ENSG00000112699

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380815 ENSG00000112699 HEK293_OSMI2_2hA HEK293_TMG_2hB GMDS protein_coding protein_coding 48.87965 73.38121 51.14654 2.987253 2.194962 -0.5206885 25.615088 27.299908 39.4380957 2.1407928 0.1084207 0.5305312 0.51573333 0.37323333 0.77406667 0.40083333 9.985124e-08 1.200925e-78 FALSE TRUE
ENST00000486793 ENSG00000112699 HEK293_OSMI2_2hA HEK293_TMG_2hB GMDS protein_coding processed_transcript 48.87965 73.38121 51.14654 2.987253 2.194962 -0.5206885 2.385783 6.570691 0.8429656 0.7491897 0.2905774 -2.9476795 0.04297917 0.09063333 0.01696667 -0.07366667 2.501783e-03 1.200925e-78   FALSE
ENST00000530927 ENSG00000112699 HEK293_OSMI2_2hA HEK293_TMG_2hB GMDS protein_coding protein_coding 48.87965 73.38121 51.14654 2.987253 2.194962 -0.5206885 12.597364 30.362819 0.0000000 2.6946504 0.0000000 -11.5685651 0.25530000 0.41270000 0.00000000 -0.41270000 1.200925e-78 1.200925e-78 FALSE TRUE
ENST00000531690 ENSG00000112699 HEK293_OSMI2_2hA HEK293_TMG_2hB GMDS protein_coding processed_transcript 48.87965 73.38121 51.14654 2.987253 2.194962 -0.5206885 6.746150 6.648588 9.8834638 1.8631396 2.0583010 0.5712594 0.15535000 0.08896667 0.19036667 0.10140000 1.249115e-01 1.200925e-78 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112699 E001 4.0252467 0.0051307876 2.043105e-02 5.239817e-02 6 1623806 1623806 1 - 0.422 0.789 1.651
ENSG00000112699 E002 576.4176985 0.0012128567 6.517421e-17 2.870741e-15 6 1623807 1624231 425 - 2.617 2.792 0.584
ENSG00000112699 E003 463.0894520 0.0002197820 5.290311e-11 9.780751e-10 6 1624472 1624540 69 - 2.569 2.683 0.378
ENSG00000112699 E004 28.2941722 0.0009608070 4.312244e-07 3.864070e-06 6 1624645 1624740 96 - 1.163 1.542 1.320
ENSG00000112699 E005 5.1982248 0.0801182293 4.869245e-02 1.068430e-01 6 1625097 1625501 405 - 0.484 0.862 1.614
ENSG00000112699 E006 25.0522641 0.0141779053 2.539532e-07 2.385732e-06 6 1626117 1626188 72 - 0.983 1.508 1.857
ENSG00000112699 E007 2.7111343 0.1332908616 7.860901e-01 8.630053e-01 6 1679172 1679926 755 - 0.538 0.578 0.180
ENSG00000112699 E008 0.8114974 0.0290802666 3.821106e-01 5.263520e-01 6 1717508 1717594 87 - 0.149 0.307 1.327
ENSG00000112699 E009 0.8104533 0.0147636182 9.557114e-01 9.762151e-01 6 1717595 1717643 49 - 0.260 0.249 -0.085
ENSG00000112699 E010 534.9288366 0.0001966515 1.843884e-05 1.153399e-04 6 1726416 1726512 97 - 2.666 2.732 0.220
ENSG00000112699 E011 565.3189838 0.0005926458 7.804895e-02 1.563397e-01 6 1742468 1742586 119 - 2.715 2.743 0.091
ENSG00000112699 E012 289.8991925 0.0012356177 3.002514e-01 4.419199e-01 6 1930103 1930106 4 - 2.465 2.434 -0.103
ENSG00000112699 E013 561.2396259 0.0012141000 6.622372e-01 7.705845e-01 6 1930107 1930230 124 - 2.739 2.725 -0.048
ENSG00000112699 E014 1.5437022 0.0089270595 7.386152e-01 8.284544e-01 6 1930231 1930999 769 - 0.422 0.360 -0.345
ENSG00000112699 E015 4.0199507 0.0102422657 2.852221e-01 4.255336e-01 6 1959706 1959866 161 - 0.588 0.750 0.688
ENSG00000112699 E016 468.8946585 0.0021762483 3.149896e-01 4.577373e-01 6 1959867 1959971 105 - 2.673 2.640 -0.109
ENSG00000112699 E017 597.0410480 0.0001131233 7.632181e-05 4.106253e-04 6 1960774 1960966 193 - 2.796 2.735 -0.206
ENSG00000112699 E018 0.0000000       6 2043336 2043433 98 -      
ENSG00000112699 E019 419.4123907 0.0005209108 2.476774e-04 1.165641e-03 6 2115771 2115880 110 - 2.652 2.574 -0.260
ENSG00000112699 E020 298.7925135 0.0029789187 3.940256e-05 2.274713e-04 6 2117469 2117556 88 - 2.543 2.401 -0.472
ENSG00000112699 E021 171.4576166 0.0026344125 3.135497e-05 1.856805e-04 6 2124687 2124731 45 - 2.311 2.153 -0.529
ENSG00000112699 E022 0.1482932 0.0410657449 7.230736e-01   6 2175932 2175991 60 - 0.000 0.100 8.446
ENSG00000112699 E023 201.2520639 0.0031239293 4.026046e-18 2.058074e-16 6 2245321 2245605 285 - 2.466 2.145 -1.072