ENSG00000112659

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000252050 ENSG00000112659 HEK293_OSMI2_2hA HEK293_TMG_2hB CUL9 protein_coding protein_coding 6.58329 7.303073 5.879766 0.4885279 0.2213276 -0.3122676 1.1704462 1.84113112 1.3079123 0.18199184 0.14540806 -0.4901528 0.19197083 0.25130000 0.22126667 -0.03003333 0.7388755 0.0223352 FALSE  
ENST00000504485 ENSG00000112659 HEK293_OSMI2_2hA HEK293_TMG_2hB CUL9 protein_coding retained_intron 6.58329 7.303073 5.879766 0.4885279 0.2213276 -0.3122676 0.4421981 0.37539391 0.4218671 0.13813351 0.12043643 0.1642536 0.06325417 0.05260000 0.07046667 0.01786667 0.7822055 0.0223352 FALSE  
ENST00000505172 ENSG00000112659 HEK293_OSMI2_2hA HEK293_TMG_2hB CUL9 protein_coding retained_intron 6.58329 7.303073 5.879766 0.4885279 0.2213276 -0.3122676 0.4120057 0.26017199 0.5644917 0.13013399 0.29661186 1.0884078 0.05807917 0.03680000 0.09600000 0.05920000 0.8552994 0.0223352 FALSE  
ENST00000505405 ENSG00000112659 HEK293_OSMI2_2hA HEK293_TMG_2hB CUL9 protein_coding retained_intron 6.58329 7.303073 5.879766 0.4885279 0.2213276 -0.3122676 0.3487115 0.28684290 0.3346145 0.28684290 0.05669581 0.2152839 0.05312917 0.03766667 0.05776667 0.02010000 0.3818270 0.0223352 FALSE  
ENST00000506830 ENSG00000112659 HEK293_OSMI2_2hA HEK293_TMG_2hB CUL9 protein_coding nonsense_mediated_decay 6.58329 7.303073 5.879766 0.4885279 0.2213276 -0.3122676 0.4352752 1.14633115 0.0000000 0.57396633 0.00000000 -6.8534108 0.06151667 0.16190000 0.00000000 -0.16190000 0.1766594 0.0223352 FALSE  
ENST00000508656 ENSG00000112659 HEK293_OSMI2_2hA HEK293_TMG_2hB CUL9 protein_coding retained_intron 6.58329 7.303073 5.879766 0.4885279 0.2213276 -0.3122676 0.5715464 0.76586851 0.5537291 0.11625480 0.12574982 -0.4608101 0.08197083 0.10660000 0.09390000 -0.01270000 0.8716232 0.0223352 FALSE  
ENST00000512408 ENSG00000112659 HEK293_OSMI2_2hA HEK293_TMG_2hB CUL9 protein_coding retained_intron 6.58329 7.303073 5.879766 0.4885279 0.2213276 -0.3122676 0.3484168 0.35308649 0.2127706 0.17743039 0.05372439 -0.7047541 0.05031250 0.04590000 0.03690000 -0.00900000 0.9370192 0.0223352    
ENST00000512423 ENSG00000112659 HEK293_OSMI2_2hA HEK293_TMG_2hB CUL9 protein_coding retained_intron 6.58329 7.303073 5.879766 0.4885279 0.2213276 -0.3122676 0.5013593 0.41326935 0.2393631 0.11820670 0.02817452 -0.7633278 0.07172083 0.05603333 0.04050000 -0.01553333 0.7471929 0.0223352    
MSTRG.28323.11 ENSG00000112659 HEK293_OSMI2_2hA HEK293_TMG_2hB CUL9 protein_coding   6.58329 7.303073 5.879766 0.4885279 0.2213276 -0.3122676 0.1044405 0.35652257 0.0000000 0.17910351 0.00000000 -5.1958301 0.01586250 0.05023333 0.00000000 -0.05023333 0.1698264 0.0223352 TRUE  
MSTRG.28323.7 ENSG00000112659 HEK293_OSMI2_2hA HEK293_TMG_2hB CUL9 protein_coding   6.58329 7.303073 5.879766 0.4885279 0.2213276 -0.3122676 0.1216159 0.00000000 0.4176251 0.00000000 0.20888537 5.4182746 0.02158750 0.00000000 0.06966667 0.06966667 0.1503531 0.0223352 FALSE  
