ENSG00000112655

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000230419 ENSG00000112655 HEK293_OSMI2_2hA HEK293_TMG_2hB PTK7 protein_coding protein_coding 48.70872 64.98151 32.08859 2.403794 0.8577443 -1.017742 14.486516 11.006833 21.1247498 5.3758790 0.47540978 0.9399075 0.35250000 0.16530000 0.659800000 0.494500000 5.615852e-02 2.823579e-12 FALSE TRUE
ENST00000349241 ENSG00000112655 HEK293_OSMI2_2hA HEK293_TMG_2hB PTK7 protein_coding protein_coding 48.70872 64.98151 32.08859 2.403794 0.8577443 -1.017742 4.402113 6.055767 2.3086759 0.6944679 0.07422322 -1.3873890 0.08336250 0.09376667 0.072166667 -0.021600000 4.804000e-01 2.823579e-12 FALSE TRUE
ENST00000461389 ENSG00000112655 HEK293_OSMI2_2hA HEK293_TMG_2hB PTK7 protein_coding nonsense_mediated_decay 48.70872 64.98151 32.08859 2.403794 0.8577443 -1.017742 2.548110 4.393091 0.5054722 1.4408334 0.50547221 -3.0945500 0.04524167 0.06870000 0.016433333 -0.052266667 1.426137e-01 2.823579e-12 FALSE TRUE
ENST00000473339 ENSG00000112655 HEK293_OSMI2_2hA HEK293_TMG_2hB PTK7 protein_coding protein_coding 48.70872 64.98151 32.08859 2.403794 0.8577443 -1.017742 3.324310 2.139890 1.3430514 0.6374017 0.47534206 -0.6680460 0.06880000 0.03233333 0.041366667 0.009033333 9.237440e-01 2.823579e-12 FALSE FALSE
ENST00000481273 ENSG00000112655 HEK293_OSMI2_2hA HEK293_TMG_2hB PTK7 protein_coding protein_coding 48.70872 64.98151 32.08859 2.403794 0.8577443 -1.017742 4.821631 7.893875 0.2429481 2.4611167 0.12150576 -4.9656468 0.09927917 0.12346667 0.007433333 -0.116033333 7.099753e-03 2.823579e-12 FALSE TRUE
ENST00000489707 ENSG00000112655 HEK293_OSMI2_2hA HEK293_TMG_2hB PTK7 protein_coding protein_coding 48.70872 64.98151 32.08859 2.403794 0.8577443 -1.017742 9.605245 20.790482 1.5578311 0.7361948 0.80537722 -3.7297749 0.16302083 0.32000000 0.047400000 -0.272600000 1.693790e-01 2.823579e-12 FALSE TRUE
ENST00000494146 ENSG00000112655 HEK293_OSMI2_2hA HEK293_TMG_2hB PTK7 protein_coding nonsense_mediated_decay 48.70872 64.98151 32.08859 2.403794 0.8577443 -1.017742 1.553449 4.522558 0.0000000 1.1428683 0.00000000 -8.8241816 0.02386667 0.06906667 0.000000000 -0.069066667 2.823579e-12 2.823579e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112655 E001 2.659243 0.0427553751 1.944702e-07 1.867677e-06 6 43076307 43076313 7 + 0.911 0.000 -13.567
ENSG00000112655 E002 8.226467 0.0110012038 1.259363e-14 4.084620e-13 6 43076314 43076332 19 + 1.319 0.316 -4.211
ENSG00000112655 E003 11.072849 0.0016744580 3.204348e-17 1.464899e-15 6 43076333 43076338 6 + 1.415 0.532 -3.378
ENSG00000112655 E004 11.294294 0.0017779855 1.612133e-16 6.764423e-15 6 43076339 43076341 3 + 1.415 0.565 -3.226
ENSG00000112655 E005 19.938724 0.0009314247 3.790640e-27 4.956007e-25 6 43076342 43076368 27 + 1.654 0.783 -3.118
ENSG00000112655 E006 75.815791 0.0138725032 2.564542e-07 2.406244e-06 6 43076369 43076567 199 + 2.046 1.715 -1.117
ENSG00000112655 E007 1.718975 0.0538561132 2.358632e-01 3.693926e-01 6 43076814 43076986 173 + 0.254 0.497 1.430
ENSG00000112655 E008 212.152439 0.0044098871 4.576861e-07 4.078806e-06 6 43128977 43129264 288 + 2.412 2.238 -0.582
ENSG00000112655 E009 18.242155 0.0010470085 1.360178e-01 2.425011e-01 6 43129265 43129617 353 + 1.161 1.312 0.531
ENSG00000112655 E010 161.303711 0.0003384501 2.896239e-20 1.907802e-18 6 43129727 43129829 103 + 2.327 2.088 -0.799
ENSG00000112655 E011 226.103913 0.0008415708 1.924833e-23 1.793674e-21 6 43130230 43130420 191 + 2.473 2.230 -0.810
ENSG00000112655 E012 136.386111 0.0048529212 2.596421e-06 1.971163e-05 6 43130511 43130590 80 + 2.222 2.040 -0.611
ENSG00000112655 E013 135.832214 0.0002689548 2.524921e-13 6.782061e-12 6 43130591 43130661 71 + 2.230 2.030 -0.672
ENSG00000112655 E014 1.067502 0.0118740866 1.128837e-02 3.184884e-02 6 43131714 43132015 302 + 0.529 0.103 -3.156
