ENSG00000112640

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000461010 ENSG00000112640 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5D protein_coding protein_coding 78.34252 121.7871 49.45236 1.722672 0.4137641 -1.300077 23.23012 44.30840 7.751124 3.560795 0.5466517 -2.513568 0.2668833 0.3645667 0.1568000 -0.207766667 3.926582e-06 2.115422e-37 FALSE TRUE
ENST00000470467 ENSG00000112640 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5D protein_coding protein_coding 78.34252 121.7871 49.45236 1.722672 0.4137641 -1.300077 9.57648 19.08773 7.346840 2.261700 0.6428503 -1.376243 0.1198625 0.1563333 0.1484667 -0.007866667 9.334463e-01 2.115422e-37 FALSE TRUE
ENST00000485511 ENSG00000112640 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5D protein_coding protein_coding 78.34252 121.7871 49.45236 1.722672 0.4137641 -1.300077 39.04974 51.26304 28.638098 3.896557 0.8232366 -0.839761 0.5231583 0.4206000 0.5793000 0.158700000 6.059191e-03 2.115422e-37 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112640 E001 1.822686 2.094711e-01 9.705222e-02 1.859714e-01 6 42984394 42984552 159 + 0.658 0.304 -1.806
ENSG00000112640 E002 2.961148 5.780621e-03 5.222945e-02 1.131277e-01 6 42984553 42984553 1 + 0.744 0.461 -1.265
ENSG00000112640 E003 8.824826 2.788403e-03 5.117179e-03 1.624877e-02 6 42984554 42984569 16 + 1.134 0.850 -1.052
ENSG00000112640 E004 30.869044 2.840181e-03 1.489149e-06 1.191816e-05 6 42984570 42984599 30 + 1.642 1.343 -1.028
ENSG00000112640 E005 94.125732 2.499534e-03 1.364459e-04 6.877913e-04 6 42984600 42984651 52 + 2.019 1.875 -0.484
ENSG00000112640 E006 116.437515 1.893297e-03 1.128035e-03 4.398084e-03 6 42984652 42984704 53 + 2.083 1.979 -0.348
ENSG00000112640 E007 136.623476 6.730993e-04 1.830761e-03 6.697542e-03 6 42989611 42989688 78 + 2.134 2.055 -0.266
ENSG00000112640 E008 1.472726 1.077707e-02 8.480814e-01 9.056990e-01 6 43006446 43006462 17 + 0.303 0.354 0.323
ENSG00000112640 E009 95.853982 4.087819e-03 6.365085e-01 7.505163e-01 6 43006463 43006486 24 + 1.920 1.926 0.018
ENSG00000112640 E010 277.689720 5.678124e-04 9.533399e-02 1.833875e-01 6 43006487 43006599 113 + 2.394 2.380 -0.046
ENSG00000112640 E011 173.298077 2.783963e-04 3.765124e-02 8.667705e-02 6 43006600 43006606 7 + 2.207 2.173 -0.112
ENSG00000112640 E012 319.135797 1.080507e-03 6.839605e-03 2.080946e-02 6 43006607 43006679 73 + 2.477 2.435 -0.140
ENSG00000112640 E013 284.248734 2.805023e-03 3.364047e-02 7.904201e-02 6 43006911 43006929 19 + 2.427 2.385 -0.140
ENSG00000112640 E014 242.989966 5.996203e-03 2.646215e-02 6.487278e-02 6 43006930 43006933 4 + 2.378 2.311 -0.224
ENSG00000112640 E015 421.242421 1.802032e-03 8.653515e-05 4.588252e-04 6 43006934 43007011 78 + 2.623 2.546 -0.258
ENSG00000112640 E016 515.431409 1.594032e-03 4.156683e-05 2.386421e-04 6 43007012 43007110 99 + 2.707 2.634 -0.244
ENSG00000112640 E017 641.197636 3.456360e-04 3.941958e-10 6.294606e-09 6 43007196 43007306 111 + 2.805 2.727 -0.259
ENSG00000112640 E018 609.575633 1.326866e-04 3.589293e-09 4.800091e-08 6 43007414 43007506 93 + 2.774 2.708 -0.219
ENSG00000112640 E019 803.698093 1.328350e-03 1.211734e-04 6.193760e-04 6 43007935 43008065 131 + 2.884 2.831 -0.176
ENSG00000112640 E020 14.465267 4.141179e-02 3.383145e-03 1.138818e-02 6 43008066 43008200 135 + 1.356 1.008 -1.238
ENSG00000112640 E021 633.308129 3.443738e-03 2.242000e-02 5.654985e-02 6 43008201 43008260 60 + 2.772 2.731 -0.137
ENSG00000112640 E022 1.191746 4.794446e-01 4.829229e-01 6.210250e-01 6 43008279 43008366 88 + 0.402 0.295 -0.647
ENSG00000112640 E023 744.769777 9.547168e-04 2.106162e-03 7.553070e-03 6 43008367 43008475 109 + 2.836 2.804 -0.106
ENSG00000112640 E024 7.670716 3.544705e-02 1.659009e-01 2.828601e-01 6 43008476 43008692 217 + 1.003 0.827 -0.669
ENSG00000112640 E025 514.636677 1.891886e-04 9.125998e-02 1.771023e-01 6 43008693 43008746 54 + 2.653 2.652 -0.004
ENSG00000112640 E026 7.198682 2.564926e-03 1.122550e-02 3.170630e-02 6 43008747 43009056 310 + 1.045 0.766 -1.063
ENSG00000112640 E027 548.392714 1.207161e-04 4.528576e-02 1.007171e-01 6 43009057 43009112 56 + 2.684 2.680 -0.015
ENSG00000112640 E028 680.725897 1.028409e-04 7.617538e-01 8.455445e-01 6 43009113 43009227 115 + 2.749 2.784 0.116
ENSG00000112640 E029 796.887892 9.645691e-05 1.013247e-01 1.924880e-01 6 43009322 43009449 128 + 2.803 2.856 0.179
ENSG00000112640 E030 764.775178 1.924118e-04 1.085652e-05 7.154356e-05 6 43010468 43010569 102 + 2.749 2.849 0.332
ENSG00000112640 E031 12.946813 1.091235e-02 8.911377e-01 9.344656e-01 6 43010634 43010663 30 + 1.083 1.097 0.052
ENSG00000112640 E032 649.162683 7.706242e-04 1.706758e-02 4.508745e-02 6 43010664 43010736 73 + 2.694 2.773 0.262
ENSG00000112640 E033 725.906725 7.049813e-04 3.950006e-03 1.300267e-02 6 43010881 43010997 117 + 2.737 2.823 0.287
ENSG00000112640 E034 3016.070853 3.386248e-03 1.897636e-12 4.443775e-11 6 43011149 43012342 1194 + 3.260 3.465 0.679