MSTRG.28323.8 ENSG00000112659 HEK293_OSMI2_2hA HEK293_TMG_2hB CUL9 protein_coding   6.58329 7.303073 5.879766 0.4885279 0.2213276 -0.3122676 0.4841934 0.08592575 0.6058781 0.08592575 0.04522721 2.6826547 0.08277083 0.01080000 0.10386667 0.09306667 0.0223352 0.0223352 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112659 E001 0.5085815 0.2373178609 8.045531e-01 8.756415e-01 6 43182177 43182183 7 + 0.140 0.193 0.561
ENSG00000112659 E002 0.5085815 0.2373178609 8.045531e-01 8.756415e-01 6 43182184 43182184 1 + 0.140 0.193 0.561
ENSG00000112659 E003 0.5085815 0.2373178609 8.045531e-01 8.756415e-01 6 43182185 43182195 11 + 0.140 0.193 0.561
ENSG00000112659 E004 0.5085815 0.2373178609 8.045531e-01 8.756415e-01 6 43182196 43182198 3 + 0.140 0.193 0.561
ENSG00000112659 E005 0.8010032 0.1582441094 4.792037e-01 6.175888e-01 6 43182199 43182200 2 + 0.330 0.193 -1.026
ENSG00000112659 E006 1.2385976 0.2911179995 1.785897e-01 2.993858e-01 6 43182201 43182206 6 + 0.514 0.193 -2.018
ENSG00000112659 E007 3.7432269 0.0192006132 2.318987e-03 8.210918e-03 6 43182207 43182249 43 + 0.894 0.427 -2.031
ENSG00000112659 E008 1.3599346 0.1405067327 6.957221e-01 7.962495e-01 6 43183008 43183088 81 + 0.402 0.328 -0.430
ENSG00000112659 E009 41.8399540 0.0015992994 1.893994e-10 3.186320e-09 6 43184302 43184773 472 + 1.796 1.444 -1.201
ENSG00000112659 E010 18.0766683 0.0010290003 6.110440e-05 3.369370e-04 6 43184774 43184905 132 + 1.435 1.122 -1.098
ENSG00000112659 E011 9.3957015 0.0120578368 3.112387e-02 7.414335e-02 6 43185456 43185490 35 + 1.144 0.900 -0.895
ENSG00000112659 E012 17.2618508 0.0019136325 3.877840e-06 2.829912e-05 6 43185491 43185610 120 + 1.447 1.074 -1.314
ENSG00000112659 E013 45.2179388 0.0028026989 1.006993e-11 2.096162e-10 6 43185955 43186455 501 + 1.849 1.468 -1.292
ENSG00000112659 E014 0.3666179 0.0274841708 8.157221e-01 8.833771e-01 6 43186928 43186959 32 + 0.140 0.107 -0.446
ENSG00000112659 E015 18.3690728 0.0010019365 1.107661e-03 4.328715e-03 6 43186960 43187095 136 + 1.410 1.158 -0.886
ENSG00000112659 E016 22.0403706 0.0008963775 4.050701e-07 3.648693e-06 6 43187246 43187439 194 + 1.537 1.174 -1.264
ENSG00000112659 E017 10.6233396 0.0016832606 1.902594e-03 6.922897e-03 6 43187713 43187734 22 + 1.220 0.916 -1.106
ENSG00000112659 E018 26.2249514 0.0008230049 3.233774e-06 2.402151e-05 6 43187735 43187908 174 + 1.583 1.275 -1.063
ENSG00000112659 E019 34.8620414 0.0006151884 2.438136e-05 1.483150e-04 6 43187909 43188118 210 + 1.676 1.434 -0.825
ENSG00000112659 E020 4.0942366 0.0038943189 8.384583e-01 8.990192e-01 6 43188119 43188522 404 + 0.681 0.714 0.135
ENSG00000112659 E021 25.0957717 0.0012758468 9.365118e-02 1.808285e-01 6 43188523 43188715 193 + 1.464 1.352 -0.390
ENSG00000112659 E022 2.2799593 0.0066290289 5.555194e-01 6.843645e-01 6 43188716 43188958 243 + 0.564 0.470 -0.449
ENSG00000112659 E023 23.8270775 0.0014256613 7.372982e-03 2.218711e-02 6 43193001 43193208 208 + 1.481 1.294 -0.648
ENSG00000112659 E024 28.8773360 0.0007255861 1.277904e-03 4.903789e-03 6 43196069 43196265 197 + 1.574 1.372 -0.694
ENSG00000112659 E025 3.1573367 0.0063893005 1.746944e-01 2.943116e-01 6 43196266 43196644 379 + 0.714 0.509 -0.906
ENSG00000112659 E026 36.2533540 0.0071845267 2.033201e-03 7.329434e-03 6 43196645 43196862 218 + 1.669 1.460 -0.714
ENSG00000112659 E027 29.4791780 0.0019300435 2.357219e-03 8.330407e-03 6 43198609 43198855 247 + 1.574 1.378 -0.673
