ENSG00000112685

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000230449 ENSG00000112685 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC2 protein_coding protein_coding 16.77227 10.83024 22.17808 0.3031412 0.1372621 1.033389 8.320760 5.97810533 9.405721 0.62549103 0.8090634 0.652972 0.53217500 0.551133333 0.4239 -0.1272333 2.634760e-01 2.068075e-30 FALSE TRUE
ENST00000475028 ENSG00000112685 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC2 protein_coding processed_transcript 16.77227 10.83024 22.17808 0.3031412 0.1372621 1.033389 2.075386 4.40741301 1.359323 0.61216743 0.0630419 -1.689739 0.17127083 0.407033333 0.0613 -0.3457333 3.632820e-13 2.068075e-30   FALSE
MSTRG.27503.3 ENSG00000112685 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC2 protein_coding   16.77227 10.83024 22.17808 0.3031412 0.1372621 1.033389 1.577731 0.25308486 4.169445 0.13569644 0.7065094 3.989711 0.07585417 0.023933333 0.1880 0.1640667 4.768629e-04 2.068075e-30 FALSE TRUE
MSTRG.27503.5 ENSG00000112685 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC2 protein_coding   16.77227 10.83024 22.17808 0.3031412 0.1372621 1.033389 2.360550 0.05345597 5.072242 0.03092663 0.2469822 6.323565 0.10868750 0.005033333 0.2288 0.2237667 2.068075e-30 2.068075e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112685 E001 61.559290 0.0180909586 2.439395e-09 3.364513e-08 6 485154 485495 342 - 1.551 2.037 1.641
ENSG00000112685 E002 70.025833 0.0032208301 1.186146e-14 3.859039e-13 6 485496 485666 171 - 1.661 2.051 1.313
ENSG00000112685 E003 43.670492 0.0016927214 6.809231e-10 1.041994e-08 6 485667 485708 42 - 1.482 1.832 1.190
ENSG00000112685 E004 55.788355 0.0004352674 1.127360e-11 2.328047e-10 6 485709 485801 93 - 1.596 1.924 1.109
ENSG00000112685 E005 76.280465 0.0003331699 3.441131e-09 4.619230e-08 6 485802 485935 134 - 1.768 2.017 0.835
ENSG00000112685 E006 183.959152 0.0002141702 4.429229e-15 1.536258e-13 6 485936 486403 468 - 2.162 2.377 0.716
ENSG00000112685 E007 31.866472 0.0119857032 4.239920e-03 1.381324e-02 6 486404 486406 3 - 1.401 1.644 0.830
ENSG00000112685 E008 111.104882 0.0016802030 7.383942e-04 3.037061e-03 6 486407 486633 227 - 1.977 2.116 0.465
ENSG00000112685 E009 98.062694 0.0004023249 1.133770e-03 4.416805e-03 6 486634 486764 131 - 1.928 2.055 0.428
ENSG00000112685 E010 74.089071 0.0014004091 4.140564e-04 1.828308e-03 6 488979 489038 60 - 1.792 1.957 0.554
ENSG00000112685 E011 84.662618 0.0003321559 4.706461e-03 1.511485e-02 6 491125 491186 62 - 1.869 1.988 0.399
ENSG00000112685 E012 93.122395 0.0003305224 9.768219e-03 2.819213e-02 6 497367 497489 123 - 1.914 2.019 0.352
ENSG00000112685 E013 67.779895 0.0068899123 9.006848e-02 1.752427e-01 6 499645 499700 56 - 1.777 1.880 0.346
ENSG00000112685 E014 120.162157 0.0080780772 2.705611e-01 4.092194e-01 6 532469 532610 142 - 2.038 2.096 0.193