ENSG00000112655 E015 214.404125 0.0013419139 9.254134e-11 1.642620e-09 6 43132016 43132164 149 + 2.410 2.244 -0.553
ENSG00000112655 E016 199.587581 0.0036314181 6.326470e-05 3.474002e-04 6 43132421 43132525 105 + 2.355 2.231 -0.413
ENSG00000112655 E017 239.071881 0.0034205216 1.008337e-06 8.356730e-06 6 43132526 43132687 162 + 2.446 2.299 -0.489
ENSG00000112655 E018 8.221772 0.0035641277 5.367482e-01 6.684592e-01 6 43132688 43132765 78 + 0.988 0.941 -0.175
ENSG00000112655 E019 26.054539 0.0007839876 8.638758e-01 9.162394e-01 6 43132766 43133721 956 + 1.408 1.421 0.044
ENSG00000112655 E020 3.116904 0.1104654909 1.040966e-01 1.967454e-01 6 43138553 43138848 296 + 0.761 0.461 -1.337
ENSG00000112655 E021 206.529561 0.0021289354 2.114047e-10 3.524907e-09 6 43138849 43138982 134 + 2.402 2.220 -0.605
ENSG00000112655 E022 86.211026 0.0003247397 3.919956e-08 4.318836e-07 6 43139136 43139150 15 + 2.027 1.841 -0.626
ENSG00000112655 E023 167.385637 0.0002273704 2.281741e-15 8.230559e-14 6 43139151 43139271 121 + 2.321 2.126 -0.650
ENSG00000112655 E024 173.731562 0.0010690278 2.763508e-09 3.778696e-08 6 43139406 43139525 120 + 2.317 2.161 -0.523
ENSG00000112655 E025 293.217728 0.0002386918 5.118679e-01 6.468064e-01 6 43141668 43141817 150 + 2.440 2.451 0.037
ENSG00000112655 E026 298.454620 0.0038280074 3.369318e-02 7.914339e-02 6 43141931 43142041 111 + 2.385 2.490 0.352
ENSG00000112655 E027 180.746228 0.0050758584 1.164097e-01 2.148351e-01 6 43142042 43142081 40 + 2.175 2.271 0.322
ENSG00000112655 E028 129.757800 0.0042398871 7.815745e-03 2.331763e-02 6 43142172 43142187 16 + 1.994 2.143 0.498
ENSG00000112655 E029 279.123439 0.0023076201 1.802808e-01 3.015269e-01 6 43142188 43142299 112 + 2.379 2.449 0.234
ENSG00000112655 E030 8.712184 0.0257307094 4.219050e-02 9.507505e-02 6 43142300 43142347 48 + 1.097 0.858 -0.890
ENSG00000112655 E031 9.052590 0.0278493637 9.631525e-02 1.848509e-01 6 43142348 43142376 29 + 1.098 0.901 -0.725
ENSG00000112655 E032 7.675855 0.0329255864 2.499805e-01 3.858901e-01 6 43142377 43142378 2 + 1.006 0.869 -0.513
ENSG00000112655 E033 11.921599 0.0281924122 1.899811e-02 4.932958e-02 6 43142379 43142498 120 + 1.247 0.989 -0.932
ENSG00000112655 E034 5.962745 0.0132574587 1.218118e-02 3.396455e-02 6 43142499 43142502 4 + 1.005 0.699 -1.191
ENSG00000112655 E035 61.741766 0.0031402231 1.235986e-04 6.303437e-04 6 43142503 43143384 882 + 1.878 1.704 -0.588
ENSG00000112655 E036 15.708519 0.0012578905 5.205508e-01 6.545087e-01 6 43143385 43143416 32 + 1.227 1.195 -0.112
ENSG00000112655 E037 432.821891 0.0001706191 9.333353e-02 1.803304e-01 6 43143417 43143620 204 + 2.578 2.635 0.188
ENSG00000112655 E038 1.587508 0.0098372289 9.374521e-01 9.646585e-01 6 43144299 43144299 1 + 0.413 0.415 0.011
ENSG00000112655 E039 6.572825 0.0024774358 9.640089e-01 9.813043e-01 6 43144300 43144450 151 + 0.842 0.870 0.107
ENSG00000112655 E040 413.402875 0.0014598868 3.496891e-03 1.171548e-02 6 43144451 43144606 156 + 2.528 2.630 0.342
ENSG00000112655 E041 3.960999 0.0082290922 1.136060e-03 4.424726e-03 6 43144607 43145199 593 + 0.911 0.458 -1.934
ENSG00000112655 E042 212.543020 0.0070754467 1.952811e-02 5.047400e-02 6 43145200 43145219 20 + 2.215 2.355 0.467
ENSG00000112655 E043 496.261318 0.0020789711 1.389462e-04 6.989629e-04 6 43145220 43145432 213 + 2.588 2.719 0.435
ENSG00000112655 E044 6.593450 0.0121942484 9.567881e-01 9.769093e-01 6 43145433 43146164 732 + 0.842 0.870 0.109
ENSG00000112655 E045 309.343947 0.0033657769 8.483590e-04 3.432041e-03 6 43146618 43146698 81 + 2.374 2.518 0.480
ENSG00000112655 E046 375.144609 0.0003800115 1.893049e-12 4.433583e-11 6 43158817 43158968 152 + 2.434 2.610 0.587
ENSG00000112655 E047 495.254299 0.0001358932 2.022830e-26 2.488436e-24 6 43159788 43159966 179 + 2.526 2.739 0.711
ENSG00000112655 E048 1464.596875 0.0022370427 1.604879e-16 6.739958e-15 6 43160721 43161719 999 + 3.003 3.211 0.692