ENSG00000112659 E028 19.9499439 0.0028974948 1.810907e-01 3.025797e-01 6 43199266 43199371 106 + 1.370 1.268 -0.355
ENSG00000112659 E029 37.0326909 0.0043930452 1.451267e-01 2.550139e-01 6 43199929 43200156 228 + 1.620 1.530 -0.306
ENSG00000112659 E030 26.4777606 0.0007902937 1.058240e-02 3.016875e-02 6 43200436 43200526 91 + 1.518 1.351 -0.574
ENSG00000112659 E031 31.8670718 0.0362562011 1.139128e-01 2.112291e-01 6 43200663 43200834 172 + 1.588 1.430 -0.541
ENSG00000112659 E032 22.2757275 0.0084737533 3.494031e-02 8.154001e-02 6 43202716 43202821 106 + 1.447 1.277 -0.593
ENSG00000112659 E033 19.0591121 0.0030932451 2.797030e-01 4.194681e-01 6 43203109 43203204 96 + 1.333 1.249 -0.294
ENSG00000112659 E034 0.3332198 0.0284462511 8.159866e-01   6 43203273 43203416 144 + 0.140 0.107 -0.449
ENSG00000112659 E035 23.1356261 0.0008179026 8.601555e-01 9.137886e-01 6 43203417 43203592 176 + 1.355 1.372 0.059
ENSG00000112659 E036 24.6051266 0.0008441578 2.699101e-01 4.084648e-01 6 43203854 43203987 134 + 1.333 1.416 0.289
ENSG00000112659 E037 1.3985164 0.0293235465 8.026219e-01 8.742703e-01 6 43203988 43204132 145 + 0.330 0.380 0.293
ENSG00000112659 E038 2.5099253 0.0059845976 1.688814e-01 2.867239e-01 6 43204156 43204359 204 + 0.646 0.427 -1.032
ENSG00000112659 E039 33.5390944 0.0137545507 7.016733e-01 8.007343e-01 6 43204360 43204539 180 + 1.492 1.532 0.138
ENSG00000112659 E040 24.4695173 0.0199313483 6.181687e-01 7.358711e-01 6 43204748 43204857 110 + 1.348 1.405 0.199
ENSG00000112659 E041 29.6184541 0.0097181218 5.681512e-01 6.948468e-01 6 43204933 43205115 183 + 1.429 1.482 0.184
ENSG00000112659 E042 3.6169806 0.0055439847 2.845425e-02 6.892082e-02 6 43205172 43205262 91 + 0.826 0.509 -1.356
ENSG00000112659 E043 27.7019059 0.0480356733 5.544565e-01 6.834456e-01 6 43205263 43205423 161 + 1.390 1.472 0.283
ENSG00000112659 E044 17.9787350 0.0153651183 8.931084e-01 9.356837e-01 6 43206007 43206082 76 + 1.267 1.258 -0.031
ENSG00000112659 E045 26.7679125 0.0007229702 2.316379e-01 3.644080e-01 6 43206083 43206235 153 + 1.370 1.456 0.299
ENSG00000112659 E046 19.5528138 0.0010098269 2.483424e-01 3.839752e-01 6 43206321 43206353 33 + 1.239 1.335 0.334
ENSG00000112659 E047 23.1236923 0.0010569687 1.902885e-01 3.141439e-01 6 43206354 43206380 27 + 1.301 1.402 0.351
ENSG00000112659 E048 37.7222908 0.0005484404 9.601417e-01 9.789089e-01 6 43206381 43206510 130 + 1.570 1.571 0.004
ENSG00000112659 E049 1.3921893 0.0146940696 3.259536e-02 7.699190e-02 6 43212769 43213148 380 + 0.564 0.192 -2.255
ENSG00000112659 E050 31.5426105 0.0006616044 6.981405e-01 7.981643e-01 6 43213149 43213294 146 + 1.476 1.504 0.098
ENSG00000112659 E051 13.4870359 0.0013198681 5.532408e-01 6.824221e-01 6 43213438 43213483 46 + 1.107 1.166 0.212
ENSG00000112659 E052 13.0181928 0.0014174522 1.675133e-01 2.849604e-01 6 43213484 43213500 17 + 1.037 1.174 0.495
ENSG00000112659 E053 21.6978155 0.0010055905 9.249480e-02 1.790203e-01 6 43213501 43213567 67 + 1.249 1.383 0.467
ENSG00000112659 E054 1.6671050 0.0083087169 2.602939e-01 3.977792e-01 6 43213568 43213647 80 + 0.516 0.325 -1.033