ENSG00000112685 E015 122.322359 0.0006111230 5.920758e-01 7.147034e-01 6 549175 549291 117 - 2.058 2.082 0.081
ENSG00000112685 E016 84.922213 0.0003608739 2.374434e-01 3.711990e-01 6 553854 553920 67 - 1.920 1.877 -0.147
ENSG00000112685 E017 72.912899 0.0003821355 9.204972e-02 1.783137e-01 6 555227 555288 62 - 1.863 1.792 -0.239
ENSG00000112685 E018 81.073028 0.0003169963 1.996576e-01 3.258067e-01 6 555954 556013 60 - 1.904 1.855 -0.164
ENSG00000112685 E019 94.276525 0.0003212674 2.912785e-03 1.000777e-02 6 556484 556564 81 - 1.990 1.876 -0.382
ENSG00000112685 E020 96.433014 0.0002934739 3.033914e-07 2.804694e-06 6 562784 562845 62 - 2.021 1.816 -0.688
ENSG00000112685 E021 115.616207 0.0002675421 1.965154e-04 9.490963e-04 6 564033 564154 122 - 2.080 1.950 -0.437
ENSG00000112685 E022 113.178316 0.0002925517 5.049020e-02 1.100361e-01 6 564545 564702 158 - 2.055 1.990 -0.217
ENSG00000112685 E023 82.730649 0.0009522014 3.440915e-01 4.881429e-01 6 564864 564929 66 - 1.910 1.873 -0.121
ENSG00000112685 E024 107.286340 0.0004861315 1.976803e-02 5.099531e-02 6 572520 572644 125 - 2.035 1.952 -0.279
ENSG00000112685 E025 101.871208 0.0003403175 1.105770e-03 4.322341e-03 6 576757 576882 126 - 2.024 1.902 -0.407
ENSG00000112685 E026 97.160985 0.0013438025 2.936679e-02 7.070984e-02 6 592469 592587 119 - 1.994 1.907 -0.291
ENSG00000112685 E027 87.012172 0.0003060873 2.791943e-03 9.649345e-03 6 598021 598123 103 - 1.956 1.836 -0.402
ENSG00000112685 E028 77.016240 0.0003239750 1.076410e-03 4.222846e-03 6 598860 598941 82 - 1.907 1.766 -0.476
ENSG00000112685 E029 108.929706 0.0013759092 6.674195e-08 7.015577e-07 6 599080 599225 146 - 2.077 1.852 -0.755
ENSG00000112685 E030 86.321787 0.0006772764 4.011730e-10 6.398197e-09 6 610098 610178 81 - 1.990 1.709 -0.947
ENSG00000112685 E031 98.973056 0.0023250561 3.400868e-11 6.487607e-10 6 617711 617835 125 - 2.056 1.742 -1.057
ENSG00000112685 E032 88.927419 0.0016215363 9.649494e-09 1.193723e-07 6 619430 619543 114 - 1.999 1.730 -0.906
ENSG00000112685 E033 79.707278 0.0059420832 3.920992e-06 2.856891e-05 6 629835 629961 127 - 1.953 1.678 -0.929
ENSG00000112685 E034 95.115550 0.0099757610 1.344604e-06 1.086320e-05 6 632941 633117 177 - 2.036 1.719 -1.069
ENSG00000112685 E035 91.331713 0.0121364023 1.234413e-07 1.231987e-06 6 637701 637861 161 - 2.030 1.651 -1.278
ENSG00000112685 E036 2.999961 0.0049578296 7.952041e-01 8.691959e-01 6 657163 657250 88 - 0.590 0.552 -0.176
ENSG00000112685 E037 31.506470 0.0260513553 3.271554e-18 1.690172e-16 6 679143 679514 372 - 0.967 1.866 3.132
ENSG00000112685 E038 22.182080 0.0262390600 2.952153e-05 1.759838e-04 6 689139 689212 74 - 1.140 1.583 1.541
ENSG00000112685 E039 64.224023 0.0049101479 6.312493e-01 7.462947e-01 6 693019 693139 121 - 1.776 1.804 0.094