 2.237 1.990 -0.829
ENSG00000112701 E023 140.4211831 0.0058642524 6.821018e-05 3.715201e-04 6 75666712 75666870 159 + 2.101 1.880 -0.740
ENSG00000112701 E024 101.3195288 0.0003353351 9.778241e-07 8.128026e-06 6 75666871 75666941 71 + 1.963 1.721 -0.815
ENSG00000112701 E025 120.1850609 0.0002677033 1.083766e-02 3.077559e-02 6 75670553 75670720 168 + 2.016 1.908 -0.365
ENSG00000112701 E026 60.7701395 0.0004177146 2.037050e-02 5.226270e-02 6 75675435 75675468 34 + 1.729 1.589 -0.476
ENSG00000112701 E027 112.7636022 0.0005013630 8.002717e-01 8.726857e-01 6 75675860 75676054 195 + 1.969 1.957 -0.040
ENSG00000112701 E028 1.4186931 0.0640489265 5.853672e-01 7.090812e-01 6 75676604 75677029 426 + 0.349 0.228 -0.835
ENSG00000112701 E029 21.7969432 0.0120568785 7.263797e-03 2.191075e-02 6 75677030 75677035 6 + 1.202 1.458 0.893
ENSG00000112701 E030 70.8744183 0.0003924041 7.513771e-02 1.517517e-01 6 75677036 75677167 132 + 1.748 1.835 0.296
ENSG00000112701 E031 85.1792986 0.0024735455 7.318954e-01 8.234719e-01 6 75677168 75677256 89 + 1.852 1.832 -0.067
ENSG00000112701 E032 1.2523272 0.0104430333 2.041098e-01 3.313168e-01 6 75677257 75678582 1326 + 0.248 0.486 1.423
ENSG00000112701 E033 85.9017751 0.0008202786 2.716608e-01 4.104322e-01 6 75678583 75678692 110 + 1.838 1.889 0.172
ENSG00000112701 E034 93.5966885 0.0003233669 3.267649e-03 1.105440e-02 6 75678811 75678927 117 + 1.857 1.982 0.421
ENSG00000112701 E035 9.7892330 0.0017501597 2.727883e-01 4.117448e-01 6 75678928 75679867 940 + 0.924 1.054 0.482
ENSG00000112701 E036 105.4821787 0.0003785833 1.646079e-06 1.303917e-05 6 75695804 75695923 120 + 1.890 2.080 0.636
ENSG00000112701 E037 96.2586675 0.0012551404 1.107287e-06 9.104301e-06 6 75697425 75697517 93 + 1.846 2.057 0.709
ENSG00000112701 E038 3.5170497 0.0043478779 5.991453e-01 7.206016e-01 6 75697518 75697989 472 + 0.558 0.648 0.396
ENSG00000112701 E039 265.3390370 0.0008949923 9.245093e-04 3.700841e-03 6 75702645 75703072 428 + 2.315 2.408 0.311
ENSG00000112701 E040 151.1081970 0.0004360445 4.088492e-02 9.267857e-02 6 75709527 75709630 104 + 2.078 2.148 0.236
ENSG00000112701 E041 150.0446096 0.0002531656 2.569929e-03 8.973152e-03 6 75711328 75711416 89 + 2.065 2.167 0.342
ENSG00000112701 E042 126.3321046 0.0002521364 2.596509e-05 1.568461e-04 6 75713513 75713581 69 + 1.979 2.131 0.511
ENSG00000112701 E043 208.2391597 0.0013388920 2.559484e-13 6.868082e-12 6 75713675 75713825 151 + 2.171 2.402 0.769
ENSG00000112701 E044 306.8150893 0.0002611757 1.696220e-41 6.452685e-39 6 75715385 75718281 2897 + 2.316 2.616 1.001