ENSG00000112659 E055 2.5400402 0.0511050028 5.600177e-01 6.880814e-01 6 43213648 43213702 55 + 0.607 0.507 -0.457
ENSG00000112659 E056 2.8356816 0.0058059372 9.417106e-01 9.673501e-01 6 43213703 43213712 10 + 0.564 0.578 0.066
ENSG00000112659 E057 24.7546980 0.0010814553 8.764227e-03 2.569336e-02 6 43213713 43213796 84 + 1.258 1.456 0.689
ENSG00000112659 E058 21.8689561 0.0101456458 4.673471e-02 1.033532e-01 6 43213797 43213822 26 + 1.210 1.400 0.666
ENSG00000112659 E059 27.3784626 0.0036341907 1.152195e-01 2.131765e-01 6 43213823 43213912 90 + 1.355 1.477 0.421
ENSG00000112659 E060 40.3414034 0.0006662531 1.810685e-01 3.025587e-01 6 43215079 43215326 248 + 1.551 1.631 0.272
ENSG00000112659 E061 35.7539646 0.0051654677 7.401902e-01 8.296735e-01 6 43216158 43216385 228 + 1.532 1.559 0.090
ENSG00000112659 E062 25.6023150 0.0009383765 1.841828e-01 3.064811e-01 6 43216386 43216503 118 + 1.341 1.439 0.341
ENSG00000112659 E063 27.6716113 0.0105892587 6.506700e-02 1.351432e-01 6 43220459 43220565 107 + 1.333 1.497 0.566
ENSG00000112659 E064 18.5634642 0.0460948051 5.292125e-01 6.620293e-01 6 43220566 43220599 34 + 1.221 1.313 0.324
ENSG00000112659 E065 34.4019361 0.0224202099 9.883873e-02 1.887038e-01 6 43220747 43220911 165 + 1.410 1.588 0.610
ENSG00000112659 E066 4.1286643 0.0039567545 1.980002e-01 3.237157e-01 6 43220912 43221157 246 + 0.564 0.759 0.832
ENSG00000112659 E067 43.9600971 0.0103230645 2.581219e-03 9.008095e-03 6 43221158 43221321 164 + 1.470 1.707 0.808
ENSG00000112659 E068 8.1657468 0.0168432916 7.753597e-01 8.552864e-01 6 43221505 43221684 180 + 0.972 0.943 -0.106
ENSG00000112659 E069 32.4990928 0.0022412322 4.987935e-03 1.589539e-02 6 43221685 43221756 72 + 1.377 1.571 0.668
ENSG00000112659 E070 18.5722117 0.0347301888 8.340609e-03 2.464329e-02 6 43221757 43221778 22 + 1.037 1.380 1.216
ENSG00000112659 E071 4.0544656 0.0040594697 1.243543e-02 3.458391e-02 6 43221779 43222315 537 + 0.402 0.799 1.800
ENSG00000112659 E072 30.6242779 0.0167648974 1.384069e-04 6.965645e-04 6 43222316 43222390 75 + 1.220 1.591 1.284
ENSG00000112659 E073 0.2214452 0.0367674682 6.475596e-01   6 43222391 43222530 140 + 0.000 0.107 7.974
ENSG00000112659 E074 35.6808340 0.0120360903 1.654087e-04 8.154095e-04 6 43222531 43222641 111 + 1.325 1.647 1.106
ENSG00000112659 E075 1.2136029 0.0109928570 4.652780e-01 6.049961e-01 6 43222642 43222778 137 + 0.246 0.379 0.874
ENSG00000112659 E076 39.5903426 0.0013880281 1.945741e-05 1.210557e-04 6 43222779 43222896 118 + 1.404 1.672 0.919
ENSG00000112659 E077 13.4453336 0.0037283699 8.872537e-01 9.319558e-01 6 43222897 43223239 343 + 1.132 1.149 0.063
ENSG00000112659 E078 4.0492844 0.0040490481 6.535089e-01 7.639520e-01 6 43223240 43223263 24 + 0.646 0.714 0.289
ENSG00000112659 E079 44.0236939 0.0005175360 1.479975e-08 1.767712e-07 6 43223264 43223397 134 + 1.397 1.732 1.145
ENSG00000112659 E080 3.2461918 0.0052115914 3.558725e-01 5.002298e-01 6 43223398 43224094 697 + 0.516 0.665 0.667
ENSG00000112659 E081 40.6297160 0.0005529469 9.411036e-08 9.603514e-07 6 43224095 43224168 74 + 1.370 1.697 1.121
ENSG00000112659 E082 62.8363938 0.0009520441 1.256025e-11 2.573269e-10 6 43224250 43224954 705 + 1.542 1.889 1.175